A5016543239- Redox biology and oxidative stress
- Insect and Pesticide Research
- Mycotoxins in Agriculture and Food
- Photosynthetic Processes and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Metal-Catalyzed Oxygenation Mechanisms
- Polyamine Metabolism and Applications
- Enzyme Structure and Function
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Electron Spin Resonance Studies
Technical University of Denmark
2009-2013
Carlsberg Laboratory
2009-2013
Carlsberg Group (Denmark)
2013
Thioredoxins (Trxs) are protein disulfide reductases that regulate the intracellular redox environment and important for seed germination in plants. Trxs turn regulated by NADPH-dependent thioredoxin (NTRs), which provide reducing equivalents to Trx using NADPH recycle active form. Here, first crystal structure of a cereal NTR, HvNTR2 from Hordeum vulgare (barley), is presented, also monocot plant NTR. The was determined at 2.6 A resolution refined an R(cryst) 19.0% R(free) 23.8%. dimeric...
MINI REVIEW article Front. Plant Sci., 21 May 2013Sec. Physiology https://doi.org/10.3389/fpls.2013.00151
The ubiquitous disulfide reductase thioredoxin (Trx) regulates several important biological processes such as seed germination in plants. Oxidized cytosolic Trx is regenerated by nicotinamide adenine dinucleotide phosphate (NADPH)-dependent (NTR) a multistep transfer of reducing equivalents from NADPH to via tightly NTR-bound flavin. Here, interactions between NTR and are predicted molecular modelling the barley NTR:Trx complex (HvNTR2:HvTrxh2) probed site directed mutagenesis. Enzyme...