Hsin-Yen Wang

ORCID: 0000-0003-3083-9328
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About
Contact & Profiles
Research Areas
  • DNA Repair Mechanisms
  • Action Observation and Synchronization
  • Chronic Myeloid Leukemia Treatments
  • RNA and protein synthesis mechanisms
  • Tactile and Sensory Interactions
  • Neurobiology of Language and Bilingualism
  • DNA and Nucleic Acid Chemistry
  • Genomic variations and chromosomal abnormalities
  • Epigenetics and DNA Methylation
  • Innovative Human-Technology Interaction
  • Eosinophilic Disorders and Syndromes
  • Stroke Rehabilitation and Recovery
  • Cytomegalovirus and herpesvirus research
  • Chromosomal and Genetic Variations
  • Chronic Lymphocytic Leukemia Research
  • Prenatal Screening and Diagnostics
  • Interactive and Immersive Displays

National Taiwan University
2008-2024

This case study in UbiComp technology and design presents a Playful Toothbrush system for assisting parents teachers to motivate kindergarten children learn proper thorough brushing skills. The includes vision-based motion tracker that recognizes different tooth strokes game which the child cleans virtual, mirror picture of his/her dirty teeth by physically own teeth. user results suggest enhances effectiveness their teeth, as measured number strokes, duration thoroughness cleaning.

10.1145/1357054.1357115 article EN 2008-04-06

Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance. This study develops a compound, JMF4073, inhibiting thymidylate (TMP) and cytidylate (CMP) kinases, aiming for new therapy against TKI-resistant CML. In vitro in vivo treatment JMF4073 eliminates WT-Bcr-Abl-32D CML cells. However, T315I-Bcr-Abl-32D cells are less vulnerable JMF4073. Evidence is presented that ATF4-mediated upregulation GSH be...

10.1038/s42003-024-06547-1 article EN cc-by Communications Biology 2024-07-10

Abstract This study used DNA methyltransferase 3b (DNMT3b) knockout cells and the functional loss of DNMT3b mutation in immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) to understand how dysfunction causes genome instability. We demonstrated that R-loops contribute damages ICF cells. More prominent damage signal was due expression acquirement p53 mutation. Genome-wide ChIP-sequencing mapped sites at satellite repetitive sequences including (peri-)centromere regions....

10.1038/s41419-022-04989-1 article EN cc-by Cell Death and Disease 2022-06-11

Measurement of four dNTP pools is important for investigating metabolism, genome stability, and drug action. In this report, we developed a two-step method quantitating dNTPs by the combination rolling circle amplification (RCA) quantitative polymerase chain reaction (qPCR). We used CircLigase to generate single-strand DNA in circular monomeric configuration, which was then first step RCA that contained three excess quantification one at limiting levels. The second products qPCR, primer...

10.1021/acs.analchem.1c03236 article EN Analytical Chemistry 2021-10-11

ABSTRACT This study investigates how DNA methyltransferase 3b (DNMT3b) dysfunction causes genome instability. We showed that in DNMT3b deficient cells, R-loops contribute to prominent γH2AX signal, which was mapped repetitive satellite sequences including centromere regions. By ChIP and DRIP analyses, our data revealed centromeric cells are removed by XPG/XPF, thus generating breaks centromeres increase mitotic aberration. In immunodeficiency-centromeric instability-facial anomalies (ICF)...

10.1101/2020.06.04.133272 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-06-04
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