A5069802421- Ion Channels and Receptors
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Education and Critical Thinking Development
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Postharvest Quality and Shelf Life Management
- Neuroscience and Neuropharmacology Research
University of Leeds
2018-2024
Durham University
2024
Inserm
2018
Background: Orai1 is a critical ion channel subunit, best recognized as mediator of store-operated Ca 2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged key contributor cardiac hypertrophy and heart failure but the relevance still unclear. Methods: To test role these channels pathophysiology, transgenic mouse was generated with cardiomyocyte-specific expression an pore-disruptive R91W mutant (C-dnO1). Synthetic chemistry screening strategies were used to develop...
Background and Purpose The diterpene ester tonantzitlolone (TZL) is a natural product, which displays cytotoxicity towards certain types of cancer cell such as renal carcinoma cells. effect similar to that (‐)‐englerin A, so, although it chemically distinct, we investigated whether TZL also targets transient receptor potential canonical (TRPC) channels the 1, 4 5 type (TRPC1/4/5 channels). Experimental Approach effects on A498 cells natively expressing TRPC1 TRPC4, modified HEK293...
Calcium (Ca 2+ ) is a key second messenger in eukaryotes, with store-operated Ca entry (SOCE) being the main source of influx into non-excitable cells. ORAI1 highly -selective plasma membrane channel that encodes SOCE. It ubiquitously expressed mammals and has been implicated numerous diseases, including cardiovascular disease cancer. A number small molecules have identified as inhibitors SOCE variety potential therapeutic uses proposed validated vitro vivo . These encompass both...
This paper presents the findings from a detailed study investigating UK undergraduate students’ experience of practical science in their post-16 studies during COVID-19 pandemic. It also examines perceived confidence and preparedness relation to areas skills at start courses. The employed an exploratory sequential mixed methods design. Findings student focus groups held end were used support development comprehensive audit quantitative survey for incoming students. Survey data collected...