A5068451219- Rabies epidemiology and control
- Viral Infections and Outbreaks Research
- Parasitic Diseases Research and Treatment
- Virology and Viral Diseases
- Olfactory and Sensory Function Studies
- Salmonella and Campylobacter epidemiology
- Food Safety and Hygiene
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- Microbial infections and disease research
- Yersinia bacterium, plague, ectoparasites research
- Mycobacterium research and diagnosis
- Viral Infections and Vectors
- Parasites and Host Interactions
- Listeria monocytogenes in Food Safety
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Streptococcal Infections and Treatments
- COVID-19 and Mental Health
Institut Pasteur
2020-2024
Université Paris Cité
2021-2022
Sorbonne Paris Cité
2021
Institut Pasteur Korea
2021
Délégation Paris 7
2021
Article12 July 2021Open Access Source DataTransparent process Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin Guilherme Dias de Melo orcid.org/0000-0003-0747-7760 Lyssavirus Epidemiology Neuropathology Unit, Institut Pasteur, Paris, France Search for more papers this author Françoise Lazarini orcid.org/0000-0001-5572-6982 Perception Memory CNRS UMR 3571, Florence Larrous orcid.org/0000-0003-0881-4263 Lena Feige Etienne Kornobis Biomics...
The devastating coronavirus disease 2019 (COVID-19) pandemic, due to SARS-CoV-2, has caused more than 47 million confirmed cases and 1.2 human deaths around the globe 1 , most of severe COVID-19 in humans are associated with neurological symptoms such as anosmia ageusia, uncontrolled inflammatory immune response 2–5 . Among therapeutic options 6–8 use anti-parasitic drug ivermectin (IVM), been proposed, given its possible anti-SARS-CoV-2 activity 9 Ivermectin is a positive allosteric...
Listeria monocytogenes can cause severe illness in individuals with weakened immune systems. In March 2023, L. was isolated from blood (n = 2) or pleural fluid 1) of three febrile patients receiving synthetic glucocorticoids a tertiary hospital Germany. Food supply records suggested sliced parboiled sausage as the likely source, and four samples sealed packaged sausages ham one manufacturer. The patient food isolates clustered within 0–4 allelic differences. Counts all were < 100...
Rabies is caused by neurotropic rabies virus (RABV), contributing to 60,000 human deaths annually. Even though leads major public health concerns worldwide, we still do not fully understand factors determining RABV tropism and why glial cells are unable clear from the infected brain. Here, compare susceptibilities immune responses of CNS cell types infection with two strains, Tha its attenuated variant Th2P-4M, mutated on phospho- (P-protein) matrix protein (M-protein). We demonstrate that...
Rabies is a zoonotic disease caused by rabies virus (RABV). As advances, patients develop variety of severe neurological symptoms that inevitably lead to coma and death. Unlike other neurotropic viruses can induce similar range, RABV-infected post-mortem brains do not show significant signs inflammation nor the structural damages on neurons. This suggests observed possibly originate from dysfunctions However, many aspects neuronal in context RABV infection are only partially understood,...
Rabies virus (RABV), the causative agent for rabies disease is still presenting a major public health concern causing approximately 60,000 deaths annually. This neurotropic (genus Lyssavirus , family Rhabdoviridae ) induces an acute and almost always fatal form of encephalomyelitis in humans. Despite lethal consequences associated with clinical symptoms rabies, RABV limits neuro-inflammation without histopathological lesions Nevertheless, information about mechanisms infection cellular...
Abstract Viral tropism, or the specificity of a particular virus to infect certain cell type, is crucial in determining replication, viral spread, and ultimately host survival. Rabies, one deadliest known zoonotic diseases, still causing 60.000 human deaths annually. Upon central nervous system (CNS) entry, neurotropic rabies (RABV) preserves neural network by limiting apoptosis inflammation. To date, we do not fully understand factors RABV tropism why glial cells are unable clear from...
Rabies virus (RABV) proteins play dual roles during the infection of complex neural tissue, generation and spread new virions active inhibition cellular innate immune pathways, both contributing to rabies lethality. While spatially-distinct RABV protein residues specializing in virus-centric immune-inhibitory functions have been identified, how these interact shape outcomes across diverse types host brain cells is unknown. To 'unmask' study affects transcriptional regulation human viral...