A5088659328- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- Mass Spectrometry Techniques and Applications
- Cassava research and cyanide
- Traditional and Medicinal Uses of Annonaceae
- Genomics and Phylogenetic Studies
- Sesquiterpenes and Asteraceae Studies
- Phytochemical compounds biological activities
- Computational Drug Discovery Methods
- Psychedelics and Drug Studies
- Ecology and Vegetation Dynamics Studies
- Plant Diversity and Evolution
- Biochemical Analysis and Sensing Techniques
- Gut microbiota and health
- Polyamine Metabolism and Applications
- Plant and animal studies
- Molecular spectroscopy and chirality
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
University of Alberta
2021-2024
Secretaría de Investigación, Innovación y Educación Superior
2016-2020
Universidad Nacional de Asunción
2012
Abstract The Human Metabolome Database or HMDB (https://hmdb.ca) has been providing comprehensive reference information about human metabolites and their associated biological, physiological chemical properties since 2007. Over the past 15 years, grown evolved significantly to meet needs of metabolomics community respond continuing changes in internet computing technology. This year's update, 5.0, brings a number important improvements upgrades database. These should make more useful...
Abstract The Natural Products Magnetic Resonance Database (NP-MRD) is a comprehensive, freely available electronic resource for the deposition, distribution, searching and retrieval of nuclear magnetic resonance (NMR) data on natural products, metabolites other biologically derived chemicals. NMR spectroscopy has long been viewed as ‘gold standard’ structure determination novel products metabolites. also widely used in product dereplication characterization biofluid mixtures (metabolomics)....
Cannabis is widely used for medicinal and recreational purposes. As a result, there increased interest in its chemical components their physiological effects. However, current information on cannabis chemistry often outdated or scattered across many books journals. To address this issue, we modern metabolomics techniques bioinformatics to compile comprehensive list of >6000 constituents commercial cannabis. The methods included combination high- low-resolution liquid chromatography–mass...
The biosynthesis of lupeol-3-(3'R-hydroxy)-stearate (procrim b, 1) was investigated in the Mexican medicinal plant Pentalinon andrieuxii by (13)CO2 pulse-chase experiments. NMR analyses revealed positional enrichments (13)C2-isotopologues both triterpenoid and hydroxystearate moieties 1. Five six isoprene units reflected a pattern with [1,2-(13)C2]- [3,5-(13)C2]-isotopologues from respective C5-precursors, IPP DMAPP, whereas one unit ring E 1 showed only [3,5-(13)C2]-connectivity original...
Despite decades of study, large parts the mammalian metabolome remain unexplored. Mass spectrometry-based metabolomics routinely detects thousands small molecule-associated peaks within human tissues and biofluids, but typically only a fraction these can be identified, structure elucidation novel metabolites remains low-throughput endeavor. Biochemical language models have transformed interpretation DNA, RNA, protein sequences, not yet had comparable impact on understanding molecule...
Age in wild plant populations is one of the most elusive developmental parameters biology. Several approaches take advantage a plant’s morphological traits to determine stages or age. Annual growth rings forming woody tissues perennial plants are that have been widely used age trees (dendrochronology) and, more recently, herbaceous perennials (herb-chronology). In temperate, alpine, and arctic climates, it has reported seasonal variations climate lead formation annual forbs; however, date,...
Pentalinon andrieuxii ( Müll . Arg .) B.F. Hansen & Wunderlin (Apocynaceae) is a vine native to the Yucatan peninsula, where it widely used in Mayan traditional medicine treat, among other ailments, wounds caused by cutaneous leishmaniasis. Among secondary metabolites isolated from P are triterpene betulinic acid and chemically unusual tri‐norsesquiterpene urechitol A; however, date, there no existing knowledge about accumulation dynamics of ubiquitous or novel A plant. In this article,...