A5010685929- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Cellular transport and secretion
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- Porphyrin and Phthalocyanine Chemistry
- Lipid Membrane Structure and Behavior
- Endoplasmic Reticulum Stress and Disease
- Aquaculture disease management and microbiota
- Membrane Separation Technologies
- Viral Infections and Vectors
- Animal Virus Infections Studies
Oslo University Hospital
2017-2022
Norwegian Veterinary Institute
2022
University of Oslo
2017-2021
For optimal exploitation of nanoparticles (NPs) in biomedicine, and to predict nanotoxicity, detailed knowledge the cellular responses cell-bound or internalized NPs is imperative. The final outcome NP-cell interaction dictated by type magnitude NP insult response. Here, this has been systematically studied using poly(alkylcyanoacrylate) (PACA) particles differing only their alkyl side chains; butyl (PBCA), ethylbutyl (PEBCA), octyl (POCA), respectively. Surprisingly, these highly similar...
Infectious salmon anaemia virus (ISAV) binds circulating Atlantic erythrocytes, but the relevance of this interaction for course infection and development disease remains unclear. We here characterise ISAV-erythrocyte interactions in experimentally infected show that ISAV-binding to erythrocytes is common precedes disease. Viral RNA infective particles were enriched cellular fraction blood. While erythrocyte-associated ISAV remained infectious, dose-dependently limited cultured cells....
Nanoparticles composed of poly(alkyl cyanoacrylate) (PACA) have shown great promise due to their biodegradability and high drug loading capacity. Development optimal PACA nanocarriers requires detailed analysis the overall cellular impact exerted by variants. We here perform a comprehensive comparison cabazitaxel (CBZ)-loaded three different monomers, i.e. poly(n-butyl (PBCA), poly(2-ethylbutyl (PEBCA) poly(octyl (POCA). The cytotoxicity drug-loaded empty nanoparticles were compared that...
// Anders Øverbye 1, 2 , Ann Mari Holsæter 3 Markus Fusser 4 Nataša Škalko-Basnet Tore-Geir Iversen Maria Lyngaas Torgersen Tonje Sønstevold Olav Engebraaten 4, 5 Kjersti Flatmark Gunhild Mælandsmo 3, Tore Skotland and Kirsten Sandvig 2, 6 1 Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Norway Department Molecular Cell Biology, Institute Research, The Oslo Drug Transport Delivery Research Group, Pharmacy, Health Sciences, Tromsø – Arctic...
Nanoparticles (NPs) are used in our everyday life, including as drug delivery vehicles. However, the effects of NPs at cellular level and their impacts on autophagy poorly understood. Here, we demonstrate that NP vehicle poly(butyl cyanoacrylate) (PBCA) perturbs redox homeostasis human epithelial cells, degree perturbation dictates divergent PBCA autophagy. Specifically, promoted functional low concentrations, whereas it inhibited high concentrations. Both were completely abolished by...
Nanoparticle drug carriers trigger a variety of cellular stress responses, including ER and antioxidant but may also affect the intracellular degradative pathway autophagy. This can impose profound effects on delivery, treatment nanoparticle cytotoxicity. We recently demonstrated that even small variations in alkyl side chains poly(alkylcyanoacrylate) (PACA) carrier nanoparticles, namely butyl (PBCA), ethylbutyl (PEBCA), or octyl (POCA), differentially induce redox imbalance human cell...
Abstract For optimal exploitation of nanoparticles (NPs) in biomedicine, and to predict nanotoxicity, detailed knowledge on the cellular responses cell-bound or internalized NPs is imperative. The outcome NP-cell interaction dictated by type magnitude NP insult response. Here, we have systematically studied impact minor differences composition stress viability using highly similar poly(alkylcyanoacrylate) (PACA) particles. Surprisingly, PACA particles differing only their alkyl side chains;...