A5020914791- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Peptidase Inhibition and Analysis
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Health Systems, Economic Evaluations, Quality of Life
City Of Hope National Medical Center
2017-2025
City of Hope
2016-2024
Beckman Research Institute
2017-2023
Weatherford College
2020
Université Grenoble Alpes
2018
Centre Hospitalier Universitaire de Grenoble
2018
University of Chicago
2014-2016
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that in isogenic cells correlated with increased expression of integrin β4 (ITGB4), component the focal adhesion complex. Silencing ITGB4 tolerant improved sensitivity, while overexpressing enhanced tolerance by supporting AKT-mTOR bypass signaling. Chronic treatment induced WNT and activated WNT/β-catenin signaling pathway. Thus, silencing both β-catenin significantly...
Lung cancer can be classified into two main categories: small cell lung (SCLC) and non-small (NSCLC), which are different in treatment strategy survival probability. The CT images of SCLC NSCLC similar such that their subtle differences hardly visually discernible by the human eye through conventional imaging evaluation. We hypothesize SCLC/NSCLC differentiation could achieved via a computerized feature analysis classification. purpose this study was to use radiomics differentiate from...
Background: Brain metastases are associated with poor survival. Molecular genetic testing informs on targeted therapy and The purpose of this study was to perform a MR imaging-based radiomic analysis brain from non-small cell lung cancer (NSCLC) identify features that were important for predicting survival duration. Methods: We retrospectively identified our cohort via an institutional database search patients EGFR, ALK, and/or KRAS mutation-positive NSCLC. segmented the metastatic tumors...
EGFR-mutated lung adenocarcinoma patients who received tyrosine kinase inhibitors (TKIs) may initially respond to therapy, but over time, resistance eventually occurs. In a small population (5-10%), these can have histological transformation SCLC. Nine with transformed SCLC were evaluated at City of Hope. Patient clinical and pathology data, including multiple next-generation sequencing (NGS) results, therapies, histology, outcomes, collected across time points. Descriptive statistics...
Lung cancer is a devastating disease with overall bleak prognosis. Current methods to diagnose lung are rather invasive and inadequate detect the at an early stage when treatment likely be most effective. In this study, shotgun sequencing approach was used study microRNA (miRNA) cargo of serum-derived exosomes small cell (SCLC) (n=9) non-small (NSCLC) (n=11) patients, healthy controls (n=10). The has identified 17 miRNA species that differentially expressed in patients control subjects....
Reversible changes in lung microstructure accompany inflammation, although alterations tissue micromechanics and their impact on inflammation remain unknown. This study investigated extracellular matrix (ECM) remodeling stiffness a model of LPS-induced examined the role lipoxin analog 15-epi-lipoxin A4 (eLXA4) reduction stiffness-dependent exacerbation inflammatory process. Atomic force microscopy measurements live slices were used to directly measure local induced by intratracheal injection...
KRAS mutations reported in non-small cell lung cancer (NSCLC) represent a significant percentage of patients diagnosed with NSCLC. However, there still remains no therapeutic option designed to target KRAS. In an era immunotherapy as dominant treatment metastatic NSCLC, the role in.mutated is not clear.Eligible NSCLC and found have mutation were identified institutional database. Demographic, clinical, molecular data was collected analyzed.A total 60 for this retrospective analysis. Majority...
Tumor heterogeneity and cisplatin resistance are major causes of tumor relapse poor survival. Here, we show that in lung cancer, interaction between paxillin (PXN) integrin β4 (ITGB4), components the focal adhesion (FA) complex, contributes to resistance. Knocking down PXN ITGB4 attenuated cell growth improved sensitivity, both 2D 3D cultures. independently regulated expression several genes. In addition, they also common genes including USP1 VDAC1, which required for maintaining genomic...
The usefulness of circulating tumor DNA (ctDNA) in detecting mutations and monitoring treatment response has not been well studied beyond a few actionable biomarkers non-small cell lung cancer (NSCLC).
Lung cancer is the leading cause of cancer-related death in both men and women with over 130,000 deaths more than 220,000 new cases expected each year United States 1 Siegel RL Miller KD Wagle NS Jemal A. Cancer statistics, 2023. CA J Clin. 2023; 73: 17-48 Crossref PubMed Scopus (695) Google Scholar . Eighty to ninety percent newly diagnosed are Non-Small Cell (NSCLC) 50% those being histologically adenocarcinoma 2 Servetto A Esposito D Ferrara R et al. RET rearrangements non-small cell lung...
Acute lung injury (ALI) is accompanied by decreased compliance. However, a role of tissue mechanics in modulation inflammation remains unclear. We hypothesized that bacterial lipopolysacharide (LPS) stimulates extracellular matrix (ECM) production and vascular stiffening leading to stiffness-dependent exacerbation endothelial cell (EC) inflammatory activation barrier dysfunction. Expression GEF-H1, ICAM-1, VCAM-1, ECM proteins fibronectin collagen, lysyl oxidase (LOX) activity, interleukin-8...
Oncogenic (mutant) Ras protein Kirsten rat sarcoma viral oncogene homolog (KRAS) promotes uncontrolled proliferation, altered metabolism, and loss of genome integrity in a cell-intrinsic manner. Here, we demonstrate that CD4+ T cells when incubated with tumor-derived exosomes from mutant (MT) KRAS non-small-cell lung cancer (NSCLC) cells, patient sera, or mouse xenograft model, induce phenotypic conversion to FOXP3+ Treg-like are immune-suppressive. Furthermore, transfecting MT cDNA alone...
Abstract Squamous cell carcinoma (SCC) and malignant pleural mesothelioma (MPM) are thoracic malignancies with very poor prognosis limited treatment options. It is an established fact that most of the solid tumors have overexpression EPHA2 receptor tyrosine kinase. known to exhibit opposing roles towards cancer progression. functions in inhibiting survival migration via a ligand kinase dependent signaling (Y772). Whereas it promote tumor progression through ligand-independent (S897). We...
Introduction Immune checkpoint inhibitors (ICIs) produce a broad spectrum of immune-related adverse events (irAEs) affecting various organ systems. While ICIs are established as therapeutic option in non-small cell lung cancer (NSCLC) treatment, most patients receiving ICI relapse. Additionally, the role on survival prior targeted tyrosine kinase inhibitor (TKI) therapy has not been well-defined. Objective To investigate impact irAEs, relative time occurrence, and TKI to predict clinical...
PURPOSE Leptomeningeal disease (LMD) is associated with significant morbidity and mortality for metastatic non–small cell lung cancer (NSCLC). We describe our clinical experience in evaluating the use of cerebrospinal fluid (CSF)–derived circulating tumor cells (CTCs) diagnosis LMD detection genomic alterations CSF cell-free DNA (cfDNA). METHODS Patients NSCLC who had collection as part routine care suspected were included study. was evaluated CTCs cfDNA using a commercial assay (CNSide;...
Tyrosine kinase inhibitors (TKIs) are now the standard of care first-line therapy for epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC) patients. Despite positive outcomes in most patients, with extended progression-free survival (PFS), a small population patients respond poorly to these drugs. Complex genetic and non-genetic resistance mechanisms may be drivers disease cancer, but further research is required identify clinic. Germline molecular...