A5026029795- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Spine and Intervertebral Disc Pathology
- Anesthesia and Pain Management
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- Bacteriophages and microbial interactions
- Nerve Injury and Rehabilitation
- Photosynthetic Processes and Mechanisms
- Surgical Simulation and Training
- Nanoplatforms for cancer theranostics
- Congenital Anomalies and Fetal Surgery
- Phenothiazines and Benzothiazines Synthesis and Activities
- Infections and bacterial resistance
- Pharmaceutical studies and practices
- Biomedical and Chemical Research
- Abdominal Trauma and Injuries
- Machine Learning in Bioinformatics
- Organ Transplantation Techniques and Outcomes
- Bacillus and Francisella bacterial research
- COVID-19 and healthcare impacts
- Human Health and Disease
Technische Universität Dresden
2017-2024
University Hospital Carl Gustav Carus
2008-2019
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2018
Berlin-Brandenburger Centrum für Regenerative Therapien
2018
Universität Innsbruck
2000
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety autoimmune and allergic diseases as well post-transplant complications. Nevertheless, current manufacturing Tregs a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons results studies performed. While number clinical trials testing is already substantial, it seems to be crucial provide some standardised characteristics Treg...
Adoptive transfer of T regulatory cells (Treg) has been successfully exploited in the context graft-versus-host disease, transplantation, and autoimmune disease. For majority applications, clinical administration Treg requires laborious ex vivo expansion typically involves open handling for culture feeds repetitive sampling. Here we show results from our approach to translate manual manufacturing fully closed automated CliniMACS Prodigy® system reducing contamination risk, hands-on time,...
This study was conducted to characterize and compare peripheral blood stem cell grafts from healthy donors who underwent granulocyte colony-stimulating factor (G-CSF) mobilization subsequently received 1 dose of plerixafor after insufficient yields were achieved at the first apheresis. Aliquots 35 collected apheresis with G-CSF alone second additional administration. Samples freshly analyzed for cellular subsets by 8-color flow cytometry. Leukapheresis samples mobilized showed a significant...
The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies overcome underlying genetic functional aberrations. establishment the Centre Excellence for Technologies Gene Cell Therapy (CTGCT) at National Institute Chemistry (NIC) in Ljubljana represents a significant step forward, as it is first centre its kind Slovenia. CTGCT poised spearhead advances cancer immunotherapy personalised therapies...
Mesenchymal-epithelial transition (MET) has been associated with secondary tumor outgrowth during metastasis but the underlying mechanism remains elusive. Using MET-inducible mesenchymal breast cancer cells, we investigated whether MET benefits by enhancing proliferation. We found that crowding inhibition of proliferation is present before and after MET, cells gain a proliferative advantage through more effective escape from crowded cell islands. In 3D culture, reduced upon differential...