A5018791265- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Hedgehog Signaling Pathway Studies
- Immune cells in cancer
- Appendicitis Diagnosis and Management
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Inflammasome and immune disorders
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Diagnosis and treatment of tuberculosis
- Connective tissue disorders research
- Sarcoidosis and Beryllium Toxicity Research
- Abdominal Trauma and Injuries
- Planarian Biology and Electrostimulation
- Radiative Heat Transfer Studies
- Hemostasis and retained surgical items
- Liver Disease Diagnosis and Treatment
- COVID-19 Pandemic Impacts
- Geotechnical Engineering and Soil Mechanics
- Additive Manufacturing and 3D Printing Technologies
Ningbo University
2022-2025
Nanjing Medical University
2021-2022
Jiangsu Province Hospital
2021-2022
Shenzhen University
2022
Affiliated Hospital of Hangzhou Normal University
2018-2021
China Institute Of Communications
2021
Gannan Medical University
2020
First Affiliated Hospital of Gannan Medical University
2020
Weatherford College
2020
Chengdu Surveying Geotechnical Research Institute
2016
Three-dimensional (3D) bioprinting embedded within a microgel bath has emerged as promising strategy for creating intricate biomimetic scaffolds. However, it remains great challenge to construct tissue-scale structures with high resolution by using 3D due the large particle size and polydispersity of medium, well its limited cytocompatibility. To address these issues, novel uniform sub-microgels cell-friendly cationic-crosslinked kappa-carrageenan (κ-Car) are developed through an...
Articular cartilage tissue has limited self-repair capabilities, with damage frequently progressing to irreversible degeneration. Engineered tissues constructed through bioprinting and embedded stem cell aggregates offer promising therapeutic alternatives. Aggregates of bone marrow mesenchymal stromal cells (BMSCs) demonstrate enhanced more rapid chondrogenic differentiation than isolated cells, thus facilitating repair. However, it remains a key challenge precisely control biochemical...
Smooth muscles play a vital role in peristalsis, tissue constriction, and relaxation but lack adequate self-repair capability for addressing extensive muscle defects. Engineering scaffolds have been broadly proposed to repair the tissue. However, efforts date shown that those engineered focus on cell alignment 2-dimension (2D) fail direct cells align 3D area, which is irresolvable remodel architecture restore functions like contraction relaxation. Herein, we introduced an iron oxide (Fe 3 O...
Engineered scaffolds are used for repairing damaged esophagus to allow the precise alignment and movement of smooth muscle peristalsis. However, most these focus solely on inducing cell through directional apparatus, often overlooking promotion tissue formation causing reduced esophageal repair effectiveness. To address this issue, we first introduced aligned nano-ferroferric oxide (Fe3O4) assemblies a micropatterned poly(ethylene glycol) (PEG) hydrogel form micro-/nano-stripes. Further...
OPINION article Front. Public Health, 05 June 2020Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 8 - 2020 | https://doi.org/10.3389/fpubh.2020.00265
Increasing evidence has suggested an association between the expression profiles of microRNAs (miRs) and gallbladder cancer (GBC). Recently, miR‑182 been demonstrated to exert tumor‑promoting effects. However, biological activity molecular mechanisms in GBC remain unclear. The results present study that was significantly upregulated tissues cell lines (GBC‑SD SGC‑996). In addition, miR‑182‑knockdown attenuated epithelial‑mesenchymal transition (EMT) cells, as indicated by decreased migratory...
Metformin, a traditional first-line pharmacological treatment for type 2 diabetes, has recently been shown to have anti-cancer effects on hepatocellular carcinoma (HCC). However, the molecular mechanism underlying anti-tumor activity of metformin remains unclear. The Sonic hedgehog (Shh) signaling pathway is closely associated with initiation and progression HCC. Therefore, aim current study was investigate biological behavior HCC functional in Shh pathway. induced HepG2 cells using...
Embedded three-dimensional (3D) bioprinting utilizing a granular hydrogel supporting bath has emerged as critical technique for creating biomimetic scaffolds. However, engineering suitable gel suspension medium that balances precise bioink deposition with cell viability and function presents multiple challenges, particularly in achieving the desired viscoelastic properties. Here, novel κ-carrageenan is fabricated through an easy-to-operate mechanical grinding process, producing homogeneous...
Background/Aims: To investigate the effect and possible mechanism of lanthanum citrate on proliferation apoptosis human hepatocellular carcinoma (HCC) cell line SMMC-7721 through Hedgehog (Hh) signaling pathway.Materials Methods: Different concentrations KAAD-cyclopamine (the Hh pathway representative inhibitor) were used to treat cells.Cell was detected using Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assays.Cell flow cytometry analysis Annexin V-FITC/ propidium iodide (PI).The...
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) a key component and functions as reliable marker Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in progression various types cancer, including HCC. However, its effect on HCC invasion metastasis underlying mechanism remain to be elucidated. Small interference RNA was employed silence gene...
A 33-year-old female with a mild elevation of liver transaminase was sent to the general surgery department for medical services due upper-right abdominal pain 2 weeks. liquid dark area ~4 × 3 cm in size theoretical location pancreatic segment common bile duct detected by CT no enhancement cystic wall found enhanced scan. The patient then diagnosed choledochal cyst based on results radiological images preoperatively. During operation, isolated dilatation middle part duct, and its caudal...
Introduction: As one of the short-term complications after inguinal hernia repair, mesh infection frequently occurs but rarely leads to ileocutaneous fistula. We present a rare case fistula 8 years plug repair with polypropylene mesh. Case Presentation: The patient was 67-year-old male who underwent right hernia. Eight primary skin ulceration pus presented in groin area, and final diagnosis enterocutaneous According laparoscopic exploration, ileum below closely adhered abdominal wall. After...