A5101488055- Trace Elements in Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Peripheral Neuropathies and Disorders
- Cerebrospinal fluid and hydrocephalus
- Neurological and metabolic disorders
- Heavy Metal Exposure and Toxicity
- Neurological diseases and metabolism
- Autoimmune Neurological Disorders and Treatments
- Iron Metabolism and Disorders
- Virology and Viral Diseases
- Infectious Encephalopathies and Encephalitis
- Alcoholism and Thiamine Deficiency
- Pharmacological Effects and Toxicity Studies
- Folate and B Vitamins Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Neurological Complications and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Aluminum toxicity and tolerance in plants and animals
- Glycogen Storage Diseases and Myoclonus
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Leprosy Research and Treatment
King George's Medical University
2016-2025
University of Sassari
2016-2024
Mayo Clinic in Florida
2011-2024
Mayo Clinic
2010-2022
WinnMed
2003-2021
Mayo Clinic in Arizona
2008-2021
Jacksonville College
2021
Hamad Medical Corporation
2020
All India Institute of Medical Sciences Raipur
2019
All India Institute of Medical Sciences Bhopal
2019
To describe the phenotypes, treatment response, and outcome of IgLON5 autoimmunity.Archived serum CSF specimens from 367 patients known to harbor unclassified antibodies which stained neural synapses diffusely (mimicking amphiphysin-IgG) were reevaluated by indirect immunofluorescence assay (IFA) using a composite mouse tissues recombinant IgLON5-transfected cell-based (CBA, Euroimmun).Available (serum, 25; CSF, 9) 26/367 (7%) had identical IFA appearance robust CBA positivity. Clinical...
<b>Background: </b> Neurologic symptoms have been attributed to manganese fumes generated during welding. Increased T1 MRI signal in the basal ganglia is a biologic marker of accumulation. Recent studies associated welding and parkinsonism, but generally without corroboration. <b>Objective: To characterize clinical neuropsychological features patients with hyperintensity, who were ultimately diagnosed neurotoxicity from fumes. <b>Methods: The medical records welders referred Department...
Superficial siderosis (SS) of the CNS is caused by repeated slow hemorrhage into subarachnoid space with resultant hemosiderin deposition in subpial layers brain and spinal cord. Despite extensive investigations, cause bleeding frequently undetermined.To review clinical imaging features 30 consecutive patients SS provide insights underlying causes this disabling disorder.The authors reviewed medical records MRI evidence SS.The commonest neurologic manifestations included gait ataxia hearing...
Coronavirus disease 2019 (COVID-19) has been shown to be associated with a lot of neurological complications, whom Guillain-Barre syndrome (GBS) is an important post-infectious consequentiality. More than 220 patients GBS have reported thus far. We intend share our experience five where one them had severe acute respiratory coronavirus 2 (SARS-CoV-2) in the cerebrospinal fluid (CSF). This first-ever report demonstrating presence SARS-CoV-2 CSF adult patient; similar occurrence recently...
Abstract We assessed the 5‐year risk of levodopa‐induced dyskinesias by age Parkinson's disease (PD) onset in a population‐based cohort. The medical records linkage system Rochester Epidemiology project was used to identify residents Olmsted County, Minnesota, with incident PD for period 1976 through 1990. In this study, dyskinesia incidence declined age. With after 70 years age, 16%. from 40 59 higher at 50%. These data may overestimate functional importance, because patients minimal or...
Background:The threat of levodopa-induced dyskinesias often influences early treatment decisions in those with Parkinson disease.Objective: To determine the long-term risks levodopaassociated any severity, sufficient to require medication adjustment, and failing adjustments. Design:The medical records linkage system Rochester Epidemiology Project was used identify all incident disease patients treated levodopa (1976-1990).All were independently reviewed by 2 neurologists who recorded...
Pachymeningeal enhancement and brain sagging are recognized neuroimaging manifestations of craniospinal hypovolemia (CSH).1 Typically, CSF leaks from a dural defect, pools in the epidural space, is absorbed into veins. It subsequently seen as early radiotracer activity on cisternography or contrast renal pelvis CT myelography. Not infrequently, despite extensive investigations, defect not identified patients with CSH.2 Many these undergo repeated single multilevel blood patches limited benefit.
Background: Ataxic myelopathy due to copper deficiency has been described in ruminant animals and is called swayback.Neurological manifestations inherited secondary the failure of intestinal absorption well recognized as Menkes disease.The neurological consequences acquired humans are not described.Objective: To report 2 cases where patients developed a with after gastrointestinal surgery.
<h3>Background</h3> In humans, Menkes disease is the well-recognized neurological disorder due to inherited copper deficiency. Myelopathy acquired deficiency not a entity in although myelopathy well documented some animal species. <h3>Patients</h3> We describe 3 patients who developed progressive spastic-ataxic gait with proprioceptive deficits. All had severe reduction serum ceruloplasmin and levels. <h3>Results</h3> evidence of posterior column dysfunction clinically on somatosensory...
<b>Background: </b> Chronic liver failure may be associated with pallidal MRI T1 hyperintensity and heterogeneous neurologic syndromes, including parkinsonism, cognitive impairment, others. Manganese accumulation responsible for the imaging clinical findings. <b>Objective: To measure manganese plus other metal concentrations in pallidum additional brain regions to examine corresponding neuropathology cases of chronic failure. <b>Methods: Regional were measured seven cases, four three normal...
<h3>Background</h3> An atypical form of parkinsonism has been described in patients with chronic liver disease, associated increased T1 signal the basal ganglia on magnetic resonance imaging. The imaging changes are characteristic manganese accumulation, which neuropathologically confirmed. Manganese neurotoxicity may result additional neurologic findings besides parkinsonism. <h3>Objective</h3> To fully characterize central nervous system symptoms and failure hyperintensity. <h3>Design</h3>...