A5100661925- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asthma and respiratory diseases
- Crystal Structures and Properties
- Antimicrobial Peptides and Activities
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Solid-state spectroscopy and crystallography
- Lymphoma Diagnosis and Treatment
- Polyoxometalates: Synthesis and Applications
- Biochemical and Structural Characterization
- Air Quality and Health Impacts
- Asian Culture and Media Studies
- Freshwater macroinvertebrate diversity and ecology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Blood properties and coagulation
- Food Quality and Safety Studies
- Marine Sponges and Natural Products
- Chronic Lymphocytic Leukemia Research
- Dermatology and Skin Diseases
- Phytochemistry and Biological Activities
- Head and Neck Surgical Oncology
- Species Distribution and Climate Change
Soonchunhyang University
2020-2025
Bucheon University
2020-2025
Sungkyunkwan University
2006-2023
Samsung (South Korea)
2020-2023
Chosun University
2017-2022
Sahmyook University
2018-2022
Seoul Women's University
2022
Seoul Institute
2021
Wonkwang University
2021
Korea Institute of Nuclear Safety
2019
Abstract Transdermal drug delivery patches based on hydrogels are widely used for the transdermal of diverse drugs. However, most do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive consisting polyacrylamide/polydopamine (PAM/PDA) embedded with extra‐large pore mesoporous silica nanoparticles (XL‐MSNs) proposed synergy cohesive and properties. The incorporation XL‐MSNs leads enhanced strength due an increased property derived from molecular interactions between...
Atopic dermatitis (AD) is a chronic inflammatory disease associated with unbalanced immune responses in skin tissue. Although steroid drugs and antihistamines are generally used to treat AD, continuous administration causes multiple side effects. High oxidative stress derived from reactive oxygen species (ROS) has been implicated the pathogenesis of AD. A high level ROS promotes release pro-inflammatory cytokines T-cell differentiation, resulting onset deterioration Here, we report...
Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent inflammatory immune response often accompanied excessive reactive oxygen species (ROS) production. For effective IBD treatment, there a high demand for safe targeted therapy that can be orally administered. In this study, we aimed to propose the use of inflamed colon-targeted antioxidant nanotherapeutics (ICANs) in situ oxidative stress level modulation colitis. ICANs consist mesoporous silica nanoparticles...
A new noncentrosymmetric polar ternary tellurium(IV) oxide phosphate, Te(2)O(PO(4))(2), has been synthesized by a standard solid-state reaction, and the structure was determined single crystal X-ray diffraction. The material shows three-dimensional framework that is composed of slightly distorted TeO(5) square pyramids PO(4) tetrahedra. Within three-, four-, seven-membered ring channels are observed along [100] direction. In addition to structural characterization, second-harmonic generation...
BACKGROUNDThe aim of study was to determine the relative frequency malignant lymphoma according World Health Organization (WHO) classification in Korea.METHODSA total 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site involvement immunophenotypes obtained.RESULTSThe non-Hodgkin (NHL) Hodgkin (HL) 95.4% 4.6%, respectively. B-cell lymphomas accounted for 77.6% all NHL, while T/natural killer (T/NK)-cell...
Rates of microbial drug resistance are increasing worldwide; therefore, antimicrobial peptides (AMPs) considered promising alternative therapeutic agents to antibiotics. AMPs essential components the innate immune system and exhibit broad-spectrum activity. P5 is a Cecropin A-Magainin 2 hybrid analog peptide with activity against Gram-negative Gram-positive bacteria. In present study, truncated were designed reduction length, retainment their low toxicity at high concentrations compared that...
We developed an antimicrobial peptide (AMP) as a candidate substance for replacing antibiotics. Previously, novel 18-amino acid Hylin a1 was isolated from electro-stimulated arboreal South American frog Hypsiboas albopunctatus, and found to demonstrate activity cytotoxicity. In recent study, the analog peptides were designed based on parent decrease toxicity maintain efficacy. The substituted with alanine lysine, resulting in formation of amphipathic α-helical structures membrane-mimicking...
Hp1404, identified from the venom of scorpion Heterometrus petersii, displays antimicrobial activity with cytotoxicity. Several synthetic peptides were designed based on parent peptide Hp1404 to reduce cytotoxicity and improve (deletion glycine phenylalanine, substitution leucine lysine). The analogue generated comprised 12 amino acids displayed amphipathic α-helical structures, higher hydrophobic moments net positive charge than those Hp1404. analogues showed less hemolytic toxic effects...
