A5084039100- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Advanced Neuroimaging Techniques and Applications
- Virus-based gene therapy research
- Cardiac Imaging and Diagnostics
- Advanced X-ray Imaging Techniques
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Anatomy and Medical Technology
- Cancer Research and Treatments
- Systemic Sclerosis and Related Diseases
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Surgical Simulation and Training
- Organ Transplantation Techniques and Outcomes
- NMR spectroscopy and applications
- Nuclear Physics and Applications
- Connective tissue disorders research
National Institutes of Health Clinical Center
2024-2025
Technical University of Munich
2020-2024
Yale University
2020-2024
Vivantes Klinikum
2024
Klinikum rechts der Isar
2020-2023
Humboldt-Universität zu Berlin
2020-2022
Freie Universität Berlin
2020-2022
Charité - Universitätsmedizin Berlin
2020-2022
Background Patients with intermediate- and advanced-stage hepatocellular carcinoma (HCC) represent a highly heterogeneous patient collective substantial differences in overall survival. Purpose To evaluate enhancing tumor volume (ETV) burden (ETB) as new criteria within the Barcelona Clinic Liver Cancer (BCLC) staging system for optimized allocation of patients HCC to undergo transarterial chemoembolization (TACE). Materials Methods In this retrospective study, 682 who underwent conventional...
To determine whether the difference between MRI-based and ultrasound (US)-based volume measurements are associated with MRI/US-targeted fusion-guided biopsy outcomes. This retrospective, single-center study involved 4177 consecutive patients biopsied 2010 2023 using both fusion systematic biopsy. Biopsies were indicated because of elevated PSA levels or abnormal multiparametric MRI results. US calculated triplane ellipsoid formula, volumes obtained by semiautomatic planimetric segmentation....
Abstract Purpose This study aimed to describe the workflow and evaluate accuracy of a novel smartphone augmented reality (AR) application that includes an integrated needle guide, in phantom. Materials Methods A cover with guide was designed 3D-printed. An AR for percutaneous developed, which projected path based on rigid guide. After planning using this tool, operator could place through reach target. Six lesions out-of-plane entry points were targeted abdominal Timing placements measured...
<title>Abstract</title> Liver cancer ranks as the fifth leading cause of cancer-related death globally. Direct intratumoral injections anti-cancer therapeutics may improve therapeutic efficacy and mitigate adverse effects compared to intravenous injections. Some challenges are that liquid drug formulation not remain localized have unpredictable volumetric distribution. Thus, delivery varies widely, highly-dependent upon technique. An x-ray imageable poloxamer 407 (POL)-based gel was...
Abstract Purpose Targeting accuracy determines outcomes for percutaneous needle interventions. Augmented reality (AR) in IR may improve procedural guidance and facilitate access to complex locations. This study aimed evaluate placement using a goggle-based AR system compared an ultrasound (US)-based fusion navigation system. Methods Six interventional radiologists performed 24 independent placements anthropomorphic phantom (CIRS 057A) four cohorts ( n = 6 each): (1) US-based fusion, (2) with...
Water-fat separation is a non-linear non-convex parameter estimation problem in magnetic resonance imaging typically solved using spatial constraints. However, there still limited knowledge on how to separate vivo three chemical species the presence of field inhomogeneities. The proposed method uses multiple graph-cuts hierarchical multi-resolution framework perform robust breast for subjects with and without silicone implants. Experimental results show that can decrease computational time...
There is a clinical need for non-ionizing, quantitative assessment of breast density, as one the strongest independent risk factors cancer. This study aims to establish proton density fat fraction (PDFF) biomarker tissue concentration in MRI and correlate mean PDFF mammography.In this retrospective study, 193 women were routinely subjected 3-T using six-echo chemical shift encoding-based water-fat sequence. Water-fat separation was based on signal model accounting single T2* decay...
To characterize the tumor extracellular matrix (ECM) using native T1 mapping magnetic resonance imaging (MRI) in an experimental hepatic cancer model, a total of 27 female New Zealand white rabbits with VX2 tumors were examined by MRI at different time points following implantation (day 14, 21, 28). A steady-state precession readout single-shot MOLLI sequence was acquired 3 T scanner prone position head-neck coil. The segmented into central, marginal, and peritumoral region anatomical images...
