A5056569631- Neuroscience of respiration and sleep
- Pulmonary Hypertension Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Connexins and lens biology
Charité - Universitätsmedizin Berlin
2017-2021
Humboldt-Universität zu Berlin
2020-2021
Freie Universität Berlin
2020-2021
Czech Academy of Sciences, Institute of Physiology
2021
German Centre for Cardiovascular Research
2021
University of Toronto
2020
St. Michael's Hospital
2020
Abstract Aims Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated better aerated lung areas optimize ventilation-perfusion matching. Yet, the exact sensory and signalling mechanisms by which triggers remain incompletely understood. Recently, ATP release via pannexin 1 (Panx1) subsequent purinergic P2Y receptors has been identified as regulator of in systemic arterioles. Here, we probed for role Panx1-mediated...
Study objective Endothelial dysfunction and increased microvascular permeability are hallmarks of severe COVID-19. At present, the extent endothelial barrier failure its underlying mechanisms in COVID‑19 remain unclear. We hypothesized that leak results from bioactive mediators released COVID-19 rather than direct infection can thus be recapitulated ex vivo by treating cells with patient plasma, providing a personalized screening platform for barrier-protective interventions Methods Citrate...
Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia by which blood flow redirected from poorly ventilated areas better aerated lung regions. Sustained HPV plays critical role in the development of hypertension (PH) but exact signaling pathways underlying remain incompletely defined. Recently, ATP release via Pannexin 1 (Panx1) and subsequent purinergic have been linked transient receptor potential vanlloid 4 (TRPV4) channel mediated Ca2+ systemic...