A5001178077- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Skin Protection and Aging
- Vitamin D Research Studies
- Cancer Genomics and Diagnostics
- Nail Diseases and Treatments
- Cell Image Analysis Techniques
- melanin and skin pigmentation
- AI in cancer detection
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
- Optical Coherence Tomography Applications
- Ear and Head Tumors
- Testicular diseases and treatments
- Reconstructive Facial Surgery Techniques
- Cancer Diagnosis and Treatment
- Dermatologic Treatments and Research
- Soft tissue tumor case studies
Fundación Instituto Valenciano de Oncología
2019-2025
Valencia Catholic University Saint Vincent Martyr
2019-2023
Universitat de València
2019
University Dermatology
2019
Universidad de Valladolid
2017
La Jolla Alcohol Research
2017
Hospital Madre Teresa
2017
Hospital Clínico Universitario de Valladolid
2017
<h3>Importance</h3> The lymphatic and the hematogenous pathways have been proposed for disease progression in cutaneous melanoma, but association with recurrence has not studied separately to date. <h3>Objective</h3> To identify risk factors associated metastasis. <h3>Design, Setting, Participants</h3> This retrospective cohort study included 1177 patients malignant melanoma treated at Instituto Valenciano de Oncología, València, Spain. Data were retrieved from database January 1, 2000,...
The aim of this study is to evaluate the relation between 25-hydroxyvitamin D levels at diagnosis and pathological characteristics in primary invasive melanoma. A cross-sectional was designed based on a series 204 consecutive patients diagnosed melanomas 2013-2017 period single institution. serum were assessed, three groups defined by vitamin status: deficiency, insufficiency, sufficiency. Clinical compared Chi-square test. Logistic regression models performed association status Breslow...
Biosynthetic porcine type I collagen dressing is useful to close ulcers and secondary intention healing of surgical cancer wounds. To identify factors associated with the time such We conducted a retrospective observational study patients on oncological dermatological surgery in center. Healing was studied based age, sex, personal history comorbidities, usual medication, anatomical location, performed size defect. Statistical analysis using ANOVA test logistic regression. A total 306 were...
Lentigo maligna (LM) presents an invasive component in up to 20% of biopsied cases, but date the histologic features useful detecting this have not been described. Some characteristics are hypothesized contribute progression LM invasion.To identify associated with lentigo melanoma (LMM) patients diagnosed by a partial diagnostic biopsy.A retrospective cross-sectional study treated between January 1, 2000, and December 31, 2017, was conducted referral oncology center València, Spain. Data...
Survival predictions are currently determined on the basis of NRAS/BRAF mutations, even though TERT promoter mutations have been recently associated with a poor prognosis in stage I-II melanomas. Usually, it is not recommended to perform mutational test primary melanoma, as results do always reflect status metastases. In particular, trunk melanomas reported an unfavourable prognosis. A series 105 advanced melanoma patients were analysed by Sanger sequencing. Univariate/multivariate binary...
The distinct somatic mutations that define clinical and histopathological heterogeneity in cutaneous melanoma could be dependent on host susceptibility to exogenous factors like ultraviolet radiation. Firstly, characterize patients with clinically pathologically based the mutational status of BRAF, NRAS TERT promoter. Secondly, elucidate modified features due presence promoter over background either BRAF or mutations. We performed a retrospective study 563 by investigating observed...
Some studies have suggested a relationship between type 2 diabetes mellitus (T2DM) and increased incidence of melanoma. Efforts are under way to identify preventable treatable factors associated with greater melanoma aggressiveness, but no date examined the T2DM aggressiveness cutaneous at diagnosis.To explore potential associations T2DM, glycaemic control metformin treatment melanoma.We conducted cross-sectional multicentric study in 443 patients diagnosed At diagnosis, all completed...
Introduction: Since the field of dermatopathology is not an exact science, it prone to personal subjectivity, which sometimes causes disagreements on diagnosis and assessment some histological features. In case melanoma, variables such as regression are associated with low interobserver agreement. On contrary, other measurement Breslow thickness show high reproducibility. Objective: The main objective our study was investigate multiple features 60 consecutive cases melanoma establish Methods...
