A5065302111- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Atrial Fibrillation Management and Outcomes
- Asthma and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Climate Change and Health Impacts
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Gastric Cancer Management and Outcomes
- Gestational Diabetes Research and Management
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Cytokine Signaling Pathways and Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Eosinophilic Esophagitis
- Antibiotic Resistance in Bacteria
- Birth, Development, and Health
- Cancer Immunotherapy and Biomarkers
- Mangiferin and Mango Extracts
- Renal Transplantation Outcomes and Treatments
Changzhou No.2 People's Hospital
2018-2024
Nanjing Medical University
2007-2024
Qujing Normal University
2023
Chinese Research Academy of Environmental Sciences
2022-2023
Affiliated Hospital of Nantong University
2020-2022
Nantong University
2020-2022
Dalian Medical University
2018-2021
Chongqing Medical University
2018-2021
Second Affiliated Hospital of Chongqing Medical University
2018-2021
Jiangsu Province Hospital
2007-2021
Cognitive impairments are prominent sequelae of prolonged continuous seizures (status epilepticus; SE) in humans and animal models. While often associated with dendritic injury, the underlying mechanisms remain elusive. The mammalian target rapamycin complex 1 (mTORC1) pathway is hyperactivated following SE. This modulates learning memory regulation neuronal, dendritic, glial properties. Thus, present study we tested hypothesis that SE-induced mTORC1 hyperactivation a candidate mechanism...
Epithelial-mesenchymal transition (EMT) is essential in asthma airway remodeling. IL-33 from epithelial cells involved pulmonary fibrosis. CD146 has been extensively explored cancer-associated EMT. Whether regulates the EMT process associated with remodeling still largely unknown. We hypothesized that was regulated by IL-33/CD146 axis. House dust mite (HDM) extract increased expression of and cells. Increased HDM-treated could be blocked an ST2-neutralizing antibody. Moreover, HDM-induced...
Background/Aims: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. This study aimed to identify overlapping or diverging dysregulated genes, lncRNAs, miRNAs signaling pathways in smoking non-smoking chronic (COPD). Methods: Compared normal controls, we identified the shared divergent differentially expressed mRNAs (DEmRNAs), (DEmiRNAs) lncRNAs (DElncRNAs) COPD by RNA-sequencing bioinformatics analysis. Functional annotation DEmRNAs were...
Abstract Since airway hyperresponsiveness (AHR) and allergic inflammatory changes are regarded as the primary manifestations of asthma, main goals asthma treatment to decrease inflammation maximize bronchodilation. These can be achieved with aerosol therapy. Intravenous administration anesthetic, ketamine, has been shown trigger bronchial smooth muscle relaxation. Furthermore, increasing evidence suggests that anti-inflammatory properties ketamine may protect against lung injury. However,...
Persistent activation of nuclear factor κB (NF-κB) has been associated with the development asthma. Galangin, active pharmacological ingredient from Alpinia galanga, is reported to have a variety anti-inflammatory properties in vitro via negative regulation NF-κB. This study aimed investigate whether galangin can abrogate ovalbumin- (OVA-) induced airway inflammation by BALB/c mice sensitized and challenged OVA developed hyperresponsiveness (AHR) inflammation. Galangin dose dependently...
Aim: This study aimed to explore the molecular mechanism of severe asthma. Materials & methods: The shared and divergent differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs) lncRNAs (DElncRNAs) in asthma were identified by RNA-sequencing. Severe asthma-specific DEmiRNA–DEmRNA–DElncRNA interaction networks performed. Results: Compared with normal control, 1328 DEmRNAs, 608 DElncRNAs 63 DEmiRNAs asthma, 95 143 96 MiR-133a-3p-EFHD2/CNN2-AC144831.1 interactions...
The IL-33/ST2 axis has been extensively investigated in type 2 eosinophilic inflammation. Here, we aimed to investigate the role of neutrophil-dominant allergic airway inflammation.House-dust mite (HDM) extract and lipopolysaccharide (LPS) were administered establish a murine model formation neutrophilic extracellular traps (NETs) lung tissues was demonstrated by immunofluorescence imaging. Mature IL-33 bronchoalveolar lavage fluid (BALF) detected Western blotting. chemokine KC produced bone...
