A prospective, dose-escalating, quasi-experimental clinical trial was conducted with a traditional healer using decoction of Argemone mexicana for the treatment malaria in Mali. The remedy prescribed three regimens: once daily 3 days (Group A; n=23); twice 7 B; n=40); and four times first 4 followed by C; n=17). Thus, 80 patients were included, whom 80% aged<5 years 25% aged<1 year. All presented to symptoms had Plasmodium falciparum parasitaemia>2000/microl but no signs severe malaria....

A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In attempt reflect real situation in home-based management remote Malian village, 301 patients presumed uncomplicated (median age 5 years) were randomly assigned receive AM or artesunate-amodiaquine [artemisinin combination...

Recent WHO guidelines recommend a universal "test and treat" strategy for malaria, mainly by use of rapid diagnostic test (RDT) in all areas. The evidence this approach is questioned here as there risk over-reliance on parasitological diagnosis high transmission situations, which still exist. In such areas, when patient has fever or other malaria symptoms, the presence Plasmodium spp neither reliably confirms cause fever, nor excludes possibility diseases. This because may be an asymptomatic...

Use of official health services often remains low despite great efforts to improve quality care. Are informal treatments responsible for keeping a number patients away from standard care, and if so, why? Through questionnaire survey with proportional cluster samples, we studied the case histories 952 children in Bandiagara Sikasso areas Mali. Most reported uncomplicated malaria were first treated at home (87%) modern medicines alone (40%), mixture traditional (33%), or treatment (27%). For...

Classical pharmacology has been the basis for discovery of new chemical entities with therapeutic effects decades. In natural product research, compounds are generally tested in vivo only after full vitro characterization. However drug screening using this methodology is expensive, time-consuming and very often inefficient. Reverse pharmacology, also called bedside-to-bench, a research approach based on traditional knowledge relates to reversing classical laboratory clinic pathway practice....

Hypoglycaemia (glucose <2.2 mmol/l) is a defining feature of severe malaria, but the significance other levels blood glucose has not previously been studied in children with malaria.A prospective study 437 consecutive presumed malaria was conducted Mali. We defined hypoglycaemia as mmol/l, low glycaemia 2.2-4.4 mmol/l and hyperglycaemia >8.3 mmol/l. Associations between case fatality were analysed for 418 using logistic regression models receiver operator curve (ROC).There significant...

Abstract Background Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible rural areas. The efficacy of sublingual sugar (SLS) was assessed pilot randomized controlled trial among hypoglycaemic children with malaria Mali. Methods Of 151 patients presumed malaria, 23 blood glucose concentrations &lt; 60 mg/dl (&lt; 3.3 mmol/l) were assigned randomly to receive either intravenous 10% (IVG; n = 9) or (SLS; 14). In SLS, teaspoon sugar, moistened...

Rapid diagnostic tests (RDT) are sometimes recommended to improve the home-based management of malaria. The accuracy an RDT for detection clinical malaria and presence malarial parasites has recently been evaluated in a high-transmission area southern Mali. During same study, cost-effectiveness 'test-and-treat' strategy (based on artemisinin-combination therapy) was compared with that 'treat-all' strategy. Overall, 301 patients, all ages, each whom had considered presumptive case...

Argemone mexicana (AM), a validated herbal medicine for uncomplicated malaria, seems to prevent severe malaria without completely clearing parasites in most patients. This study, high transmission area of South Mali, explores whether residual parasitaemia at day 28 was associated with subsequent episodes and/or anaemia. Three hundred and one patients were randomly assigned AM or artesunate/amodiaquine as first line treatment, whom 294 followed up beyond the standard days, 84 days. From 29...

In 2003, a study in Mali showed that 87% of episodes uncomplicated malaria were first treated at home. We investigated whether treatment-seeking patterns had changed 10 years later. 2013, we repeated the retrospective treatment-outcome on 400 children with presumed same area. Most reported still home (76% [196/258] 2013 vs 85% 2003; p=0.006), rather than modern health centres (20% [52/258] 12% p=0.01). Overall, 58% herbal medicine alone, significant increase from 24% earlier (p<0.001). This...

Objectives: To assess the use of Hibiscus sabdariffa (HS), known as karkade in Jordan, cases uncontrolled hypertension, either with or without medication, validated by several clinical trials. Design: A multicentric pilot study. Location: Outside a refugee camp Jordan. Subjects: Thirty-eight participants blood pressure (BP) above 140/90 mmHg consumed H. tea. Intervention: Consumption tea containing 10 g HS/0.5 L daily. This dosage was increased to 15 HS/1 and 20 during second third weeks,...

In Ethiopia, medicinal plants have been used to treat different diseases, including malaria, for many centuries. People living in rural areas are especially noted their use of as a major component health care. This study aimed treatment-seeking and prioritize plants/plant recipes anti-malarials, Dembia district, one the malarious districts Northwest Ethiopia. Parents children aged under 5 years who had recent episode fever were interviewed retrospectively about child's treatment...