A. Fuchs

ORCID: 0000-0003-3028-0827
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About
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Research Areas
  • CAR-T cell therapy research
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research
  • Spine and Intervertebral Disc Pathology
  • Anesthesia and Pain Management
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • CRISPR and Genetic Engineering
  • Hematopoietic Stem Cell Transplantation
  • Bacteriophages and microbial interactions
  • Nerve Injury and Rehabilitation
  • Photosynthetic Processes and Mechanisms
  • Surgical Simulation and Training
  • Nanoplatforms for cancer theranostics
  • Congenital Anomalies and Fetal Surgery
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Infections and bacterial resistance
  • Pharmaceutical studies and practices
  • Biomedical and Chemical Research
  • Abdominal Trauma and Injuries
  • Machine Learning in Bioinformatics
  • Organ Transplantation Techniques and Outcomes
  • Bacillus and Francisella bacterial research
  • COVID-19 and healthcare impacts
  • Human Health and Disease

Technische Universität Dresden
2017-2024

University Hospital Carl Gustav Carus
2008-2019

Klinik und Poliklinik für Psychotherapie und Psychosomatik
2018

Berlin-Brandenburger Centrum für Regenerative Therapien
2018

Universität Innsbruck
2000

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety autoimmune and allergic diseases as well post-transplant complications. Nevertheless, current manufacturing Tregs a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons results studies performed. While number clinical trials testing is already substantial, it seems to be crucial provide some standardised characteristics Treg...

10.3389/fimmu.2017.01844 article EN cc-by Frontiers in Immunology 2018-01-15

Adoptive transfer of T regulatory cells (Treg) has been successfully exploited in the context graft-versus-host disease, transplantation, and autoimmune disease. For majority applications, clinical administration Treg requires laborious ex vivo expansion typically involves open handling for culture feeds repetitive sampling. Here we show results from our approach to translate manual manufacturing fully closed automated CliniMACS Prodigy® system reducing contamination risk, hands-on time,...

10.3389/fimmu.2019.00038 article EN cc-by Frontiers in Immunology 2019-01-31

This study was conducted to characterize and compare peripheral blood stem cell grafts from healthy donors who underwent granulocyte colony-stimulating factor (G-CSF) mobilization subsequently received 1 dose of plerixafor after insufficient yields were achieved at the first apheresis. Aliquots 35 collected apheresis with G-CSF alone second additional administration. Samples freshly analyzed for cellular subsets by 8-color flow cytometry. Leukapheresis samples mobilized showed a significant...

10.1016/j.bbmt.2018.06.023 article EN cc-by-nc-nd Biology of Blood and Marrow Transplantation 2018-06-21

The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies overcome underlying genetic functional aberrations. establishment the Centre Excellence for Technologies Gene Cell Therapy (CTGCT) at National Institute Chemistry (NIC) in Ljubljana represents a significant step forward, as it is first centre its kind Slovenia. CTGCT poised spearhead advances cancer immunotherapy personalised therapies...

10.1016/j.csbj.2024.11.051 article EN cc-by-nc-nd Computational and Structural Biotechnology Journal 2024-12-02

Mesenchymal-epithelial transition (MET) has been associated with secondary tumor outgrowth during metastasis but the underlying mechanism remains elusive. Using MET-inducible mesenchymal breast cancer cells, we investigated whether MET benefits by enhancing proliferation. We found that crowding inhibition of proliferation is present before and after MET, cells gain a proliferative advantage through more effective escape from crowded cell islands. In 3D culture, reduced upon differential...

10.1101/2024.09.23.614448 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-09-23
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