A5005231542- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Malaria Research and Control
- Metabolism and Genetic Disorders
- Carbohydrate Chemistry and Synthesis
- Birth, Development, and Health
- Multiple Myeloma Research and Treatments
- Neonatal Health and Biochemistry
- Material Properties and Processing
- Digestive system and related health
- Venomous Animal Envenomation and Studies
- Renal function and acid-base balance
- Drug Transport and Resistance Mechanisms
- Calcium signaling and nucleotide metabolism
- Growth Hormone and Insulin-like Growth Factors
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Cellular transport and secretion
- Invertebrate Immune Response Mechanisms
- Image and Object Detection Techniques
- Toxoplasma gondii Research Studies
- Gestational Diabetes Research and Management
- Research on Leishmaniasis Studies
- Industrial Vision Systems and Defect Detection
- Congenital Heart Disease Studies
Sir Ganga Ram Hospital
2015-2025
Center for Rheumatology
2024
Indian Institute of Technology Goa
2017
National Institute of Immunology
2007-2012
The role of protein phosphorylation in the life cycle malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to assess importance Plasmodium falciparum asexual proliferation. We identify 1177 sites on 650 parasite proteins that are involved a wide range general cellular activities such as DNA synthesis, transcription and metabolism well key processes invasion cyto-adherence. Several kinases themselves phosphorylated putative...
Molecular mechanisms by which signaling pathways operate in the malaria parasite and control its development are promiscuous. Recently, we reported identification of a pathway Plasmodium falciparum, involves activation protein kinase B-like enzyme (PfPKB) calcium/calmodulin (Vaid, A., Sharma, P. (2006) J. Biol. Chem. 281, 27126-27133). Studies carried out to elucidate function this suggested that it may be important for erythrocyte invasion. Blocking upstream activators pathway, calmodulin...
To offer accurate prenatal diagnosis of lysosomal storage disorders in early pregnancy.Prenatal enzymatic diagnoses Gaucher, Fabry, Pompe, Niemann Pick A/B, Tay Sach, Sandoff, GM1, mucoplysaccharidoses, Wolman, Krabbe, Metachromatic leukodystrophy and Batten diseases were made uncultured chorionic villi samples by fluorometric/spectrophotometric methods.Of 331 diagnosis, 207 fetuses (67%) normal 124 (37%) affected. The interpretation affected, carrier was done using their respective...
High consanguinity rates, poor access to accurate diagnostic tests, and costly therapies are the main causes of increased burden lysosomal storage disorders (LSDs) in developing countries. Therefore, there is a major unmet need for economical tests facilitate diagnosis consideration before irreversible complications occur. In cross-country study, we utilized dried blood spots (DBS) 1,033 patients clinically suspected harbor LSDs enzymatic using modified fluorometric assays from March 2013...
Abstract Background: In India, the tradition of marriages, largely confined to same ethnic groups or within families, increases proportion autosomal recessive genetic disorders. This includes organic acidemias (OAs) too. With immense burden treatment these disorders, uptake prenatal diagnosis (PND) is high. We present our experience in PND for common five OAs, namely methylmalonic acidemia (MMA), propionic (PA), glutaric type 1 (GA1), isovaleric (IVA), and maple syrup urine disease (MSUD)....
The actomyosin motor complex of the glideosome provides force needed by apicomplexan parasites such as Toxoplasma gondii (Tg) and Plasmodium falciparum (Pf) to invade their host cells for gliding motility motile forms. Glideosome Associated Protein 45 (PfGAP45) is an essential component it facilitates anchoring effective functioning motor. Dissection events that regulate PfGAP45 may provide insights into how operate. We found phosphorylated in response Phospholipase C (PLC) calcium...
Abstract Newborn screening (NBS) aims toward early detection of treatable congenital disorders. From January 2008 through December 2017, 13,376 newborns were screened for hypothyroidism (CH), adrenal hyperplasia (CAH), and glucose-6-phosphate dehydrogenase (G6PD) deficiency at Sir Ganga Ram Hospital, India, by measuring G6PD activity, thyroid-stimulating hormone, 17-hydroxyprogesterone on dried blood specimens. The birth prevalence 1:2,000 CH, 1:2,500 CAH, 1:125 indicates the latter as most...
To determine the diagnostic accuracy of preeclampsia (PE) screening test offered in early pregnancy for prediction risks early-onset (requiring delivery <32 weeks gestation) and late-onset ≥32 disease.In a retrospective study 615 women with singleton pregnancy, risk PE was calculated by combined effect multiple variables: serum placental growth factor (PLGF) pregnancy-associated plasma protein-A (PAPP-A), maternal age, parity, ethnicity, mean arterial pressure (MAP), body mass index (BMI),...
To characterize gastrointestinal (GI) symptoms in patients with a diagnosis of new-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES).
This paper reviews on a Bare Printed Circuit Board inspection system using image analysis wherein the algorithm mainly focuses defect detection and classification real images.In this project, we have built MATLAB program to detect PCB faults classify them results are properly shown GUI MATLAB.This reduces flaws in JIG tool by human visual inspection.MATLAB processing software combined with Arduino hardware provides low cost solution for inspection.