A5068535317- Sperm and Testicular Function
- Hormonal and reproductive studies
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Sexual function and dysfunction studies
- Medicinal Plants and Neuroprotection
- Biochemical effects in animals
- Glioma Diagnosis and Treatment
- Birth, Development, and Health
- African Botany and Ecology Studies
- Nigella sativa pharmacological applications
- Innovations in Medical Education
- Neuroscience and Neuropharmacology Research
- Anatomy and Medical Technology
- Ovarian function and disorders
- Phytochemistry and Biological Activities
- Urinary Bladder and Prostate Research
- Tryptophan and brain disorders
- HIV Research and Treatment
- Drug-Induced Ocular Toxicity
- Plant Toxicity and Pharmacological Properties
- Reproductive System and Pregnancy
- Moringa oleifera research and applications
- Neurotransmitter Receptor Influence on Behavior
- Phytoestrogen effects and research
Kampala International University
1970-2024
University of the Witwatersrand
2020-2023
Alcohol consumption alongside combination antiretroviral therapy (cART) has attracted research interest, especially because of increasing male infertility.This study investigated the combined effects alcohol and cART on testicular morphology, biomarkers oxidative stress, inflammation, apoptosis.Rats, weighing 330-370 g, were divided into four groups six animals each; control, treated (A), cART, plus (A+cART).Following 90 days treatment period, euthanized, testis extracted, routinely...
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complications via induction of oxidative stress inflammation. Moreover, these are the most common factors implicated in male reproductive dysfunctions. This study evaluated testicular stress, inflammation, apoptosis, germ cell proliferation diabetic rats receiving or cART their combination. Thirty adult Sprague Dawley were divided into five groups, each consisting six rats;...
Cadaveric dissection has remained an integral part of anatomical education globally; hence, the profiles cadavers, their gross tissue and microbial integrity great implication in education. This study determined profiles, cadavers used South-western Uganda (SWU) medical schools. A cross-sectional was carried out for three months anatomy microbiology laboratories SWU teaching institutions. Ethical approval obtained, were proportionately selected examined grossly, surface swabs taken analysis....
The prevalence of diabetic patients who abuse alcohol while on combination antiretroviral drug therapy (cART) is rising in society. Little known about the impact this scenario testes and male reproductive viability, therefore, these factors were evaluated. Thirty 10-week-old Sprague Dawley rats distributed into five groups six each: control, only (DM), treated with (DM+A), Atripla, fixed-dose cART (DM+cART), both (DM+A+cART). After 90 days treatment, terminated, blood harvested for...
Cleome gynandra is a medicinal plant that used all over Uganda to hasten childbirth because, it possesses the ability contract uterus. It also as an abortifacient in first trimester. In this study, effects of were investigated on estrous cycle and histology ovary uterus adult Wistar rat. Twelve female rats 130-140g average weight used. These divided into three groups four animals each. Group A received distilled water only, while B C 250mg/kg body 500mg/kg extract, orally daily respectively....
Khat is a psychoactive herbal drug of pronounced ethno-pharmacological significance often abused due to its unregulated use. It affects many brain centers including the prefrontal cortex which anterior most part frontal lobe. The modulates working memory, planning complex cognitive behaviors however; it linked psychological disorders such as depression, schizophrenia and memory loss. We studied effects exerted by khat on PFC cytoarchitecture functions since this highly interconnected with...
Ethambutol is an anti-tuberculosis drug important in treatment of multidrug resistant tuberculosis which on a rise due to emergence Human Immunodeficiency Virus. However, it has been associated with side effects optic nerve histology leading severe neuropathy. The purpose this study was establish the protective potential Lantana trifolium ethanolic extract against ethambutol induced histological changes nerve. Twenty five male adult wistar rats 110-130g average weight were used. These...
Objectives Calcium deregulation in diabetes mellitus (DM) is central to the brain-heart axis pathology. This has led use of medical plants complementary medicine such as Amaranthus hypochondriacus (GA). The objective study was establish effects grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels diabetic male Wistar rats. Methods involved six groups (n=5) with DM being induced 20 To rats, Group I received mixtard®, II positive control, Groups III IV GA at 25...
The prevalence of alcohol abuse and HIV/AIDS is high in males reproductive age; unfortunately, a incidence intake has been reported patients including those on combination antiretroviral therapy (cART). Incidentally, cART use have each implicated male dysfunction. Therefore, the interactive effects hormone levels, testicular connective tissue, androgen receptor Ki-67 expression were evaluated HIV naïve adult Sprague Dawley rats. Adult rats divided into four groups: control, (A), cART,...
Ethambutol is one of the first line drugs for treating tuberculosis. Its toxic effects on optic nerve are majorly classified as reversible. However, worsening vision and permanent loss after ethambutol discontinuation also documented. To determine effect toxicity oligodendrocytes at different periods treatment. Twenty-five male adult wistar rats 110-130g average weight were housed in cages, exposed to 12-hour dark light cycles. After week acclimatization, five animals randomly selected...