To investigate the imaging performance of an elastin-specific molecular magnetic resonance (MRI) probe with respect to extracellular matrix (ECM) in experimental hepatic cancer model. Twelve rabbits VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent (gadobutrol, day 1; probe, 2). The relative enhancement (RE) segmented regions (central margin) peritumoral was calculated pre-contrast delayed-phase T1w sequences. measurements correlated...
To (a) develop a preconditioned water-fat-silicone total field inversion (wfsTFI) algorithm that directly estimates the susceptibility map from complex multi-echo data in breast presence of silicone and to (b) evaluate performance wfsTFI for quantitative mapping (QSM) silico vivo comparison with formerly proposed methods.Numerical simulations gradient echo measurements were performed compare previously map-based linear (lTFI) without consideration chemical shift estimation step....
Early stage malignant tumors are often accompanied by microcalcifications. X-ray-based mammography examinations routinely used for screening and early detection due to the excellent contrast of calcified structures. However, damaging nature x-ray radiation, use an MR-based technique would be desirable repeated examinations. In this work, we present initial results quantitative-susceptibility-mapping-based (QSM) mammography-like MR-images that show robust calcifications down resolution MR...
With rising breast augmentations worldwide, there is an increasing clinical need for early and accurate detection of implant complications.
Intratumoral injections have the potential for enhanced cancer treatment efficacy while reducing costs and systemic exposure. However, intratumoral drug can result in substantial off-target leakage are invisible under standard imaging modalities like ultrasound (US) x-ray. A thermosensitive poloxamer-based gel delivery was developed that is visible using x-ray (computed tomography (CT), cone beam CT, fluoroscopy), as well US by means of integrating perfluorobutane-filled microbubbles (MBs)....
Although unlimited sessions of conventional transarterial chemoembolization (cTACE) may be performed for liver metastases, there is no data indicating when treatment becomes ineffective. This study aimed to determine the optimal number repeat cTACE nonresponding patients before abandoning in with metastases. In this retrospective, single-institutional analysis, metastases from neuroendocrine tumors (NET), colorectal carcinoma (CRC), and lung cancer who underwent consecutive 2001 2015 were...
Breast microcalcifications (MCs) can be the only sign of carcinoma and other precursor lesions breast cancer in x-ray mammography. Mammography is routinely used for population-based screening. However, due to ionizing nature radiation, use an MR-based technique would desirable repeated examinations especially screening targeted sub-cohorts at high-risk or younger women. In this work, we present initial results on visualization MCs using MR with optimized high-resolution GRE-scan quantitative...
Intratumoral injections often lack visibility, leading to unpredictable outcomes such as incomplete tumor coverage, off-target drug delivery and systemic toxicities. This study investigated an ultrasound (US) x-ray imageable thermosensitive hydrogel based on poloxamer 407 (POL) percutaneously delivered in a healthy swine model. The primary objective was assess the 2D 3D distribution of within tissue across three different needle devices injection sites: liver, kidney, intercostal muscle...
Motivation: Quantitative susceptibility mapping (QSM) has recently been used to detect breast microcalcifications (MCs) which could be the precursor lesions breast-carcinoma. However, acquiring high-resolution (HR) QSM maps reduces signal-to-noise ratio (SNR), making detection of MCs challenging. Goal(s): Improve SNR in HR-QSM for better visualization using deep-learning-based denoising. Approach: A complex-valued bias-free CNN (CV-BFCNN), adapted from real-valued BFCNN, was trained on MR...
Abstract Intratumoral injections have the potential for enhanced cancer treatment efficacy while reducing costs and systemic exposure. However, intratumoral drug can result in substantial off-target leakage are invisible under standard imaging modalities like ultrasound (US) x-ray. A thermosensitive poloxamer-based gel delivery was developed that is visible using x-ray (computed tomography (CT), cone beam CT, fluoroscopy), as well US by means of integrating perfluorobutane-filled...