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Neil A. Miller

ORCID: 0000-0003-3077-5790
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About
Contact & Profiles
A5012173842
Research Areas
  • Inhalation and Respiratory Drug Delivery
  • Asthma and respiratory diseases
  • Pharmacogenetics and Drug Metabolism
  • Drug Solubulity and Delivery Systems
  • Analytical Methods in Pharmaceuticals
  • Pharmaceutical studies and practices
  • Computational Drug Discovery Methods
  • Advanced Chemical Sensor Technologies
  • Analytical Chemistry and Chromatography

Simulations Plus (United States)
 2021-2023

GlaxoSmithKline (United Kingdom)
 2019

 Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs Using Physiologically Based Biopharmaceutics Modeling: Industry Case Studies
OPENALEX - Publications 
Amitava Mitra Neil Parrott Neil A. Miller Richard Lloyd Christophe Tistaert and 3 more Tycho Heimbach Yan Ji Filippos Kesisoglou

10.1016/j.xphs.2019.11.017 article EN Journal of Pharmaceutical Sciences 2019-11-25
 Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption
OPENALEX - Publications 
Neil A. Miller Rebecca H. Graves Chris D. Edwards Augustin Amour Ed Taylor and 5 more Olivia Robb Brett A. O’Brien Aarti Patel Andrew W. Harrell Edith M. Hessel

Physiologically based pharmacokinetic (PBPK) modelling has evolved to accommodate different routes of drug administration and enables prediction concentrations in tissues as well plasma. The inhalation route proven successful treating respiratory diseases but can also be used for rapid systemic delivery, holding great promise treatment requiring exposure. objective this work was develop a PBPK model that predicts plasma tissue following the PI3Kδ inhibitor nemiralisib.A built GastroPlus®...

10.1007/s40262-021-01066-2 article EN cc-by-nc Clinical Pharmacokinetics 2021-08-30
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