A5055401910- Orthopaedic implants and arthroplasty
- Titanium Alloys Microstructure and Properties
- Opportunistic and Delay-Tolerant Networks
- Mobile Ad Hoc Networks
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Metal and Thin Film Mechanics
- Cancer-related gene regulation
- Aluminum Alloys Composites Properties
- Oil and Gas Production Techniques
- Advanced Multi-Objective Optimization Algorithms
- Ferroptosis and cancer prognosis
- Corrosion Behavior and Inhibition
- Ubiquitin and proteasome pathways
- Hydraulic Fracturing and Reservoir Analysis
- Epigenetics and DNA Methylation
- Mass Spectrometry Techniques and Applications
- Cellular Mechanics and Interactions
- Drilling and Well Engineering
- Probabilistic and Robust Engineering Design
- Reservoir Engineering and Simulation Methods
- Welding Techniques and Residual Stresses
- Wireless Networks and Protocols
- Metabolism, Diabetes, and Cancer
- Hippo pathway signaling and YAP/TAZ
Southwest Petroleum University
2021-2024
Uppsala University
2019-2023
Northeastern University
2021
China National Petroleum Corporation (China)
2021
Pusan National University
2016-2020
University of Electronic Science and Technology of China
2020
Jinan University
2012-2018
High rates of glucose transport via solute carrier (SLC2A, GLUT) family members are required to satisfy the high metabolic demands cancer cells, and because this characteristic cells 2-18fluoro-deoxy-D-glucose (18FDG)-PET has become a powerful diagnostic tool. However, its sensitivity for hepatocellular carcinoma (HCC) is lower than other malignancies, which suggests SLC2A differentially expressed in HCC. In present study, expression patterns tumor tissues their associations with HCC...
Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase produce sufficient PtdIns-4-phosphate (PtdIns-4-P) the trans-Golgi network promote maturation. PITPNA beta-cells T2D human subjects is markedly reduced suggesting its depletion accompanies dysfunction. Conditional deletion Pitpna Ins-Cre,
Single-cell metabolomics has the potential to reveal unique insights into intracellular mechanisms and biological processes. However, detection of metabolites from individual cells is challenging due their versatile chemical properties concentrations. Here, we demonstrate a tapered probe for pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI) mass spectrometry that enables both imaging larger global smaller 15 μm cells. Additionally, by depositing in predefined...
Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, ZHX3. Although ZHX members have been associated with the progression of cancer, their values as prognostic factors in cancer patients poorly examined. Renal cell carcinoma (RCC) highly heterogeneous, aggressive responds variably to treatment. Thus, molecular markers are required evaluate disease improve survival. In clear RCC (ccRCC), ZHX1 ZHX3 expression were found be...
Accurate prediction of prognosis is critical for therapeutic decisions regarding cancer patients. Many previously developed prognostic scoring systems have limitations in reflecting recent progress the field biology such as microarray, next-generation sequencing, and signaling pathways. To develop a new system patients, we used mRNA expression clinical data various independent breast cohorts (n=1214) from Molecular Taxonomy Breast Cancer International Consortium (METABRIC) Gene Expression...
Targeted and nontargeted metabolomics has the potential to evaluate detect global metabolite changes in biological systems. Direct infusion mass spectrometric analysis enables detection of all ionizable small molecules, thus simultaneously providing information on both metabolites lipids chemically complex samples. However, unravel heterogeneity metabolic status cells culture tissue a low number per sample should be analyzed with high sensitivity, which requires volumes. Here, we present...
The efficiency represented by the computational costs for solving complex engineering optimization problems can be improved based on surrogate models. Adaptive sampling methods effectively reduce number of samples and enhance accuracy model. However, from perspective optimization, most adaptive ignore inevitable connection between process establishment a existing are poor. In this paper, novel method is proposed (CM). method, used not only to establish model but also form shapes guide...
