A5079369031- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Organic and Molecular Conductors Research
- Synthesis and Biological Evaluation
- Sulfur-Based Synthesis Techniques
University of Minnesota
2021-2024
Université de Strasbourg
2020
Protein prenylation typically involves linkage of the lipid via a thioether bond. Here we report discovery prenoylation, thioester-linked modification. In case ALDH9A1, this modification may serve an important regulatory function.
Two novel hetero- and homoleptic Au(<sc>iii</sc>) dithiolene complexes have been designed, synthesized, characterized employed for the elaboration of heterometallic coordination networks.
Abstract Protein prenylation is one example of a broad class post-translational modifications where proteins are covalently linked to various hydrophobic moieties. To globally identify and monitor levels all prenylated in cell simultaneously, our laboratory others have developed chemical proteomic approaches that rely on the metabolic incorporation isoprenoid analogues bearing bio-orthogonal functionality followed by enrichment subsequent quantitative analysis. Here, several improvements...