A5040897206- Thermoregulation and physiological responses
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Sports Performance and Training
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Exercise and Physiological Responses
- Neonatal Respiratory Health Research
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Sports injuries and prevention
- Cardiovascular and exercise physiology
- High Altitude and Hypoxia
- Infrared Thermography in Medicine
- Climate Change and Health Impacts
- Body Composition Measurement Techniques
- Autophagy in Disease and Therapy
- Electrolyte and hormonal disorders
- Foot and Ankle Surgery
- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Lower Extremity Biomechanics and Pathologies
- Sports Dynamics and Biomechanics
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Inhalation and Respiratory Drug Delivery
Sonoma State University
2015-2023
University of Florida
2012-2019
Liverpool John Moores University
2015
U.S. Army Research Institute of Environmental Medicine
2010-2014
Deutsche Forschungsgemeinschaft
2013
European Society of Radiology
2013
National Institutes of Health
2013
United States Army
2010-2012
United States Department of the Army
2012
Southern Connecticut State University
2008-2011
Key points Although doxorubicin is a highly effective anti‐tumour agent, the administration of this drug associated with significant side effects, including contractile dysfunction and myopathy both cardiac skeletal muscles. The mechanism(s) responsible for doxorubicin‐induced in muscles remains unclear. In present study, we report that increased mitochondrial oxidant production calpain activation are major contributors to development myopathy. Moreover, treatment mitochondrial‐targeted...
Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, respiratory muscle weakness thought to contribute significantly delayed weaning patients. Therefore, therapeutic strategies for preventing these processes may have clinical benefit. The aim current study was investigate role Janus kinase (JAK)/signal transducer activator transcription 3 (STAT3) signaling pathway in CMV-mediated wasting rats. CMV-induced dysfunction...
This study investigated the effects of endurance exercise training on ileum antioxidant status, as well tight junction, inflammatory, and nutrient transporter gene expression. Sprague–Dawley rats (4 month old) were assigned to sedentary (SED) or exercise-training (EXE) groups (n = 8/group). EXE animals trained treadmill for 10 days at a speed 30 m/min 0° incline 60 min/day. SED sacrificed (24 h after final bout) was stored analyses. The had higher (p < 0.05) protein levels manganese...
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of diaphragmatic atrophy and weakness. Importantly, endurance exercise training phenotype that protected against ventilator-induced The mechanisms responsible this exercise-induced protection remain unknown. Therefore, to investigate changes diaphragm muscle proteins, we compared proteome from sedentary exercise-trained rats. Specifically,...
Objectives: Mechanical ventilation is a lifesaving measure for patients with respiratory failure. However, prolonged mechanical results in diaphragm weakness, which contributes to problems weaning from the ventilator. Therefore, identifying signaling pathways responsible ventilation–induced weakness essential developing effective countermeasures combat this important problem. In regard, forkhead boxO family of transcription factors activated during ventilation, and boxO–specific can lead...
Abstract Background Mechanical ventilation (MV) is a life‐saving measure for patients in respiratory failure. However, prolonged MV results significant diaphragm atrophy and contractile dysfunction, condition referred to as ventilator‐induced dysfunction (VIDD). While there are currently no clinically approved countermeasures prevent VIDD, increased expression of heat shock protein 72 (HSP72) has been demonstrated attenuate inactivity‐induced muscle wasting. HSP72 elicits cytoprotection via...
Cervical spinal cord injury (SCI) can dramatically impair diaphragm muscle function and often necessitates mechanical ventilation (MV) to maintain adequate pulmonary gas exchange. MV is a life-saving intervention. However, prolonged results in atrophy impaired of the diaphragm. Since cervical SCI also trigger atrophy, it may create preconditions that exacerbate ventilator-induced dysfunction (VIDD). Currently, no drug therapy or clinical standard care exists prevent minimize following SCI....
Mechanical ventilation is a life-saving intervention for patients in respiratory failure. Unfortunately, prolonged ventilator support results diaphragmatic atrophy and contractile dysfunction leading to diaphragm weakness, which predicted contribute problems weaning from the ventilator. While it established that ventilator-induced oxidative stress required development of signaling pathway(s) trigger oxidant production remain unknown. However, recent evidence reveals increased plasma levels...
Heat stress and hydration may both alter plasma volume (PV) responses during acute exercise; potential interactions have not been fully studied. The purpose of this study was to determine the effect graded elevations in skin temperature (Tsk) on PV changes steady-state exercise under conditions euhydration (EU) hypohydration (HYPO, -4% body mass). Thirty-two men (22 ± 4 yr) were divided into four cohorts (n = 8 each) completed EU HYPO trials one environment [ambient (Ta) 10, 20, 30, 40°C]....
Mechanical ventilation is a life-saving intervention for patients with respiratory failure. Unfortunately, major complication associated prolonged mechanical ventilator-induced diaphragmatic atrophy and contractile dysfunction, termed dysfunction (VIDD). Emerging evidence suggests that positive pressure (PPV) promotes lung damage (ventilator-induced injury [VILI]), resulting in the release of signaling molecules foster atrophic diaphragm resultant VIDD. Although recent report negative (NPV)...
The diaphragm is the most important inspiratory muscle in all mammals, and ventilatory insufficiency caused by dysfunction leading cause of morbidity mortality many genetic acquired diseases affecting skeletal muscle. Currently, pharmacological inhibitors, genetically modified animals, invasive procedures are used to study disorders diaphragm. However, these methodologies can be problematic because off-target drug effects possible nonphysiological consequences lifelong alterations....
Prolonged mechanical ventilation (MV) leads to rapid diaphragmatic atrophy and contractile dysfunction, which is collectively termed "ventilator-induced diaphragm dysfunction" (VIDD). Interestingly, endurance exercise training prior MV has been shown protect against VIDD. Further, recent evidence reveals that sedentary animals selectively bred possess a high aerobic capacity similar skeletal muscle phenotype muscles from trained animals. Therefore, we tested the hypothesis with intrinsic...
Oral rehydration solutions (ORS) are specifically formulated with an osmolality to optimize fluid absorption. However, it is unclear how many ORS products comply current World Health Organization (WHO) guidelines and the osmotic shelf-life stability not known. Therefore, purpose of this investigation was examine within between product variation in both pre-mixed reconstituted powders. Additionally, examined over time. The five different six powdered were measured. Pre-mixed stored at room...
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing therapeutic countermeasure protect against MV-induced atrophy important. due, at least part, increased production reactive oxygen species (ROS) mitochondria activation key proteases (i.e., calpain caspase-3). In this regard,...
Water planning is an important risk management concern for road race event organizers.To compare water and cup prediction outputs from a mobile application (app) tool against: 1) measured group sweat losses, 2) documented usage, 3) traditional mathematical solutions.Group mean sweating rates (L·h) 12 published outdoor running studies were each compared to composite averages using the Road Race Planner© (RRWP) app. Estimated (gallons) (number) needs also with usage at large marathon...