A5028342909- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Emergency and Acute Care Studies
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- COVID-19 diagnosis using AI
- Pneumonia and Respiratory Infections
- Cardiac Arrest and Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- Airway Management and Intubation Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Facial Nerve Paralysis Treatment and Research
- Phonocardiography and Auscultation Techniques
- Ultrasound and Hyperthermia Applications
- Hospital Admissions and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Enhanced Recovery After Surgery
- Neuroendocrine Tumor Research Advances
- Biosimilars and Bioanalytical Methods
Penn State Milton S. Hershey Medical Center
2025
Hôpital Nord
2020-2023
Aix-Marseille Université
2020-2023
Assistance Publique Hôpitaux de Marseille
2020-2022
Institut de Recherche pour le Développement
2020-2021
Hospital Universitario del Vinalopó
2020-2021
Méditerranée Infection Foundation
2020-2021
Hôpitaux Universitaires Paris-Ouest
2019
Université Paris-Sud
2019
Hospital Universitario Fundación Jiménez Díaz
2002-2015
An unbiased approach to SARS-CoV-2-induced immune dysregulation has not been undertaken so far. We aimed identify previously unreported markers able discriminate COVID-19 patients from healthy controls and predict mild severe disease.An observational, prospective, multicentric study was conducted in with confirmed mild/moderate (n = 7) 19) COVID-19. Immunophenotyping of whole-blood leukocytes performed upon hospital ward or intensive care unit admission 25). Clinically relevant associations...
Abstract Background Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultrasound device for immediate point-of-care (POCUS) examination at bedside may team performance. The main objective study was assess impact implementing such POCUS-guided on proportion adequate diagnoses two groups. Secondary endpoints included time treatment patient...
Abstract Background Dexamethasone decreases mortality in patients with severe coronavirus disease 2019 (COVID-19) and has become the standard of care during second wave pandemic. is an immunosuppressive treatment potentially increasing risk secondary hospital acquired infections critically ill patients. We conducted observational retrospective study three French intensive units (ICUs) comparing first waves pandemic to investigate role dexamethasone occurrence ventilator-associated pneumonia...
Background: Postoperative pulmonary complications are associated with increased morbidity. Identifying patients at higher risk for such may allow preemptive treatment. METHODS: Patients an American Society of Anesthesiologists (ASA) score >1 and who were scheduled major surgery >2 hours enrolled in a single-center prospective study. After extubation, lung ultrasound was performed after median time 60 minutes by 2 certified anesthesiologists the postanesthesia care unit standardized...
Abstract Background Following the introduction of subcutaneous vedolizumab (VDZ-sc), which demonstrated efficacy in maintaining remission after two intravenous (iv) induction doses, a real-world approach was proposed to switch stable patients undergoing (VDZ-iv) treatment formulation. Aims To prospectively evaluate from VDZ-iv VDZ-sc IBD receiving maintenance therapy with VDZ-iv. Methods A prospective study conducted across three centers, including on who opted and consented participate....
Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is increasing interest, their role still unclear. We analyzed a large aPL panel 157 patients with according to disease severity. also investigated potential association between and extracellular DNA (exDNA, n = 85) or circulating markers neutrophil traps (NET) such as citrullinated histones H3 (CitH3, 49). A total sera infected by SARS-CoV-2 were collected. including lupus anticoagulant, anti-cardiolipin anti-beta-2...
Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and strongly associated mortality. The aim of this multicentric study was to assess impact specific treatments ARDS on risk AKI patients. Methods: In cohort study, data from consecutive older than 18 years admitted 6 ICUs for COVID-19-related requiring invasive mechanical ventilation were included. incidence severity AKI,...
Patients undergoing mechanical ventilation (MV) for COVID-19 exhibit an increased risk of ventilator-associated pneumonia (VAP). The occurrence lung abscesses following VAP in these patients has been poorly studied. We aimed to describe the incidence, characteristics, factors and prognosis complicating after COVID-19.We conducted observational, retrospective study three French intensive care units. admitted acute respiratory failure with a confirmed SARS-CoV-2 PCR requiring MV more than 48 h...
Background: High incidence of ventilator associated pneumonia (VAP) has been reported in critically ill patients with COVID-19. Among these patients, we aimed to assess the incidence, outcomes and risk factors VAP recurrences. Methods: We conducted an observational retrospective study three French intensive care units (ICUs). Patients admitted for a documented COVID-19 from March 2020 May 2021 requiring mechanical ventilation (MV) ≥48 h were included. The main outcome was Secondary duration...
Abstract Background Rib fractures occur frequently following blunt chest trauma and induce morbidity mortality. Analgesia is a cornerstone for their management, regional analgesia one of the tools available to reach this objective. Epidural paravertebral blocks are classical techniques used, but serratus plane block ( SPB ) has recently been described as an effective technique thoracic analgesia. Methods This case series reported analyzed 10 consecutive cases in level 1 center from May...
Background An association was reported between the left ventricular longitudinal strain (LV-LS) and preload. LV-LS reflects cardiac function curve as it is ratio of shortening over diastolic dimension. The aim this study to determine sensitivity specificity variations after a passive leg raising (PLR) maneuver predict fluid responsiveness in intensive care unit (ICU) patients with acute circulatory failure (ACF). Methods Patients ACF were prospectively included. Preload-dependency defined...
Q fever, a zoonosis caused by Coxiella burnetii, affects more males than females despite similar level of exposure. A protective role estradiol has been reported in mice, suggesting that sex hormones are involved C. burnetii infection. We wondered whether the responses monocytes and monocyte-derived macrophages (MDMs) to influenced hormones.The bacterial intracellular fate was studied using quantitative PCR, monocyte cytokine production response assessed qRT-PCR immunoassays. Before...
Physiotherapy is a major cornerstone of enhanced rehabilitation after surgery (ERAS) and reduces the development atelectasis thoracic surgery. By initiating physiotherapy in post-anaesthesia care unit (PACU), aim was to evaluate whether ultra-early initiation (in first hour following tracheal extubation) would improve outcomes patients undergoing elective
Abstract BackgroundKidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and strongly associated mortality. The aim of this multicentric study was to assess impact specific treatments ARDS on risk kidney injury (AKI) patients.MethodsIn cohort study, data from consecutive hospitalized 6 ICUs for were retrospectively collected. incidence severity AKI monitored during entire ICU stay. Patients older...
LUS is a validated tool for the management of COVID-19 pneumonia. Chair positioning (CP) may have beneficial effects on oxygenation and lung aeration, be an easier alternative to PP. This study assessed CP session aeration (LA) changes in non-intubated patients.A retrospective multicenter was conducted ICU. We analyzed data from exams SpO2:FiO2 performed before/after patients. Patients were divided into groups responders or non-responders terms LA.Thirty-three patients included study;...