A5006823302- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Vitamin D Research Studies
- Crystallization and Solubility Studies
- Lignin and Wood Chemistry
- Microfluidic and Capillary Electrophoresis Applications
- X-ray Diffraction in Crystallography
- Pesticide Residue Analysis and Safety
- Fermentation and Sensory Analysis
- Marine and coastal ecosystems
- Pharmacological Effects and Toxicity Studies
- Isotope Analysis in Ecology
- Marine Toxins and Detection Methods
- Advanced Chemical Sensor Technologies
- Vitamin C and Antioxidants Research
- Ion-surface interactions and analysis
- Plant Gene Expression Analysis
- Biochemical and biochemical processes
- Analytical Chemistry and Sensors
- Biosensors and Analytical Detection
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquatic Ecosystems and Phytoplankton Dynamics
- Advanced Proteomics Techniques and Applications
Humboldt-Universität zu Berlin
2018-2025
Saarland University
2010-2019
National Center for Toxicological Research
1995-2014
Medical Research Council
2007-2010
MRC Human Nutrition Research
2007-2010
Sunnybrook Health Science Centre
2010
Society of Critical Care Medicine
2009
Université du Québec à Montréal
2009
Queen Elizabeth II Health Sciences Centre
2009
Radboud University Nijmegen
2008
Abstract Exploring the source, transformation pathways, and fate of natural organic matter (NOM) is critical to understanding regional/global carbon cycle budget. The dissolved fraction NOM, i.e., (DOM), a complex mixture resulting from plant, animal microbial plays crucial role in many biogeochemical processes at land-ocean-atmosphere interfaces. advance Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) makes detailed characterization DOM molecular level possible. On...
Vitamin D is an important determinant of bone health at all ages. The plasma concentrations 25-hydroxy vitamin (25-OH D) and other metabolites are used as biomarkers for sufficiency function. To allow the simultaneous determination five metabolites, 25-OH D(3), D(2), 24,25-(OH)(2) 1,25-(OH)(2) in low volumes human plasma, assay using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was established. Plasma samples were spiked with isotope-labeled internal...
Lignin is a component of lignocellulosic biomass and promising matrix for recovering important renewable aromatic compounds. We present new approach electro-oxidative cleavage lignin, dissolved in special protic ionic liquid, using an anode with particular electro-catalytic activity. As appropriate liquid triethylammonium methanesulfonate was identified, synthesised, explored dissolution alkali-lignin used electrolysis 5 wt.% lignin solutions. material, oxidation-stable...
Lignin's aromatic building blocks provide a chemical resource that is, in theory, ideal for substitution of petrochemicals. Moreover, degradation and valorization lignin has the potential to generate many high-value chemicals technical applications. In this study, electrochemical alkali Organosolv was performed using ionic liquids 1-ethyl-3-methylimidazolium trifluoromethanesulfonate triethylammonium methanesulfonate. The extensive investigated lignins with simultaneous almost full recovery...
'Wrong-way-round' electrospray ionization, in the present context, refers to observation of intense [M + H]+ ions electrosprayed from strongly basic solutions and − H]− acidic solutions. Most previous investigations this phenomenon have been directed at variations charge-state distributions for polyfunctional peptides proteins as a function bulk solution pH. The work extends that Hiraoka et al. (J. Mass Spectrom. Soc. Japan 43, 127 (1995)) on pH dependence absolute mass spectral intensities...
Simultaneous detection and confirmation of 15 quinolone antibiotics was accomplished by fast short-column liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/MS/MS). Several physiochemical parameters such as hydrophobicity aqueous dissociation constants were calculated from the structural formulas drugs, their impact on both chromatographic spectrometric behavior studied. Additionally, a possible influence bulk solution pH sensitivity 4-quinolones...
<i>Boswellia serrata</i> resin dry extract is among the few herbal remedies designated with an orphan drug status for treatment of peritumoral brain edema. In addition, boswellic acids (BAs), main active ingredients <i>B. extracts, have potent anti-inflammatory properties, and may represent promising agents inflammatory diseases. Pharmacokinetic studies, however, revealed poor bioavailability, especially 11-keto-β-boswellic acid (KBA) 3-acetyl-11-keto-β-boswellic (AKBA), most BAs. To address...
Post-translational modification of small GTPases by farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential contribution cancer, cardiovascular neurodegenerative diseases. Prenylated proteins have been identified in numerous cell functions elevated levels FPP GGPP previously proposed occur Alzheimer disease (AD) but never quantified. In the present study, we determined if mevalonate derived compounds are increased brain grey white matter...
In the present work we describe development of an analytical technique for simultaneous profiling over 100 biochemically related lipid mediators in biological samples. A multistep procedure was implemented to extract eicosanoids and other bioactive lipids from matrix, chromatographically separate them using fast reversed-phase liquid chromatography, tentatively identify new candidate through a matching process retention times, isotope distribution patterns, high-resolution orbitrap MS/MS...
Analytical applications often require rapid measurement of compounds from complex sample mixtures. High-speed mass spectrometry approaches frequently utilize techniques based on direct ionization the by laser irradiation, mostly means matrix-assisted desorption/ionization (MALDI). Compounds low molecular weight are difficult to analyze MALDI, however, because severe interferences in m/z range organic matrix used for desorption/ionization. In recent years, surface-assisted (SALDI) have shown...
Direct in-droplet (in stillo) microreaction monitoring using acoustically levitated micro droplets has been achieved by combining acoustic (ultrasonic) levitation for the first time with real ambient tandem mass spectrometry (MS/MS). The and inherent mixing of microliter volumes reactants (3 μL droplets), yielding total reaction 6 μL, supported acid-catalyzed degradation erythromycin A. This was chosen to demonstrate proof-of-principle directly in stillo microreactions via hyphenated...