A5102898304- Calcium signaling and nucleotide metabolism
- PARP inhibition in cancer therapy
- Sirtuins and Resveratrol in Medicine
- Injection Molding Process and Properties
- Statistical Methods in Clinical Trials
- Manufacturing Process and Optimization
- Additive Manufacturing and 3D Printing Technologies
- Computational Drug Discovery Methods
- Pharmaceutical studies and practices
Daiichi Sankyo (United States)
2019-2021
Daiichi Sankyo (Germany)
2010
Draper Laboratory
1994
Abstract Pharmacological strategies that boost intracellular NAD + are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production mononucleotide (NMN), the predominant precursor in mammalian cells. A high-throughput screen NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound structurally similar active-site directed inhibitors blocks binding these NAMPT. SBI-797812 shifts reaction...
Proof of concept (POC) may be defined as the earliest point in drug development process at which weight evidence suggests that it is "reasonably likely" key attributes for success are present and causes failure absent. POC multidimensional but focused on that, if not addressed, represent a threat to project crucial areas such safety, efficacy, pharmaceutics, commercial regulatory issues. The appropriate assessed through use mathematical models by evaluating consequences advancing candidate...
Composites are becoming more common in manufacturing today, but the high cost of materials and production still deterrents for many applications. Currently one most effective processes is Resin Transfer Moulding (RTM). To improve effectiveness composite using RTM, a new process, Flexible (FRTM®), being developed. FRTM® lowers lay–up tooling costs by injecting resin into fabric placed between two flat flexible diaphragms. A formal design methodology has been used to develop process deform...