A5051356701- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Eosinophilic Disorders and Syndromes
- Glutathione Transferases and Polymorphisms
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Oral Health Pathology and Treatment
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
Universiti Sains Malaysia
2014-2024
Hospital Universiti Sains Malaysia
2009-2024
Noorul Islam College of Dental Science
2022-2024
Jubilee Mission Medical College and Research Institute
2023-2024
Kerala University of Health Sciences
2024
Saveetha University
2022
University School of Milwaukee
2018
Regional Cancer Center, Thiruvananthapuram
1992-2008
Govt. Dental College & Hospital
1997
AbstractMost of the predisposition to hereditary breast and ovarian cancer has been attributed inherited defects in two tumor suppressor genes BRCA1 BRCA2. To explore contribution mutations among Indian women, we examined coding sequence gene 14 patients with a positive family history and/or cancer. Mutation analysis was carried out using conformation sensitive gel electrophoresis (CSGE) followed by sequencing. Three (21%) were identified. Two them are novel which one is missense mutation...
In response to many forms of cellular stress, including DNA damage, the p53 protein functions induce growth arrest, repair, or apoptosis. Common allele variants in TP53 gene modulate pathways lung carcinogenesis and susceptibility prognosis cancer. The prognostic role polymorphism was assessed 422 subjects using PCR-RFLP. Logistic regression analysis showed a dominant presentation Pro/Pro homozygotes carcinoma population than control (OR = 2.1, P 0.003). We further investigated association...
Information on the prevalence and type distribution of human papillomavirus (HPV) among Malaysian women is currently limited. The present study therefore aimed to provide an updated estimate HPV with without cervical cancer. Total DNA was isolated from cell specimens 185 histopathologically confirmed cancer patients 209 cancer-free healthy females who were tested negative in a recent Pap test. Viral-specific subsequently amplified biotinylated primers hybridized type-specific probes via...
Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients has emerged as a significant clinical problem. The observation that increased epigenetic silencing potential tumor suppressor genes correlates with disease progression some CML treated IM suggests relationship between and development. We hypothesize promoter hypermethylation HOXA4 could be an mechanism mediating patients. Thus study was undertaken investigate the status on treatment determine its...
Imatinib mesylate (IM), a selective inhibitor of the BCR-ABL tyrosine kinase, is well-established first-line treatment for chronic myeloid leukemia (CML). IM metabolized mainly by cytochrome P450 (CYP) in liver, specifically CYP3A4 and CYP3A5 enzymes. Polymorphisms these genes can alter enzyme activity may affect its response. In this study, impact two single-nucleotide polymorphisms (SNPs), CYP3A5*3 (6986A>G) CYP3A4*18 (878T>C), on response CML patients (n = 270; 139 resistant 131 good...
This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val158 Met, and SULT1A1 Arg213 His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used calculate odds ratios (ORs) 95% confidence intervals (95%CIs). Familial risk due wt/m1 m1/m1 genotypes 2.3 (1.51–3.61)-fold 7.1 (3.69–13.7)-fold, respectively. In addition the main effects, certain first-order interactions...
Cell-mediated and humoral immune responses were assessed in 50 patients with oral submucous fibrosis (OSMF) the results compared those of oral-leukoplakia, cancer patients, normal healthy adult controls. The number high-affinity rosette-forming cells (HARFC) was found to be significantly decreased OSMF cancer, whereas total (TRFC) remained unaltered. Levels serum IgA, IgD, IgE elevated both cancer. Immunologic derangements more pronounced than OSMF. enumeration HARFC along estimation levels...