A5049529007- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- interferon and immune responses
- Virus-based gene therapy research
- DNA Repair Mechanisms
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Tourism, Volunteerism, and Development
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- thermodynamics and calorimetric analyses
Goethe University Frankfurt
2021-2025
National Institute of Cholera and Enteric Diseases
2015-2023
Abstract SUMOylation is a post-translational modification of proteins that regulates these proteins’ localization, turnover or function. Aberrant frequently found in cancers but its origin remains elusive. Using genome-wide transposon mutagenesis screen MYC-driven B-cell lymphoma model, we here identify the SUMO isopeptidase (or deconjugase) SENP6 as tumor suppressor links unrestricted to development and progression. Notably, recurrently deleted human lymphomas deficiency results...
Proteasome inhibition is a highly effective treatment for multiple myeloma (MM). However, virtually all patients develop proteasome inhibitor resistance, which associated with poor prognosis. Hyperactive small ubiquitin-like modifier (SUMO) signaling involved in both cancer pathogenesis and progression. A state of increased SUMOylation has been aggressive biology. We found that relapsed/refractory MM characterized by SUMO-high state, high expression the SUMO E1-activating enzyme (SAE1/UBA2)...
Phosphoproteomics-based platforms have been widely used to identify post translational dynamics of cellular proteins in response viral infection. The present study was undertaken assess differential tyrosine phosphorylation during early hours rotavirus (RV) SA11 Heat shock (Hsp60) were found be enriched the data set RV-SA11 induced differentially tyrosine-phosphorylated at 2 hr infection (hpi). Hsp60 further phosphorylated by an activated form Src kinase on 227th residue, and mitochondrial...
Abstract The established role of cytosolic and nuclear inclusions TDP-43 in the pathogenesis neurodegenerative disorders has multiplied efforts to understand mechanisms that control aggregation spurred searches for approaches limiting this process. Formation clearance aggregates are controlled by an intricate interplay cellular proteostasis systems involve post-translational modifications frequently rely on spatial control. We demonstrate attachment ubiquitin-like SUMO2 modifier...
Dynamic equilibrium between mitochondrial fission and fusion serves as an important quality control system within cells ensuring cellular vitality homeostasis. Viruses often target dynamics a part of their obligatory reprogramming. The present study was undertaken to assess the status regulation during rotavirus infection. Distinct fragmentation syncytia observed late hours RV (SA11, Wa, A5-13) nonstructural protein 4 (NSP4) identified viral trigger for disrupted morphology. Severance...
Abstract Rotavirus (RV), the major etiological agent of viral gastroenteritis in young children, kills over 200 thousand infants each year. In spite available vaccines, rotaviral diarrhoea is still a problem developing countries Asia and Africa. Therefore, studies on RV infection host antiviral responses are warranted. The active correlation between virus activation autophagy machinery positive influence replication have been documented recently. Previous study from our group showed...
Surveillance for maintaining genomic pristineness, a protective safeguard of great onco-preventive significance, has been dedicated in eukaryotic cells to highly conserved and synchronised signalling cascade called DNA damage response (DDR). Not surprisingly, foreign genetic elements like those viruses are often potential targets DDR. Viruses have evolved novel ways subvert this genome vigilance by twisting canonical DDR skewed, noncanonical through selective hijacking some components while...
Reprogramming the host cellular environment is an obligatory facet of viral pathogens to foster their replication and perpetuation. One such reprogramming events dynamic cross-talk between viruses death signaling pathways. Rotaviruses (RVs) have been reported develop multiple mechanisms induce apoptotic programmed cell for maximizing spread pathogenicity. However, importance non-apoptotic has remained elusive in context RV infection. Here, we report that RV-induced apoptosis accompanies...
Eukaryotic cells adopt highly tuned stress response physiology under threats of exogenous stressors including viruses to maintain cellular homeostasis. Not surprisingly, avoidance pathways is an essential facet virus-induced obligatory host reprogramming invoke a environment conducive viral perpetuation. Adaptive responses oxidative and electrophilic are usually taken care by antioxidant defense system, core which lies the redox-responsive transcription factor nuclear erythroid 2-related 2...
RNA interference (RNAi) is an evolutionary ancient innate immune response in plants, nematodes, and arthropods providing natural protection against viral infection. Viruses have also gained counter-defensive measures by producing virulence determinants called viral-suppressors-of-RNAi (VSRs). Interestingly, spite of dominance interferon-based immunity over RNAi somatic cells higher vertebrates, recent reports are accumulating favour retention the antiviral nature mammalian cells. The present...