A5091190206- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hemophilia Treatment and Research
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- Immune responses and vaccinations
- CAR-T cell therapy research
- Viral Infections and Outbreaks Research
- Blood Coagulation and Thrombosis Mechanisms
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- interferon and immune responses
- Poxvirus research and outbreaks
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Long-Term Effects of COVID-19
Thomas Jefferson University
2023-2024
Children's Hospital of Philadelphia
2019-2023
The role of CD8
Genetically modified (GM) mice are essential tools in biomedical research. Traditional methods for generating GM expensive and require specialized personnel equipment. The use of clustered regularly interspaced short palindromic repeats (CRISPR) coupled with improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) has highly increased the feasibility producing research laboratories. However, genetic modification inbred mouse strains interest such as C57BL/6 (B6) is still...
The role of CD4
Receptor-interacting protein kinase 3 (RIPK3) and mixed lineage domain-like pseudokinase (MLKL) are proteins that critical for necroptosis, a mechanism of programmed cell death is both activated when apoptosis inhibited thought to be antiviral. Here, we investigated the role RIPK3 MLKL in controlling Orthopoxvirus ectromelia virus (ECTV), natural pathogen mouse. We found C57BL/6 (B6) mice deficient (Ripk3-/-) or (Mlkl-/-) were as susceptible wild-type (WT) B6 ECTV lethality after low-dose...