A5101752178- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Antifungal resistance and susceptibility
- Neurofibromatosis and Schwannoma Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Reasoning and Diagnostic Skills
- Respiratory Support and Mechanisms
- Non-Invasive Vital Sign Monitoring
- Autopsy Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Inflammation biomarkers and pathways
- Dialysis and Renal Disease Management
- Copper Interconnects and Reliability
- Amyotrophic Lateral Sclerosis Research
- Clinical Nutrition and Gastroenterology
- Soft tissue tumors and treatment
- Genetic and Kidney Cyst Diseases
- Mast cells and histamine
- Muon and positron interactions and applications
- Infectious Diseases and Mycology
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Peking Union Medical College Hospital
2011-2024
Biogen (United States)
2017-2022
Panzhihua Central Hospital
2020
Sun Yat-sen University
2016-2019
The First Affiliated Hospital, Sun Yat-sen University
2016-2019
University of Iowa
2013
Union Hospital
2006
National Institute of Standards and Technology
2002
Longitudinal structural MRI studies have shown that patients with schizophrenia progressive brain tissue loss after onset. Recurrent relapses are believed to play a role in this loss, but the relationship between relapse and measures has not been rigorously assessed. The authors analyzed longitudinal data examine question.The studied from 202 drawn Iowa Study of first-episode for whom adequate were available (N=659 scans) scans obtained at regular intervals over an average 7 years. Because...
Abstract Introduction We investigated whether combining the peripheral perfusion index (PI) and central venous oxygen saturation(ScvO 2 ) would identify subsets of patients for assessing tissue predicting outcome during resuscitation in critically ill patients. Methods A total 202 with catheters were enrolled this prospective observational study. The arterial, blood gas PI measured simultaneously at enrollment (T0) 8 h (T8) after early resuscitation. Based on distribution healthy population,...
Recently, the central venoarterial carbon dioxide difference/arterial-central venous oxygen difference (P(v-a)CO2/C(a-v)O2) ratio has been suggested as an additional indicator of anaerobic metabolism. We investigated relationship between P(v-a)CO2/C(a-v)O2 and 8-hour lactate clearance (LC) in septic patients after resuscitation.We prospectively obtained 168 sets measurements from 84 patients. The arterial blood gases were measured simultaneously at enrollment 8 hours resuscitation. (r =...
Bladder cancer is a common malignancy that arises from the urothelium. Treatment options for advanced bladder remain limited, particularly in patients who have progressed after first-line therapy. Immunotherapy with programmed death-ligand 1 (PD-L1) inhibitors, such as durvalumab, has shown promise improving outcomes these patients. Radiotherapy (RT) another modality can be integrated to enhance local tumour control. This study explored efficacy and safety of combining durvalumab RT...
Key points• Microcirculatory impairment is a key pathogenetic mechanism in acute kidney injury associated with severe disease.• CEUS "microscope" of the renal microcirculation.• quantitatively assesses microcirculation to help guide hemodynamic therapy critical care-related injury.• challenging but necessary differentiate regional blood flow within kidney.• parameters can be used as sensitive indicators assess prognosis AKI.
Sclerosing angiomatoid nodular transformation (SANT) is a rare benign splenic vascular lesion. Since it was first defined in 2004, total of 132 cases SANT have been reported ~50 studies the English literature. However, remains difficult to form definitive pre-operative differential diagnosis compared with other tumors or malignant lesions. The present study reports pathologically proven case 29-year-old man who initially presented left upper quadrant and back discomfort. also provides review...
Abstract X‐ray reflectivity has been used to determine the mass uptake of probe molecules in porous thin films supported on thick silicon wafers. The adsorption occurs by capillary condensation when are exposed vapor at controlled partial pressures. solvent pressure was varied mixing saturated air and dry constant temperature or changing sample a concentration. Pore size distribution can be calculated from with typical porosimetric approaches such as application Kelvin equation convert into...