Both fine particulate matter (PM2.5) and ozone (O3) may have adverse effects on human health. However, previous studies the of air pollutants mainly focused susceptible population, evidence healthy young adults is limited. We aimed to examine associations two main (PM2.5 O3) with lung function, inflammation oxidative stress in adults. recruited 30 for a longitudinal panel study Beijing implemented health examination seven times, including function (FEV1 PEF) biomarkers (i.e. C-reactive...
Abstract Background China proposed the Zero Markup Drug Policy (ZMDP), which popularized in tertiary hospitals across country 2017, to control drug expenditures’ rapid growth further and reduce public’s medical burden. This study aims evaluate impact of ZMDP on cost chronic disease outpatients hospital Chongqing. Methods We collected described drug-cost data for with diseases a Chongqing’s from 2015 2019. The instantaneous long-term changes outpatient volume average after were evaluated...
The diagnosis of severe asthma (SA) is difficult due to a necessary long-term treatment history currently, while there are few studies on biomarkers in the SA. Long non-coding RNA (lncRNA) growth arrest specific-5 (GAS5) has potential playing this role because its binding with glucocorticoid receptor (GR). purpose article explore possibility lncRNA GAS5 acting as biomarker for early (SA).Peripheral blood was obtained from healthy volunteers, patients non-severe (nSA) and SA, peripheral...
The management of patients receiving warfarin is complicated. This study evaluated the anticoagulation quality warfarin, explored potential predictors associated with poor quality, and elucidated role clinical pharmacists in treatment.
Grape seed proanthocyanidin extract (GSPE) is effective in treating severe asthma (SA).To examine the relationship between Nrf2-miR-29b axis and SA, to detect whether preventive use of GSPE relieves SA via it.We recruited 10 healthy controls, patients with non-severe (nSA), 9 from February 2017 December 2017. Peripheral blood mononuclear cells these volunteers were extracted. A murine model steroid-insensitive was established six-week-old female BALB/c mice that sensitised challenged OVA,...
Epithelial-mesenchymal transition (EMT) is known to be involved in airway remodeling and fibrosis of bronchial asthma.However, the molecular mechanisms leading EMT have yet fully clarified.The current study was designed reveal potential mechanism microRNA-21 (miR-21) poly (ADP-ribose) polymerase-1 (PARP-1) affecting through PI3K/AKT signaling pathway.Human epithelial cells (16HBE cells) were transfected with miR-21 mimics/inhibitors PARP-1 plasmid/small interfering RNA (siRNA).A dual...
Background Acute lung injury (ALI) usually has a high morbidity and mortality rate, but the current treatment is relatively scarce. Both budesonide (Bud) N-acetylcysteine (NAC) exhibit protective effects in ALI, so we further investigated whether they have synergistic effect on ALI when used together. Methods Establishment of rat model with Lipopolysaccharide (LPS). Bud NAC were administered by nebulized inhalation alone or combination. Subsequently, HE staining was performed to observe...
To compare the effects of postoperative patient-controlled intravenous analgesia (PCIA) with morphine, tramadol, or tramadol combined lornoxicam on serum inflammatory cytokine production.60 patients an American Society Anesthesiologists (ASA) physical status I II, undergoing radical correction gastric cancer, were equally randomized to receive PCIA morphine (M group), (T (L group). The visual analog scale (VAS) and Bruggemann comfort (BCS) scores used evaluate analgesic efficacy. Serum...
Autophagy exerts a vital role in the progression of lung squamous cell carcinoma (LUSC). Ubiquitin-specific peptidase 31 (USP31) has recently been found to be involved development variety cancers. However, whether USP31 modulates autophagy LUSC remains unclear.
Poor time in therapeutic range (TTR) control is associated with an increased risk of stroke and bleeding atrial fibrillation (AF) patients receiving warfarin. This study aimed to determine whether the physician-pharmacist collaborative clinic (PPCC) model could improve anticoagulation quality as well create a nomogram for predicting AF patients.