A5036608827- DNA Repair Mechanisms
- Action Observation and Synchronization
- Chronic Myeloid Leukemia Treatments
- RNA and protein synthesis mechanisms
- Tactile and Sensory Interactions
- Neurobiology of Language and Bilingualism
- DNA and Nucleic Acid Chemistry
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Innovative Human-Technology Interaction
- Eosinophilic Disorders and Syndromes
- Stroke Rehabilitation and Recovery
- Cytomegalovirus and herpesvirus research
- Chromosomal and Genetic Variations
- Chronic Lymphocytic Leukemia Research
- Prenatal Screening and Diagnostics
- Interactive and Immersive Displays
National Taiwan University
2008-2024
This case study in UbiComp technology and design presents a Playful Toothbrush system for assisting parents teachers to motivate kindergarten children learn proper thorough brushing skills. The includes vision-based motion tracker that recognizes different tooth strokes game which the child cleans virtual, mirror picture of his/her dirty teeth by physically own teeth. user results suggest enhances effectiveness their teeth, as measured number strokes, duration thoroughness cleaning.
Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance. This study develops a compound, JMF4073, inhibiting thymidylate (TMP) and cytidylate (CMP) kinases, aiming for new therapy against TKI-resistant CML. In vitro in vivo treatment JMF4073 eliminates WT-Bcr-Abl-32D CML cells. However, T315I-Bcr-Abl-32D cells are less vulnerable JMF4073. Evidence is presented that ATF4-mediated upregulation GSH be...
Abstract This study used DNA methyltransferase 3b (DNMT3b) knockout cells and the functional loss of DNMT3b mutation in immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) to understand how dysfunction causes genome instability. We demonstrated that R-loops contribute damages ICF cells. More prominent damage signal was due expression acquirement p53 mutation. Genome-wide ChIP-sequencing mapped sites at satellite repetitive sequences including (peri-)centromere regions....
Measurement of four dNTP pools is important for investigating metabolism, genome stability, and drug action. In this report, we developed a two-step method quantitating dNTPs by the combination rolling circle amplification (RCA) quantitative polymerase chain reaction (qPCR). We used CircLigase to generate single-strand DNA in circular monomeric configuration, which was then first step RCA that contained three excess quantification one at limiting levels. The second products qPCR, primer...
ABSTRACT This study investigates how DNA methyltransferase 3b (DNMT3b) dysfunction causes genome instability. We showed that in DNMT3b deficient cells, R-loops contribute to prominent γH2AX signal, which was mapped repetitive satellite sequences including centromere regions. By ChIP and DRIP analyses, our data revealed centromeric cells are removed by XPG/XPF, thus generating breaks centromeres increase mitotic aberration. In immunodeficiency-centromeric instability-facial anomalies (ICF)...