A5040643086- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Vector-borne infectious diseases
- Syphilis Diagnosis and Treatment
- Synthesis and Biological Evaluation
- Lysosomal Storage Disorders Research
- Viral Infections and Vectors
- Malaria Research and Control
- Biochemical and Molecular Research
- Sex work and related issues
- Bioactive Compounds and Antitumor Agents
- Coffee research and impacts
- Leptospirosis research and findings
- T-cell and B-cell Immunology
- Pain Mechanisms and Treatments
- Immune responses and vaccinations
- Cardiomyopathy and Myosin Studies
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Dermatological diseases and infestations
- Virology and Viral Diseases
- GABA and Rice Research
- Complement system in diseases
- Acupuncture Treatment Research Studies
- Vagus Nerve Stimulation Research
Rutgers, The State University of New Jersey
2020-2024
Rutgers New Jersey Medical School
2020-2024
Universidade de São Paulo
2011-2019
Laboratoire de Biochimie
2019
Clearing blood-stage malaria parasites without inducing major host pathology requires a finely tuned balance between pro- and anti-inflammatory responses. The interplay regulatory T (Treg) cells dendritic (DCs) is one of the key determinants this balance. Although experimental models have revealed various patterns Treg cell expansion, DC maturation, cytokine production according to infecting parasite species, no studies compared all these parameters in human infections with Plasmodium...
The inhibition of some glutamate metabolic pathways could lead to diminished parasite survival. In this study, the effects L-methionine sulfoximine (MS), DL-methionine sulfone (MSO), and sulfoxide (MSE), three analogs, on several biological processes were evaluated. We found that these analogs inhibited growth epimastigotes cells showed a synergistic effect with stress conditions such as temperature, nutritional starvation, oxidative stress. specific activity for reductive amination...
To develop an alcohol-free solution suitable for children of benznidazole, the drug choice treatment Chagas disease.In a quality-by-design approach, systematic optimisation procedure was carried out to estimate values factors leading maximum concentration. The formulations were analysed in terms chemical and physical stability content. final preparation subjected vivo palatability assay. Mice infected treated orally murine model.The results showed that benznidazole solubility increased up...
Syphilis is a global, re-emerging sexually transmitted infection and congenital syphilis remains major cause of adverse pregnancy outcomes due to bacterial in developing nations with high rate fetus loss. The molecular mechanisms involved pathogenesis the causative agent, Treponema pallidum subsp. remain poorly understood difficulties working this pathogen, including inability grow it pure culture. To reduce spread syphilis, we must first increase our knowledge virulence factors T. their...
Lyme disease is caused by Borrelia burgdorferi, and the pathogenesis of complex with both bacterial host factors contributing to inflammatory responses. affects different organs including joints results in arthritis. Immune responses stimulated B. burgdorferi through toll-like receptors cause infiltration leukocytes, which produce cytokines facilitate spirochete clearance. However, arthritic manifestations chronic fatigue syndrome-like symptoms persist long after completion antibiotic...
Toll-like receptors (TLRs) are a class of membrane-spanning proteins host cells. TLR2 and TLR4 displayed on the surface macrophages, neutrophils dendritic cells recognise structurally conserved microbial signatures defined as Pathogen associated molecular patterns (PAMPs). C3H mice susceptible to tick-borne pathogens; Lyme disease causing Borrelia burgdorferi that manifests arthritis carditis Apicomplexan protozoan, Babesia microti (Bm) causes significant parasitemia with erythrocytopenia...
Objective: Objective of this study was to explore factors and outcomes associated with gestational syphilis in Peru.Methods: Women from the miscarriage, vaginal delivery, C-section wards a large maternity hospital Lima with, or without diagnosis were enrolled their pregnancy compared. Maternal status using maternal blood child serostatus cord determined by rapid plasma reagin (RPR) tests (RST). Newborns' clinical records used determine congenital syphilis.Results: Among 340 women samples,...
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease that affects 5–6 million people in endemic areas of the Americas. Presently, chemotherapy relies on two compounds were proposed as trypanocidal drugs four decades ago: nifurtimox and benznidazole. Both are able to eliminate parasitemia avoid seroconversion infected when used acute phase; however, their use chronic phase (the time majority cases diagnosed) limited due serious side effects. Memantine glutamate...
Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, oxidative stress. On this basis, we investigated possible relationship between prolinemia severity T. cruzi infection in chronic patients, reported here. The study population consisted 112 subjects, separated into 83 chronically cruzi-infected patients 29 age-matched healthy...
Transplacental transmission of syphilis causing spirochete, Treponema pallidum subspecies pallidum, from mother to child results in congenital syphilis, an ever-expanding devastating disease worldwide. Although adverse effects untreated gestational Lyme disease, caused by a related Borrelia burgdorferi on fetus viability and development have been observed, cases are not reported. In this study, we show that B. colonizes mammary glands C3H mice only postpartum; however, neither these...
Abstract Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease that affects 5-6 million people in endemic areas of the Americas. Presently, chemotherapy relies on two compounds were proposed as trypanocidal drugs four decades ago: nifurtimox and benznidazole. Both are able to eliminate parasitemia avoid seroconversion infected when used acute phase; however, their use chronic phase (the time majority cases diagnosed) limited due serious side effects. Memantine...