A5065094998- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Computational Drug Discovery Methods
University of Bradford
2020-2022
Imperial College London
2020-2021
Chemical probes that covalently modify cysteine residues in a protein-specific manner are valuable tools for biological investigations. Covalent fragments increasingly implemented as probe starting points, but the complex relationship between fragment structure and binding kinetics makes covalent optimization uniquely challenging. We describe new technique discovery enables data-driven of potency selectivity. This platform extends beyond existing repertoire methods identifying hits by...
Abstract Inactivating mutations including both germline and somatic in the adenomatous polyposis coli (APC) gene drives most familial sporadic colorectal cancers. Understanding metabolic implications of this mutation will aid to establish its wider impact on cellular behaviour potentially inform clinical decisions. However, date, alterations lipid metabolism induced by APC remain unclear. Intestinal organoids have gained widespread popularity studying cancer chemotherapies, because their 3D...
Abstract Duocarmycins are natural DNA alkylators which have potent toxicity with no established mechanism of resistance. Prodrug versions need to be developed ensure a sufficient therapeutic window for cancer treatment (1). A series duocarmycin bioprecursors been in-house lack key hydroxyl trigger group, required spirocyclisation and subsequent activation. This group can regioselectivity restored by specific Cytochrome P450 enzymes (CYPs), primary focus on associated isoforms CYP1A1 CYP2W1...