A5021447976- Sepsis Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Clusterin in disease pathology
University of British Columbia
2023-2025
St. Paul's Hospital
2023-2025
Cincinnati Children's Hospital Medical Center
2023
Lipoproteins and their component apolipoproteins play an important role in sepsis. However, little is known with regard to the association causal contribution of these proteins mortality patients different ancestries following septic shock. The objective this study was determine whether lipoprotein apolipoprotein levels, related genetic variants, are associated clinical outcomes We investigated between levels at point admission intensive care unit in-hospital 687 Japan diagnosed For each...
Abstract Background Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance, holds promise as a potential therapeutic approach among adults. In contrast, we have previously demonstrated higher mortality in the juvenile host. Given pleiotropic effects of on endothelium, canonical serum lipoproteins, both which...
Abstract Background: Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) inhibition has shown therapeutic promise, likely through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance. contrast, we previously demonstrated higher mortality in septic juvenile hosts LOF. addition to direct influence on serum levels, exerts pleiotropic effects...