New 3-amino-5-ethenylcyclopentenones, myrothenones A (4) and B (5), were isolated together with known 6-n-pentyl-α-pyrone (1), trichodenone (2), cyclonerodiol (3) from the marine algicolous fungus of genus Myrothecium. The structure absolute stereochemistry new compounds established by spectral interpretation X-ray analysis. Compounds 1 4 exhibited a tyrosinase inhibitory activity IC50 value 0.8 6.6 μM, respectively, which are more active than kojic acid (IC50, 7.7 μM) currently being used...
Acute exacerbation of asthma is often characterized by increased mucus production and hypersecretion. While mucins are believed to play a role in the pathogenesis pathophysiology airway diseases, no genetic studies on mucin genes have been conducted date. We initially analyzed genome-wide association dataset 608 asthmatics, focusing gene polymorphisms. Subsequently, we fine genotyping MUC13 separate cohort 704 bronchial patients monitored for over year. Using generalized linear models...
Two new metal antimony oxychlorides, Sb(2)ZnO(3)Cl(2) and Sb(16)Cd(8)O(25)Cl(14), have been synthesized by solid-state reactions using Sb(2)O(3) ZnCl(2) (or CdCl(2)) as reagents. The structures of Sb(16)Cd(8)O(25)Cl(14) determined single-crystal X-ray diffraction. Both the reported materials contain Sb(3+) cations that are in an asymmetric coordination environment attributable to their stereoactive lone pair. has a novel two-dimensional layered structure consisting distorted ZnO(2)Cl(2)...
The abuse of antibiotics for disease treatment has led to the emergence multidrug resistant bacteria. Antimicrobial peptides, found naturally in various organisms, have received increasing interest as alternatives conventional because their broad spectrum antimicrobial activity and low cytotoxicity. In a previous report, Macropin, isolated from bee venom, exhibited against both gram-positive negative present study, Macropin was synthesized its antibacterial anti-biofilm activities were...
An amphipathic α-helical peptide, Hp1404, was isolated from the venomous gland of scorpion Heterometrus petersii. Hp1404 exhibits antimicrobial activity against methicillin-resistant Staphylococcus aureus but is cytotoxic. In this study, we designed peptides by substituting amino acids at 14 C-terminal residues to reduce toxicity and improve antibacterial activity. The analog peptides, which had an structure, were active gram-positive gram-negative bacteria, particularly multidrug-resistant...
Two new tubular alkali metal–organic framework materials, A3[C6H3(CO2)(CO2H0.5)(CO2H)]2 (A = K or Rb) have been synthesized through solvothermal reactions using NH4F, 1,3,5-C6H3(CO2H)3, ANO3, and N,N-Dimethylformamide at 180 °C. Single-crystal X-ray diffraction was used to determine the structures of reported materials. novel consisting channels AO6 AO8 metal oxide groups as well benzenetricarboxylate organic linker. Detailed structural analyses with full characterization including infrared...
A new layered bismuth tellurium oxychloride, Bi3Te4O10Cl5 has been synthesized by a solid-state reaction under vacuum using Bi2O3, TeO2, and TeCl4 as reagents. The structure of determined single-crystal X-ray diffraction. contains two different lone pair cations, Bi3+ Te4+ that are in asymmetric coordination environments. novel two-dimensional consisting distorted BiO4Cl2 octahedra, BiO4Cl3 polyhedra, TeO4 isolated Cl− ions. Complete structural analysis, infrared spectrum, thermogravimetric...
Unprecedented 1-D helical calcium−organic framework material, Ca[NC5H3(CO2)2](H2O)1.5, has been synthesized for the first time under hydrothermal reaction conditions using Ca(OH)2, 2,6-NC5H3(CO2H)2, (CH3)2NCOH, HNO3, and H2O as reagents. A complete characterization including transformation of chain with pincers to another helix steps by water is reported.
Injection of injured rabbit vocal folds with human adipose-derived stem cells (hADSCs) led to improved wound healing and fewer signs scarring as demonstrated by a decreased collagen content in the treated compared untreated folds. hADSCs remained viable for up 12 weeks folds.The aim this study was investigate morphologic histologic properties scarred following injection hADSCs.This randomized, controlled animal study. Twenty-four from New Zealand rabbits were using CO(2) laser injected...