A5079995719- Probiotics and Fermented Foods
- Gut microbiota and health
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Microbial Metabolites in Food Biotechnology
- Nanoparticles: synthesis and applications
- Sperm and Testicular Function
- Advanced Proteomics Techniques and Applications
- Antimicrobial Peptides and Activities
- Reproductive System and Pregnancy
- Protein Hydrolysis and Bioactive Peptides
- Immune Cell Function and Interaction
- Digestive system and related health
- Cytokine Signaling Pathways and Interactions
- Nuclear Structure and Function
- S100 Proteins and Annexins
- Reproductive Physiology in Livestock
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Biochemical and Structural Characterization
- Phytoestrogen effects and research
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
Heidelberg University
2022-2025
German Cancer Research Center
2022-2025
University of Nebraska–Lincoln
2025
University of Louisiana at Lafayette
2022-2024
National Dairy Research Institute
2016-2024
Indian Council of Agricultural Research
2022-2024
Heidelberg University
2024
Washington University in St. Louis
2023
European Molecular Biology Laboratory
2021
Kothiwal Dental College and Research Centre
2018
In the current scenario, it is an urgent requirement to satisfy nutritional demands of rapidly growing global population. Using conventional farming, nearly one third crops get damaged, mainly due pest infestation, microbial attacks, natural disasters, poor soil quality, and lesser nutrient availability. More innovative technologies are immediately required overcome these issues. this regard, nanotechnology has contributed agrotechnological revolution that imminent potential reform resilient...
Numerous studies have shown a link between the consumption of fermented dairy foods and improved health outcomes. Since early 2000s, especially probiotic-based functional foods, had revival in popularity, mostly as consequence claims made about their benefits. Among them, been associated with obesity prevention other conditions such chronic diarrhea, hypersensitivity, irritable bowel syndrome, Helicobacter pylori infection, lactose intolerance, gastroenteritis which all are intimately linked...
The guanine nucleotide exchange factor (GEF) epithelial cell transforming sequence 2 (Ect2) has been implicated in cancer. However, it is not clear how Ect2 causes transformation and whether necessary for tumorigenesis vivo. Here, we demonstrate that nuclear GEF activity required Kras-Trp53 lung vivo Ect2-mediated requires Ect2-dependent rDNA transcription. activates rRNA synthesis by binding the nucleolar transcription upstream 1 (UBF1) on promoters recruiting Rac1 its downstream effector...
Human plasma is one of the most widely used tissues in clinical analysis, and plasma-based biomarkers are for monitoring patient health status and/or response to medical treatment avoid unnecessary invasive biopsy. Data-driven proteomics has suffered from a lack throughput detection sensitivity, largely due complexity proteome particular enormous quantitative dynamic range, estimated be between 9 13 orders magnitude lowest highest abundance protein. A major challenge identify workflows that...
Ribosomal RNA (rRNA) genes are down-regulated during osteogenesis, myogenesis, and adipogenesis, necessitating a mechanistic understanding of interrelationships between growth control phenotype commitment. Here, we show that cell fate-determining factors [MyoD, myogenin (Mgn), Runx2, C/EBPbeta] occupy rDNA loci suppress rRNA expression lineage progression, concomitant with decreased reciprocal loss occupancy by c-Myc, proliferation-specific activator transcription. We find interaction...
The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated metastatic breast prostate cancer cells. Thus, Runx2 may function as a tumor suppressor or an oncogene depending on the cellular context. Here we show that Runx2-deficient primary osteoblasts fail to undergo senescence indicated by absence of beta-gal activity p16(INK4a) expression. Primary Runx2-null have growth...
The Runt-related transcription factor Runx2 is essential for bone development but also implicated in progression of several cancers breast, prostate and bone, where it activates cancer-related genes promotes invasive properties. transforming growth β (TGF-β) family member morphogenetic protein-3B (BMP-3B/GDF10) regarded as a tumor inhibitor gene silenced lung cancers; however the regulatory mechanisms leading to its silencing have not been identified.Here we show that highly expressed cancer...
An early, reliable and noninvasive method of early pregnancy diagnosis is prerequisite for efficient reproductive management in dairy industry. The detection also help to reduce the calving interval rebreeding time which beneficial industries as well farmers. aim this work identify potential biomarker at earlier stages (16-25 days). To achieve goal we performed DIGE LFQ identification protein has significant differential expression during pregnancy.DIGE experiment revealed a total eleven...
Enhancing Male Reproductive Function through Activation of the Hypothalamic-Pituitary-Adrenal Axis: Mitigation Restraint Stress-Induced Deficits via Oral Probiotic Administration.
Abstract HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model barcoded SIVmac239 intravenous infection and therapeutic dosing anti-TGFBR1 inhibitor galunisertib (LY2157299), we confirm latency reversal properties vivo TGF-β blockade, decrease stimulate responses. Treatment eight female, SIV-infected macaques on with four 2-weeks cycles leads reactivation as indicated by plasma load immunoPET/CT a 64 Cu-DOTA-F(ab’)...