A5069329734- Cardiac Fibrosis and Remodeling
- Genomics, phytochemicals, and oxidative stress
- Viral Infections and Immunology Research
- Phytochemicals and Antioxidant Activities
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Planarian Biology and Electrostimulation
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- melanin and skin pigmentation
- Moringa oleifera research and applications
- Cassava research and cyanide
- Pressure Ulcer Prevention and Management
- Polyamine Metabolism and Applications
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
- Synthesis and bioactivity of alkaloids
- Bladder and Urothelial Cancer Treatments
- Chemotherapy-induced organ toxicity mitigation
- Gastroesophageal reflux and treatments
- PI3K/AKT/mTOR signaling in cancer
- Skin Protection and Aging
- Tissue Engineering and Regenerative Medicine
- Allelopathy and phytotoxic interactions
- Helicobacter pylori-related gastroenterology studies
University of Cape Town
2020-2024
Cedars-Sinai Medical Center
2023-2024
Cedars-Sinai Smidt Heart Institute
2023-2024
Groote Schuur Hospital
2020-2024
National University of Sciences and Technology
2014-2018
University of Toronto
2018
Sunnybrook Hospital
2018
Sunnybrook Research Institute
2018
Fort Wayne Medical Institute
2018
Sunnybrook Health Science Centre
2018
The present study is intended to compare and document the therapeutic flora, their remedial use, traditional knowledge used frequently by residents of Cholistan desert Pothwar (Potohar) Plateau Punjab, Pakistan. old endemic remedies these areas are diminishing due lack qualitative quantitative research.The data was generated unstructured-interviews, informal meetings, open-ended conversations group discussions with local people health healers area. Reported literature also utilized.The...
Post-burn trauma significantly raises tissue serotonin concentration at the initial stages of injury, which leads us to investigate its possible role in post burn wound healing. Therefore, we planned this study examine healing through vitro and vivo models injuries. Results from analysis revealed that decreased apoptosis increased cell survival human fibroblasts neonatal keratinocytes. Cellular proliferation also both types. Moreover, stimulation accelerated migration, resulting narrowing...
To determine the effect of actively training crura diaphragm which is a part lower esophageal sphincter using abdominal breathing exercises to treat gastroesophageal reflux disease. With randomized controlled study design, total 22 (11 in each group) clinically diagnosed patients GERD presenting gastroenterology outpatient department at Holy Family Hospital Pakistan were assessed related "quality life index (QoLI)" questionnaire and their on-demand proton pump inhibitors (PPI) usage. Single...
Justicia adhatoda Linn is a medicinal shrub and its leaves roots have being used against diabetes in North East of Pakistan years ago. The effects J. adhatoda was studied alloxan induced diabetic animals. purpose this study to investigate the root extracts plant on blood glucose other parameters associated with diabetes. Oral administration 50 100 mg/kg ethanolic normal experimental rats produced significant (p < 0.05) reduction levels from 2 6 days treatment as compared extract (100 mg/kg)...
Objective: To Determine the phytochemical composition of E. sativa (stem, leaves, flowers and seeds), evaluate their antioxidant activity. Method: Preliminary screening for all parts seeds) was carried out according to standard methods. Total phenolic contents methanolic extracts sativa, have been quantified spectrophotometrically. Hydrogen Peroxidase 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical assays used analyze characteristics (leaves, stem, seed, seeds). Further separation...
Elevated levels of eukaryotic translation initiation factor 4E (eIF4E) enhance many malignancy-related proteins, such as vascular endothelial growth (VEGF), c-Myc and osteopontin. In non-small-cell lung cancer (NSCLC), eIF4E are significantly increased compared with normal tissue. Here, we used an antisense oligonucleotide (ASO) to inhibit the expression in NSCLC cell lines. were reduced a dose-dependent manner cells treated eIF4E-specific ASO (4EASO) control ASO. Treatment 4EASO resulted...
Skin wound healing is a multistage phenomenon that regulated by cell-cell interplay and various factors. Endogenous serotonin an important neurotransmitter cytokine. Its interaction with the 1A receptor (5-HTR1A) delivers downstream cellular effects. The role of (5-hydroxytryptamine, 5-HT) 5-HT1A has been established in regeneration tissues such as liver spinal motor neurons, prompting investigation skin healing. This study assessed excisional employing punch biopsy model on 5-Ht1a knockout...
Keloids are a common connective tissue disorder with an ill-understood etiopathogenesis and no effective treatment. This is exacerbated because of the absence animal model. Patient-derived primary keloid cells insufficient as they age through passaging have limited supply. Therefore, there unmet need for development cellular model that can consistently faithfully represent keloid’s pathognomic features. In view this, we developed keloid-derived immortalized fibroblast (KDIF) cell lines from...
Cardiac fibrosis contributes to end-stage extracellular matrix remodeling and heart failure (HF). fibroblasts (CFs) differentiate into myofibroblasts (myoFbs) preserve the structural integrity of heart; however, molecular mechanisms regulating CF transdifferentiation remain poorly understood. Protein arginine deiminase (PAD), which converts citrulline, has been shown play a role in myocardial infarction, fibrosis, HF. This study aimed investigate PAD differentiation myoFbs identify...
During investigating the role of peptidylarginine deiminase (PAD) enzymes in dilated cardiomyopathy (DCM), we observed unique spheroid formation DCM-myofibroblasts that distinguished them from normal cardiac myofibroblasts. The present study aimed to assess presence PADs, extracellular matrix (ECM), and citrullination DCM spheroids using immunofluorescence staining imaging techniques. results revealed derived displayed a more distinctive, tightly packed structure compared with those human...