A5057757133- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
The University of Texas Health Science Center at San Antonio
2023
The University of Texas Health Science Center at Houston
2023
Abstract Bromodomain‐containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse model, we find that deletion ( Δ/Δ ) hematopoietic system impairs stem cell (HSC) self‐renewal differentiation, which associates with cycle arrest senescence. ATAC‐seq analysis shows increased chromatin accessibility stem/progenitor cells...
Abstract Bromodomain containing protein 4 (BRD4) is an epigenetic transcription regulator that reads acetylated chromatin and involved in the recruitment of transcriptional factors to initiate gene transcription. BRD4 functionally versatile has extensively been studied for its role cell cycle progression, regulation, organization remodeling, as well DNA replication repair. In addition, implicated many solid liquid tumors, inhibition shows promising preclinical activity, especially...