A great portion of cutaneous melanoma’s diagnoses nowadays is attributed to thin tumors with up 1 mm in Breslow thickness (hereafter CMs), which occasionally metastasize. The objective this study was identify CM’s metastatic patterns from a topographical and chronological standpoint. total 204 cases CMs five specialized centers were included the study, corresponding data collected (clinical, epidemiological, histopathological information primary tumor number, anatomical site, time intervals...
Vitamin D plays a fundamental role in many metabolic pathways, including those involved cell proliferation and the immune response. Serum levels of this vitamin have been linked to melanoma risk prognosis. This study aimed assess prognostic value serum level melanoma.Retrospective, observational, longitudinal, analytical 286 patients with histologic diagnosis whom were measured at time diagnosis. We analyzed associations between epidemiologic clinical variables pathology findings; we also...
9572 Background: For pts with resected CM, adjuvant anti-PD1 is approved for AJCC v8 stage IIB–IV and BRAFi/MEKi III–IV disease. Nonetheless, there remains a subgroup of within stages IB/IIA, which at high risk relapse death, accounts considerable share overall CM mortality (1), lacks access to such therapy. Thus, clinical trials in this “early”-stage setting may be merited. However, not detectable via staging alone. A prognostic 7-IHC assay that was developed (2), analytically (3)...
According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with propensity melanocyte proliferation and another one associated cumulative solar damage (CSD). While characterized clinically epidemiologically, differences in molecular profiles between groups have remained primarily uninvestigated. This study has used custom gene panel bioinformatics tools investigate potential thoroughly cohort of 119 patients belonging CSD groups. We found that melanomas had...
The study of subungual melanocytic lesions can present challenges because the clinical and histologic characteristics nail unit difficulty performing biopsies processing specimens. These be even more challenging in children due to differences epidemiological profiles between adult pediatric populations. Many features that would raise alarm an do not have same implications children. Consensus is also lacking on when a biopsy needed rule out malignancy setting. In view these considerations...
<b><i>Background:</i></b> The incidence of cutaneous melanoma, an important global public health problem, has been increasing over the last several decades. <b><i>Objectives:</i></b> In order to decrease melanoma-related mortality, ways communicate and implement correct methods for conducting primary secondary prevention measures (such as early detection via self-examination) should be investigated. <b><i>Materials...
Vitamin D deficiency associates with the risk of developing many diseases, including cancer. At molecular level, vitamin appears to have an antineoplastic effect. However, role in cancer pathogenesis remains unelucidated and numerous studies resulted discordant results. This study aimed determine whether during melanoma diagnosis increases non-cutaneous second primary cancers (SPC).
The large-scale implementation of primary and secondary skin cancer prevention strategies in recent decades has led to an increase the diagnosis thin melanomas a decrease mean thickness tumours diagnosed. number newly diagnosed thick melanomas, however, remained stable. To investigate associations between melanoma thickness, clinical presentation demographic phenotypic characteristics. study is based on cross-sectional 1,459 patients with from dermatology department at tertiary hospital...
Acral location of melanomas is associated with poor survival. It can be due, at least in part, to the fact that acral lentiginous melanoma, a distinct melanoma subtype, has particular biological profile and bad clinical behavior. However, since almost 50% are not worse behavior could also attributable intrinsic characteristics location.This study aimed investigate if lower limb excluding differ by retrospective, observational recruited patients from an oncology referral center Spain. We...
Background: Sentinel lymph node (SLN) status is recognized as the most important prognostic factor for patients with cutaneous melanoma. However, sometimes it not possible to identify SLN. The phenomenon of non-identification SLN and its role have been thoroughly evaluated in melanoma literature. objective this study was which patient or tumor variables may be associated evaluate Methods: Observational retrospective 834 who underwent biopsy at Instituto Valenciano de Oncología. Results:...