After cardiac surgery, central venous oxygen saturation (ScvO 2 ) and serum lactate concentration are often used to guide resuscitation; however, neither completely reliable indicators of global tissue hypoxia. This observational study aimed establish whether the ratio between veno-arterial carbon dioxide arterial-venous differences (P(v-a)CO /C(a-v)O could predict patients would respond resuscitation by increasing delivery (DO ).We selected 72 from a cohort 290 who had undergone surgery in...
Renal perfusion status remains poorly studied at the bedside during sepsis associated acute kidney injury (AKI). The aim of study is to examine renal cortical and medullary using contrast enhanced ultrasound (CEUS) in septic patients.
Objective The perfusion index (PI) is usually used to assess peripheral perfusion, which can be influenced by the cardiac (CI). CI monitoring often needed during treatment of patients with shock. We investigated relationship between changes in PI (ΔPI) and (ΔCI) septic Methods This retrospective study included shock who underwent pulse-induced continuous output monitoring. measured before after fluid loading first 6 hours intensive care unit admission. Fluid responsiveness was defined as a...
Abstract Background To investigate the epidemiology and in-hospital mortality of veno-venous (VV) veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) in Mainland China throughout 2018. Methods Patients supported by ECMO from 1700 tertiary hospitals 31 provinces January 1 to December 31, 2018, were selected National Clinical Improvement System database. Results The included had 2073 cases including 714 VV 1359 VA ECMOs. average patient age was 50 years (IQR 31–63), 1346 male....
The transcutaneous partial pressure of oxygen (PtcO₂) index has been used to detect low-flow state in circulatory failure, but the value challenge test (OCT) estimate low cardiac output not thoroughly evaluated. prospective observational study examined 62 septic patients requiring PiCCO-Plus for monitoring. Simultaneous basal blood gases from arterial, central venous catheters were obtained. Cardiac indices measured by transpulmonary thermodilution technique at same time, then 10-min...
Aspergillosis infection is common in the patients with insufficient immunity. The role of mammalian target rapamycin (mTOR), T-box expressed T-cells (T-bet), and eomesodermin (EOMES) mediating T lymphocytes differentiation response to Aspergillus fumigatus immunocompromised rats was investigated this study.Invasive pulmonary aspergillosis (IPA) immunosuppressive twenty male were established sacrificed at 24 h (n = 5), 48 72 96 5) after A. infection. In addition, control cyclophosphamide...
Microcirculation dysfunction with blood flow heterogeneity is an important characteristic in sepsis shock. We hypothesized that impaired ability of red cells to release nitric oxide resulted microcirculation shock.4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate (DIDS), inhibitor band3 protein, was used inhibit S-nitrosohemoglobin-mediated release. Rabbits were randomly divided into four groups: control (n = 6), lipopolysaccharide (LPS) LPS + DIDS and group 6)....
Early goal-directed therapy (EGDT) has been used in clinics as a standard procedure sepsis resuscitation for long period. However, the ProCESS, ARISE, and ProMISe trials did not find any benefits from EGDT on mortality, triggering considerable doubt, reassessment field of intensive care medicine. The heterogeneity studied patients, differences trial designs interventions may have led to these disappointing results; however, improving oxygenation tissue perfusion early possible is core issue...
More and more serious global warming boosters the research on environmental protection from both industries academia. The collection of data is a basic block for protection. Due to mobility release stringent power constraints, vehicular sensor networks (VSN) provides an efficient way collect data. However, many existing work application VSN in focuses using collected generate report. increasing popularity social motivates our interests providing innovative applications by integrating with...
Poor tissue perfusion/cellular hypoxia may persist despite restoration of the macrocirculation (Macro). This article reviewed literatures coherence between hemodynamics and perfusion in circulatory shock.We retrieved information from PubMed database up to January 2018 using various search terms or/and their combinations, including resuscitation, shock, septic perfusion, hemodynamic coherence, microcirculation (Micro).The data peer-reviewed journals printed English on relationships...