A5005301806- Microbial Metabolic Engineering and Bioproduction
- Gene Regulatory Network Analysis
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Photoreceptor and optogenetics research
- Evolution and Genetic Dynamics
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Enzyme Catalysis and Immobilization
- Bacterial Genetics and Biotechnology
- Nonlinear Dynamics and Pattern Formation
- Plant Parasitism and Resistance
- Computational Drug Discovery Methods
- Mathematical and Theoretical Epidemiology and Ecology Models
- Acute Myocardial Infarction Research
- Blood properties and coagulation
- Evolutionary Game Theory and Cooperation
- Hemoglobin structure and function
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
- Antifungal resistance and susceptibility
- Fungal and yeast genetics research
- Bacterial biofilms and quorum sensing
Friedrich Schiller University Jena
2015-2025
Medical University of Vienna
2023
Silicon Austria Labs (Austria)
2022
Infineon Technologies (Austria)
2022
Voestalpine (Austria)
2022
Schiller International University
2012-2021
Max Planck Institute for Chemical Ecology
2019
Ernst Abbe University of Applied Sciences Jena
2004-2016
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2013
Johannes Kepler University of Linz
2006-2013
Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production. This may result in an evolutionary dilemma, because cells with higher but lower ATP production gain selective advantage when competing for shared energy resources. Using analysis model simulations biochemical observations, we show that low high can be viewed as form cooperative resource use evolve spatially structured environments. Furthermore, argue the respiration have...
Comparative analysis of metabolic pathways in different genomes yields important information on their evolution, pharmacological targets and biotechnological applications. In this study glycolysis, three alternative ways comparing biochemical are combined: (1) comparison data, (2) pathway based the concept elementary modes, (3) a comparative genome 17 completely sequenced genomes. The reveals surprising plasticity glycolytic pathway. Isoenzymes species identified compared; deviations from...
Alternative splicing (AS) is a cellular process that increases cell's coding capacity from limited set of genes.Although AS common in higher plants and animals, its prevalence other eukaryotes mostly unknown.In fungi the involvement gene expression effect on multi-cellularity virulence great medical economic interest.We present genome-wide comparative study 23 informative different taxa, based alignments public transcript sequences.Random sampling expressed sequence tags allows for robust...
Abstract Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors mortality in the old. Nevertheless, it has remained unclear what extent molecular signatures of reflect this phenomenon. Here we report on identification conserved transcriptomic signature based gene expression data four vertebrate species across tissues. We find that ageing-associated changes follow trajectories similar transcriptional alterations observed...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 124:227-236 (1995) - doi:10.3354/meps124227 Formation and significance of transparent exopolymeric particles in northern Adriatic Sea Schuster S, Herndl GJ We examined abundance bacterial colonization pattern (TEP) during 2 different ecological conditions along a trophic gradient Sea. Generally, neither TEP...
The “successional stage” of marine aggregates from formation to final decay was investigated in the northern Adriatic Sea summer 1991. In snow, bacterial biomass and production rates increased exponentially gellike (GEA — considered as late‐stage snow) reached values 2–3 orders magnitude higher than ambient water. Specific growth snow‐associated bacteria (0.31–1.76 d −1 ) were similar water bacteria; however, they significantly lower GEA (0.08–0.31 ). Concentrations dissolved free amino...
We study the structural robustness of metabolic networks on basis concept elementary flux modes. It is shown that number modes itself not an appropriate measure robustness. Instead, we introduce three new measures. These are based relative remaining after knockout enzymes. discuss relevance these measures with help simple examples, as well larger, realistic networks. Thereby demonstrate quantitatively metabolism Escherichia coli, which must be able to adapt varying conditions, more robust...
Substrate competition can be found in many types of biological processes, ranging from gene expression to signal transduction and metabolic pathways. Although several experimental silico studies have shown the impact substrate on these it is still often neglected, especially modelling approaches. Using toy models that exemplify different pathway scenarios, we show influence dynamics steady state concentrations a pathway. We additionally derived rate laws for reversible reactions summarise...
Alternative splicing (AS) is an important regulatory mechanism in eukaryotes but only little known about its impact fungi. Human fungal pathogens are of high clinical interest causing recurrent or life-threatening infections. AS can be well-investigated genome-wide and quantitatively with the powerful technology RNA-Seq. Here, we systematically studied human based on RNA-Seq data. To do so, investigated effect seven fungi during conditions simulating ex vivo infection processes vitro stress....