A5020291957- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Cell death mechanisms and regulation
- Biomedical Research and Pathophysiology
Columbia University
2019-2021
Genomics (United Kingdom)
2021
Columbia University Irving Medical Center
2018
Stony Brook University
2014-2016
Multiple genome-wide association studies (GWAS) have identified SNPs in the 8q24 locus near TRIB1 that are significantly associated with plasma lipids and other markers of cardiometabolic health, prior revealed roles hepatic myeloid Trib1 lipid regulation atherosclerosis. The same additionally adiponectin levels humans, implicating adipocyte biology. Here, we hypothesize adipose tissue regulates adiponectin, lipids, metabolic health. We investigate phenotype adipocyte-specific knockout mice...
Multiple GWAS have identified SNPs near the gene Tribbles-1 ( TRIB1 ) that significantly associate with coronary artery disease and plasma lipid traits, implicating pseudokinase in metabolism disease. The same human adiponectin levels, further implying a role for adipose tissue. Functional studies mice shown hepatic Trib1 regulates via transcription factor Cebpα, but few investigated adipocyte-specific Trib1. Thus, we developed knockout (ASKO) by crossing Trib1-floxed AdipoQ-Cre mice....
Abstract Multiple GWAS have identified SNPs in the 8q24 locus near TRIB1 gene that significantly associate with plasma lipids and coronary artery disease. While subsequent studies uncovered roles for hepatic myeloid Trib1 contributing to either or atherosclerosis, causal tissue these associations remains unclear. The same adiponectin levels humans as well, suggesting a role adipose tissue. Here, we report adipocyte-specific knockout mice (Trib1_ASKO) increased decreased cholesterol...
CCAAT/enhancer-binding protein alpha (C/EBPa) is a transcription factor known to mediate glucose and lipid metabolism. Hepatic levels of C/EBPa are controlled by the pseudokinase Tribbles-1 ( TRIB1 ), gene which has repeatedly been linked plasma lipids coronary artery disease human genome-wide association studies. Previous work shown that genetic perturbation hepatic Trib1 in mice alters lipids. However, it unknown if governs relationship between To investigate this, we first reasoned does...