A5083591826- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Advanced Nanomaterials in Catalysis
- Histone Deacetylase Inhibitors Research
- Adipose Tissue and Metabolism
- Antimicrobial Peptides and Activities
- Fungal Infections and Studies
- Diet, Metabolism, and Disease
- Carbon and Quantum Dots Applications
- Chemotherapy-induced organ toxicity mitigation
- Metabolism, Diabetes, and Cancer
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Electrochemical sensors and biosensors
- Pancreatic function and diabetes
- Magnetic Properties and Synthesis of Ferrites
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Genomics and Chromatin Dynamics
- Nanoparticles: synthesis and applications
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
National Institute of Pharmaceutical Education and Research
2015-2025
National Institute of Pharmaceutical Education and Research
2016-2025
National Institute of Pharmaceutical Education and Research
2013-2024
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Institut de l'Information Scientifique et Technique
2023
University of Nebraska Medical Center
2023
National Institute of Pharmaceutical Education and Research
2022
Government of India
2021
Guru Angad Dev Veterinary and Animal Sciences University
2020
Certain medicinal plants utilized in the traditional ayurvedic system are poisonous when used raw, but following a detoxification process. The Ayurvedic Formulary of India (AFI) provides details about these (known as "sodhana") processes per procedures. This research endeavor aimed to uncover fundamental principles underlying approach applied Plumbago zeylanica, commonly referred "swet chitrak", which plumbagin is primary toxic constituent. Both unprocessed and processed (detoxified)...
Gold nanoparticles (AuNPs) are used enormously in different cancers but very little is known regarding their molecular mechanism and surface charge role the process of cell death. Here, we elucidate by which differentially charged AuNPs induce cytotoxicity triple negative breast cancer (TNBC) cells. Cytotoxicity assay revealed that both negatively (citrate-capped) positively (cysteamine-capped) induced cell-death a dose-dependent manner. We provide first evidence AuNPs-induced oxidative...
Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder. Various pre-clinical and clinical studies have shown that melatonin (MEL) has beneficial effects in cancer. However, elucidation of the detailed molecular mechanisms involved MEL-mediated protection against colon deserves further investigation. The present study was aimed at deciphering effect MEL on autophagy Nrf2 signaling pathways mouse model colitis-associated (CACC)....
Curcumin has been used to treat cancer, diabetes and other pathologies. However, little is known regarding its role in altering post-translational modifications of histone H3. A recent report suggests that acute hyperglycaemia induces a global down-regulation gene expression human tissues epigenetic regulation could be novel mechanism underlying the pathological processes hyperglycaemia. The present study was undertaken examine changes modification by curcumin treatment which prevents...
Diabetic nephropathy (DN) is one of the main causes end stage renal disease (ESRD) and a leading cause diabetes mellitus related morbidity mortality. Recently, sirtuin are reported to have emerging pathogenetic roles in cancer, muscle differentiation, heart failure, neurodegeneration, aging. The aim present study was role intermittent fasting (IF) on DN studying expression Sir2 p53. At biochemical level, we found that IF significant improvement blood urea nitrogen (BUN), creatinine, albumin...
Background. Distinct histone modifications regulate gene expression in certain diseases but little is known about epigenetics diabetic nephropathy. The current study examined the role of development and progression nephropathy db/db mice.
The purpose of this study was to develop folic acid functionalized long-circulating co-encapsulated docetaxel (DTX) and curcumin (CRM) solid lipid nanoparticles (F-DC-SLN) improve the pharmacokinetic efficacy DTX therapy. F-DC-SLN prepared by hot melt-emulsification method optimized face centered-central composite design (FC-CCD). SLN characterized in terms size distribution, drug entrapment efficiency release profile. cytotoxicity cell uptake formulations were evaluated MCF-7 MDA-MB-231...
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased ratio of classically activated M1 macrophages/Kupffer cells to alternatively M2 macrophages, which plays imperative role in the development and progression NAFLD. However, little known about precise mechanism behind macrophage polarization shift. Here, we provide evidence regarding relationship between shift Kupffer autophagy resulting from lipid exposure. High-fat high-fructose diet supplementation for 10 weeks...