A5083904740- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Vitamin K Research Studies
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Blood disorders and treatments
- Allergic Rhinitis and Sensitization
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Autoimmune and Inflammatory Disorders Research
- Antifungal resistance and susceptibility
- Enzyme function and inhibition
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Rheumatoid Arthritis Research and Therapies
- Dermatological and COVID-19 studies
- Ocular Diseases and Behçet’s Syndrome
- Chemical Reactions and Mechanisms
Universidade de São Paulo
2016-2024
Clinics Hospital of Ribeirão Preto
2018-2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2019
Universidade Federal do Paraná
2018
Center for Rheumatology
2015
Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis. To investigate the efficacy of sublingual immunotherapy (SLIT) Dermatophagoides pteronyssinus extract dermatitis sensitized HDM. In this randomized, double-blind, placebo-controlled trial, we enrolled 91 3 years or older, SCORing Atopic Dermatitis (SCORAD) score greater than equal 15 and positive skin test result and/or IgE D pteronyssinus. Patients were stratified according age (<12 ≥12 years) receive...
To study the prevalence, risk factors, and mortality of invasive fungal infections (IFI) in patients with childhood-onset systemic lupus erythematosus (cSLE).A retrospective multicenter cohort was performed 852 cSLE from 10 pediatric rheumatology services. An investigator meeting held all participants received database training. IFI were diagnosed according to European Organization for Research Treatment Cancer/Invasive Fungal Infections Cooperative Group National Institute Allergy...
BackgroundMechanisms triggering the pathogenesis of chronic spontaneous urticaria (CSU) have been identified as type I autoallergic (which is associated with IgE antibodies against autoantigens) and IIb autoimmune driven by autoantibodies to FceR1 and/or IgE).ObjectiveOur aim was define presumptive endotypes in patients CSU using tests amenable use routine clinical practice.MethodsA retrospective analysis medical records 394 or without inducible angioedema performed. Patients were assigned 1...
Objective The aim of this multicenter study in a large childhood-onset systemic lupus erythematosus (cSLE) population was to assess the herpes zoster infection (HZI) prevalence, demographic data, clinical manifestations, laboratory findings, treatment, and outcome. Methods A retrospective cohort (Brazilian cSLE group) performed ten Pediatric Rheumatology services São Paulo State, Brazil, included 852 patients. HZI defined according presence acute vesicular-bullous lesions on...
<b><i>Background:</i></b> Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives this study were assess CSU large cSLE population, order evaluate demographic data, clinical manifestations, disease activity/damage, laboratory abnormalities treatment.<b><i> Methods:</i></b> A retrospective...
Background Whole-Genome Sequencing (WGS) and Whole-Transcriptome (WTS) have emerged as transformative tools in the diagnosis of rare diseases with complex phenotypes. These technologies enable deep analysis genome RNA expression, uncovering structural, intronic, non-coding, mitochondrial variants that traditional methods might miss, thus facilitating understanding gene function regulation. Methods We enrolled 8966 patients suspected or hereditary cancer risk syndromes from 21 centers...
Hereditary angioedema is an autosomal dominant disease characterized by recurrent attacks with the involvement of multiple organs.The unknown to many health professionals and therefore underdiagnosed.Patients who are not adequately diagnosed treated have estimated mortality rate ranging from 25% 40% due asphyxiation laryngeal angioedema.Intestinal another important incapacitating presentation that may be main or only manifestation during attack.In this article, a group experts ''Associac¸a...
Background Evans syndrome (ES) in childhood‐onset systemic lupus erythematosus (cSLE) patients has been rarely reported and limited to small populations. Procedures A retrospective multicenter cohort study (Brazilian cSLE group) was performed 10 Pediatric Rheumatology services including 850 with cSLE. ES assessed at disease diagnosis defined by the combination of immune thrombocytopenia autoimmune hemolytic anemia. Results observed 11 (1.3%) patients. The majority them had hemorrhagic...
Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, diagnosis's delay has strong impact on patient's quality of life. We analyzed clinical and laboratory characteristics drug therapy pediatric patients HAE Brazil.Medical records from 18 reference centers under years age were evaluated after confirmed diagnosis was performed by quantitative and/or functional C1-INH.A total 95 participants...
Prevention of attacks is a major goal in management patients with hereditary angioedema (HAE). We aimed to investigate the effects systematic intervention for HAE patients.Thirty-three C1-inhibitor deficiency, belonging single family, participated program coordinated by an allergist/immunologist. Angioedema before were ascertained interviews and emergency room charts recorded prospectively or caregivers after enrollment. Mean number attacks/month was compared at 12 months preintervention 8...
Objective To compare clinical, functional and immunological features between elderly asthmatics with long-standing asthma (LSA) those late-onset (LOA).
HAE with normal C1 inhibitor (HAE-nC1-INH) has been identified as a bradykinin mediated angioedema. Estrogens are one of the main trigger factors. Pregnancy in deficiency showed variable course, however, few reports available for HAE-nC1-INH. We evaluated course pregnancies women diagnosed HAE-nC1-INH.Women diagnosis HAE-nC1-INH according to following criteria: clinical manifestations similar HAE-C1-INH, biochemical evaluation and family history were included. A questionnaire about was...
Dear editor, DADA2 (deficiency of adenosine deaminase 2) is an inborn error immunity with variable clinical presentation, first described as a monogenic type vasculitis [1]. However, patients haematologic manifestations, like pure red cell aplasia (PRCA), bone marrow failure (BMF) and isolated cytopenias have been reported recently [2–4]. Haematologic autoimmune including haemolytic anaemia (AIHA) or immunomediated thrombocytopenias (ITP) are less frequently [4, 5]. Lee et al. provided new...
To evaluate prevalence, clinical manifestations, laboratory abnormalities, treatment and outcome in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients with without panniculitis. Panniculitis was diagnosed due to painful subcutaneous nodules and/or plaques deep dermis/subcutaneous tissues lobular/mixed panniculitis lymphocytic lobular inflammatory infiltrate skin biopsy. Statistical analysis performed using Bonferroni correction(p < 0.004). observed...
<b><i>Background:</i></b> Acquired angioedema due to C1 inhibitor deficiency (AAE-C1-INH) is a very rare disease. In clinical practice, it may be difficult differentiate AAE-C1-INH from hereditary C1-INH (HAE-C1-INH). both conditions, patients are at an increased risk of death asphyxiation upper airway obstruction. The association with lymphoproliferative and autoimmune diseases, presence anti-C1-INH antibodies has been well documented, treatment the underlying...
Pyomyositis is a pyogenic infection of skeletal muscle that arises from hematogenous spread and usually presents with localized abscess. This has been rarely reported in adult-onset systemic lupus erythematous and, to the best our knowledge, not diagnosed pediatric population. Among childhood-onset population, including 289 patients, one presented pyomyositis. patient was at age 10 years-old. After six years, while being treated prednisone, azathioprine hydroxychloroquine, she hospitalized...