Zinc-fingers and homeoboxes 1 (ZHX1) is a nuclear transcription repressor known to be involved in cell differentiation tumorigenesis. However, the pathophysiological roles of ZHX1 have not been characterized glioblastoma. We examined expression glioblastoma patients’ tissues analyzed overall survival patients based on level ZHX1. also effects proliferation motility cells. In silico analysis immunohistochemical studies showed that messenger RNA protein expressions were higher than normal...
Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, breast cancer. However, functional roles ZHX1 in cholangiocarcinoma (CCA) have not determined. We investigated expression during proliferation, migration, invasion CCA cells. In silico analysis immunohistochemical studies showed amplification overexpression tissues. Furthermore, knockdown using specific siRNAs decreased cell invasion,...
Integrin-mediated adhesion to the extracellular matrix is a key regulator of cell cycle, as demonstrated for passage G1/S checkpoint and completion cytokinetic abscission. Here, integrin-dependent regulation cycle in G2 early M phases was investigated. The progression through monitored by live-cell imaging immunofluorescence staining adherent non-adherent fibroblast cells. Non-adherent cells, well cells lacking FAK activity due suppressed expression or pharmacological inhibition, exhibited...
The surface of titanium and alloys can easily form a Ti-OH bond by absorbing water to induce apatite nucleation, shows good biological activity osseointegration ability, which is especially suitable for bone implantation. In this study, calcium-phosphorus-containing ceramic coating was prepared on non-toxic alloy -Ti-3Zr-2Sn-3Mo-25Nb (TLM) – using micro-arc oxidation treatment, accompanied doping NaF as additive. Micro-morphology, phase composition, pH value, contact angle clotting time were...
Integrin-mediated adhesion is normally required for cytokinetic abscission, and failure in the process can generate potentially oncogenic tetraploid cells. Here, detachment-induced formation of cells was analyzed non-transformed human BJ fibroblasts expressing SV40LT (BJ-LT) ± overactive HRas. In contrast to BJ-LT cells, non-adherent BJ-LT-Ras recruited ALIX CHMP4B midbody divided. detached regression furrow suppressed by intercellular bridge-associated septin; after re-adhesion these...
This article mainly describes the Ad hoc on-demand QoS routing based on Bandwidth Prediction (AQBP). Differing from existing protocols, AQBP takes node future bandwidth into consideration when selects route. The requirement of each is predicted by its history. performances throughput, transmission ratio and delay among AODV, AQOR have been simulated. Moreover, results represent that reduces possibility route change during transmission, thus performs a higher throughput than counterpart...
Mobile multimedia applications have recently attracted numerous interests in mobile ad hoc networks (MANETs) supporting quality-of-service (QoS) communications. Multiple non-interfering channels are available 802.11- and 802.15-based wireless networks. Channel assignment depends on the bandwidth at involved nodes consumption required by a new flow. Predicting of node is challenging due to shared open nature channel. This paper proposes traffic-predictive QoS on-demand routing(TPQOR) protocol...
A Simulated Body Fluid (SBF) treatment was performed to modify the surface of a TiO2-based coating containing Ca and P prepared by micro-arc oxidation (MAO). Scanning electron microscopy (SEM), X-ray diffraction (XRD), X-Ray Photoelectron Spectroscopy (XPS) were employed characterise composition morphology immersed Ca-P coating. The primarily presents porous structure, which is mainly composed anatase, rutile, CaP, Nb2O5.The biological activity determined immersing in SBF for 5 days, showing...
The evaluation and management of sustaining casing pressure (SCP) in injection/production wells underground gas storage(UGS) is an important part the wellbore integrity. SQ storage has experienced ten complete cycles, which puts forward high requirements on well At present, there are different degrees SCP UGS, seriously threatens safety UGS. This paper analyzes injection/ production stages working conditions wells, combined with API RP 90-2, NORSOK, ISO/TS 16530-2, SY/T5724-2008 standards....
SUMMARY Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase produce sufficient PtdIns-4-phosphate (PtdIns-4-P) the trans-Golgi network promote maturation. PITPNA beta-cells T2D human subjects is markedly reduced suggesting its depletion accompanies dysfunction. Conditional deletion Pitpna Ins -Cre;...