A5068371803- PI3K/AKT/mTOR signaling in cancer
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Protein Tyrosine Phosphatases
- Cancer therapeutics and mechanisms
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Pharmaceutical Economics and Policy
- Biotechnology and Related Fields
- Pharmacology and Obesity Treatment
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Biomedical and Engineering Education
- Quality and Safety in Healthcare
- Enzyme Catalysis and Immobilization
- Natural Antidiabetic Agents Studies
- RNA and protein synthesis mechanisms
Manipal Academy of Higher Education
2020-2024
Abstract This study aimed to identify new compounds capable of decreasing pancreatic lipase (PL) catalytic activity. A panel structurally related chalcones with hydroxy and chloro substituents was chosen, their inhibitory effects on the targeted enzyme were assessed. work also optimized conditions for UV/Vis spectrophotometric fluorimetric microanalysis systems and, whenever possible, a structure–activity relationship analysis performed. The obtained results showed effectiveness both...
This computational study exclusively illustrates the key molecular features of bedaquiline and its analogues required for binding to mycobacterial ATP synthase.
Healthcare of an individual is prime importance as this directly proportional to the productivity a country. With booming technological innovations, healthcare sector updating with use latest devices for treatment patients. However, compared global scenario, medical device industry in India still infancy stage, lots opportunities sector. Therefore, and attempt made understand past present updates area India.
This research is an attempt to develop novel indole-2-carboxamides as antitubercular agents and understand their binding interactions at the catalytic site. In this study, mycobacterial membrane protein Large 3 (MmpL3) was chosen drug target indole-2-carboximides were designed, synthesized, screened for activity. Molecular modelling techniques designing validation included building a homology model, docking, MMGBSA. A total of 12 molecules synthesized tested against H37Rv strain...
This research aimed to develop novel indole-2-carboxamides as potential antitubercular agents using rational drug design. It also focused on identifying the critical interactions required for these compounds exhibit effective activity.
Tuberculosis is an infectious air-borne disease and one of the leading causes death globally among all diseases. There urgent need to develop antitubercular drugs that would be highly efficient less toxic than presently available marketed drugs. Mycobacterium membrane protein large 3 (MmpL3) emerging drug target in tuberculosis with various classes molecules have been known inhibit it. In this study, a dataset indole-2-carboxamides showing activity by inhibiting MmpL3 was utilized....
Antibiotics are robust medicines that widely used from centuries together to treat bacterial infections such as UTI, Typhoid, and Cholera etc. The similarity between viral infection has resulted in the misuse of these antibiotics, result which is development resistant strains. Such indiscriminate drug usage been increasing a vulnerable geriatric pediatric population. increase per capita health expenditure enhanced global market class drugs, scope likely shoot up coming years, paving way for...