A5060696796- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Catalytic Alkyne Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Click Chemistry and Applications
- Chemical Synthesis and Reactions
- Organophosphorus compounds synthesis
- Cyclopropane Reaction Mechanisms
University of the Basque Country
2021-2023
A previously unprecedented azo-Povarov reaction between N-carbonyl aryldiazenes and trans-cyclooctene derivatives has been developed. The participation of these in the uncatalyzed [4 + 2] cycloaddition enabled the...
We disclose the first accomplishment of azo-Povarov reaction involving Sc(OTf)3-catalyzed [4 + 2] annulations N-carbonyl aryldiazenes with cyclopentadiene in chloroform, which act as 4π-electron donors. Hence, this protocol offers a rapid access to an array cinnoline derivatives moderate good yields for substrates over wide scope. The synthetic potential was achieved by gram-scale and further derivatization obtained polycyclic product.
The use of MW allows the efficient palladium(II)-catalysed C-3 acylation thiophenes with aldehydes via C(sp2)-H activation for synthesis (cyclo)alkyl/aryl thienyl ketones (43 examples). Compared to standard thermal conditions, reduces reaction time (15 30 min vs. 1 3 hours), leading improved yields (up 92%). control positional selectivity is achieved by 2-pyridinyl and 2-pyrimidyl ortho-directing groups at C-2 thiophene scaffold. To show synthetic applicability, selected were subjected...
Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik-Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution of ethyl (2-bromomethyl)acrylate mild conditions afforded an original synthetic approach to new series bis(allylic-α-aminophosphonates).