A5082688538- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Anomalies
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Medical Imaging Techniques and Applications
- Protein Degradation and Inhibitors
- Polyomavirus and related diseases
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Plant Virus Research Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma Management and Diagnosis
- Temporomandibular Joint Disorders
- Vitamin D Research Studies
Southern Illinois University School of Medicine
2020-2024
American Head & Neck Society
2020-2024
Hawke's Bay Hospital
2023
University of Arkansas for Medical Sciences
2013-2022
TGS (United Kingdom)
2021
Mount Sinai Hospital
2021
University of Illinois at Springfield
2020
University of Arkansas at Little Rock
2010-2020
University of Arkansas Medical Center
2006-2019
Arkansas Department of Agriculture
2006-2015
Background: The primary goals of this interdisciplinary consensus statement are to review the relevant anatomy central neck compartment, identify nodal subgroups within compartment commonly involved in thyroid cancer, and define a consistent terminology dissection. Summary: most lymph nodes carcinoma prelaryngeal (Delphian), pretracheal, right left paratracheal basins. A dissection includes comprehensive, compartment-oriented removal pretracheal at least one node basin. designation should be...
Hypoparathyroidism (hypoPT) is the most common complication following bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. The objective of this American Association Surgical Affairs Committee Statement to provide an overview its diagnosis, prevention, treatment.HypoPT occurs when a low intact parathyroid hormone (PTH) level accompanied by hypocalcemia. Risk factors hypoPT include operations, autoimmune disease,...
Background: The role of prophylactic central lymph node dissection in papillary thyroid cancer (PTC) is controversial patients who have no pre- or intraoperative evidence nodal metastasis (clinically N0; cN0). controversy relates to its unproven reducing recurrence rates while possibly increasing morbidity (permanent hypoparathyroidism and unintentional recurrent laryngeal nerve injury). Methods Results: We examined the design feasibility a multi-institutional prospective randomized...
PURPOSE: Earlier detection of head and neck cancer recurrence may improve survival. We evaluated the ability [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) to detect in a prospective trial using sequential PET scans. PATIENTS AND METHODS: Serial posttherapy FDG-PET was prospectively performed 44 patients with stage III or IV cancer. twice during first posttreatment year (at 2 10 months after therapy) thereafter as needed. After therapy, were grouped, based on tissue...
The purpose of this publication was to inform surgeons as the modern state‐of‐the‐art evidence‐based guidelines for management recurrent laryngeal nerve invaded by malignancy through blending domains 1) surgical intraoperative information, 2) preoperative glottic function, and 3) real‐time electrophysiologic information. These generated International Neural Monitoring Study Group (INMSG) are envisioned assist clinical decision‐making process involved in during thyroid surgery incorporating...
PURPOSE The objective of this study was to determine the negative predictive value (NPV) positron emission tomography (PET)/computed (CT) for clinically N0 neck on basis dissection. METHODS Participants with newly diagnosed, first-time, head and squamous cell carcinoma (HNSCC) at least one side which dissection planned were included. A total 287 participants prospectively enrolled from 23 American College Radiology Imaging Network-qualified institutions. PET/CT compared findings RESULTS...
Abstract Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin currently with no cure. In this study, we have first demonstrated that c-Myc overexpression common in MCC. By targeting c-Myc, bromodomain inhibitors antitumor efficacy several preclinical human cancer models. Thus, interrogated role inhibition MCC amplification by using BET inhibitor JQ1. We uncovered can be regulated JQ1 cells pathologic activation. Moreover, potently abrogates expression and causes...
Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin cancer with no cure for metastatic disease. Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromatin. Super-enhancers of are identified enrichment H3K27Ac. BET inhibitor JQ1 disrupts BRD4 association super-enhancers, downregulates proto-oncogenes, such as c-Myc, and displays antitumor activity...
Objective To evaluate 4‐dimensional (4D) computed tomography (CT) for the localization of parathyroid adenomas previously considered nonlocalizing on ultrasound and single‐photon emission CT with scanning (SPECT‐CT). measure radiation exposure associated 4D‐CT compared it SPECT‐CT. Study Design Case series chart review. Setting University tertiary hospital. Subjects Methods Nineteen adults primary hyperparathyroidism who underwent preoperative 4D from November 2013 through July 2014 after...
Abstract Context Broad genomic analyses among thyroid histologies have been described from relatively small cohorts. Objective Investigate the molecular findings across a large, real-world cohort of fine-needle aspiration (FNA) samples. Design Retrospective analysis RNA sequencing data files. Setting Clinical Laboratory Improvement Amendments laboratory performing Afirma Genomic Sequencing Classifier (GSC) and Xpression Atlas (XA) testing. Participants A total 50 644 consecutive Bethesda...
There is epidemiologic evidence that the increasing incidence of thyroid cancer associated with subclinical disease detection. Evidence for a true increase in has also been identified. However, would likely be heralded by an increased thyroid-referable symptoms patients presenting disease.To evaluate whether modes detection (MODs) used to identify nodules surgical removal have changed compared historic data and determine if MODs vary geographic location.This was retrospective analysis...
New and more consistent biomarkers of head neck squamous cell carcinoma (HNSCC) are needed to improve early detection disease monitor successful patient management.To determine if a new proteomic technology can correctly identify protein expression profiles for cancer in serum samples as well detect the presence known tumor marker.Direct analysis comparison.The surface-enhanced laser desorption/ionization time flight mass spectrometry (SELDI-TOF) ProteinChip system was used screen...
Abstract Purpose: New and more consistent biomarkers of head neck squamous cell carcinoma (HNSCC) are needed to improve early detection disease monitor successful patient management. The purpose this study was determine whether a new proteomic technology could correctly identify protein expression profiles for cancer in serum samples. Experimental Design: Surface-enhanced laser desorption/ionization-time flight-mass spectrometry ProteinChip system used screen differentially expressed...
<h3>Objective:</h3> To compare the cost and functional results of free pedicled soft tissue reconstruction after posterior oral cavity oropharyngeal extirpation. <h3>Design:</h3> Retrospective study 53 consecutive patients undergoing extirpation with primary from January 1, 1991, to December 31, 1995. Median follow-up was 298 days. <h3>Setting:</h3> Academic tertiary care medical center. <h3>Intervention:</h3> Twenty-four underwent a pectoralis major myocutaneous flap (PMMF); 29 patients,...