A5078190723- melanin and skin pigmentation
- RNA regulation and disease
- Additive Manufacturing and 3D Printing Technologies
- Biochemical Analysis and Sensing Techniques
- Additive Manufacturing Materials and Processes
- Silk-based biomaterials and applications
- Animal Genetics and Reproduction
- High Temperature Alloys and Creep
- Pluripotent Stem Cells Research
- Hair Growth and Disorders
- Regulation of Appetite and Obesity
- Skin Protection and Aging
- Coastal and Marine Dynamics
- Welding Techniques and Residual Stresses
- Plant Reproductive Biology
- Genomics and Chromatin Dynamics
- Transgenic Plants and Applications
- Fatigue and fracture mechanics
- Metallurgy and Material Forming
- Geotechnical Engineering and Soil Mechanics
- Photochromic and Fluorescence Chemistry
- Microstructure and mechanical properties
- High-Velocity Impact and Material Behavior
- Skin and Cellular Biology Research
- Tissue Engineering and Regenerative Medicine
Villanova University
2024-2025
University of Florida
2025
University of Delaware
2025
ZHAW Zurich University of Applied Sciences
2020-2023
Fraunhofer Institute for Casting, Composite and Processing Technology IGCV
2018
Swiss Federal Laboratories for Materials Science and Technology
2012-2013
Rider University
1972-1982
Jackson Laboratory
1964-1977
Smith College
1972
Louisiana State University
1962
Selective laser melting (SLM) is gaining increasing relevance in industry. Residual deformations and internal stresses caused by the repeated layerwise of metal powder transient cooling solidified layers still presents a significant challenge to profitability quality process. Excessive distortions or cracking may lead expensive rejects. In practice, critical additively manufactured parts are either iteratively pre-compensated redesigned based on production experience. To satisfy need for...
Cost and resource efficiency of Laser Beam Melting (LBM) highly depend on powder recycling procedures. Non-solidified can be sieved reused in subsequent build cycles. However, due to quality concerns, is not commonly practiced. One effect, which impair the quality, lies formation insertion spatter particles during melting process. In this paper, emerging LBM AlSi10Mg are characterized regarding geometric (size, morphology), chemical (alloy composition, oxygen content, oxide layer thickness)...
In laser based powder-bed fusion of metals (PBF-LB/M), parts are fabricated by melting layers powder using a high-intensity beam. During this process, the material is exposed to rapid cooling rates and intense thermal gradients, which underlying causes residual stress formation development unique microstructure in these components. Therefore, understanding heat transfer phenomenon reliably representing temperature profiles simulation frameworks prerequisites for studying during PBF-LB/M...
ABSTRACT Alleles at the agouti locus in mouse determine synthesis of either phaeomelanin or eumelanin by follicular melanocytes altering hair follicle environment. The method dermal-epidermal recombination skin from C57BL/6J a/a and Aw-J/Aw-J embryos was used this study to establish precise site gene action within follicle. pigmentary pattern hairs formed grafts specific for genotype dermal (mesodermal) component epidermal (ectodermal) had no influence on type pattern. These results indicate...
In laser powder bed fusion (LPBF), complex components are manufactured layer-by-layer via scanning the cross-sections of a 3D CAD model using high intensity laser. Throughout this process, material is exposed to temperature profiles that significantly differ from conventional manufacturing methods, and result in development unique inhomogeneous microstructure levels residual stresses additively fabricated parts. The large gradients rapid cooling rates around moving spot, overall...
Abstract Mice homozygous for the gene steel ( S1 ) are black‐eyed white, anemic and sterile. Previous studies have shown that pigment defect in skin hair results from a failure of tissue environment to support cell development. In an attempt analyse more critically this block pigmentation by skin, recombinations were made between dermal mesoderm epidermal ectoderm normal mutant 13 day mouse embryos. The re‐combined pieces then grown 14 days chick coelom subsequently examined melanocytes...
Abstract The mechanism involved in the development of pigmentary pattern piebald ( s / ) mouse embryos was investigated through use a combination grafting method. Skin from potentially white spotted area ranging age 11 days to birth combined with 9‐day neural tubes. Following tissues chick host embryos, melanoblasts migrated nerual tube into developing skin, and appearance pigment hair follicles interfollicular epidermis grafted skin determined. Eleven‐day produced pigmented only 16% cases,...
ABSTRACT Depilated is a recessive mutation on Chromosome 4 in the position b-1.93±0.51- dep-3.45±0.68.-Pt. It causes severe abnormalities of hair structure. The site action dep was investigated by method dermal-epidermal recombination. Skins from 14-day mutant and normal mouse embryos were separated into dermal epidermal components, recombined, grown histocompatible testes for 20 days. recombinations made +/+ epidermis with dermis, dep/dep dermis dermis. Grafts that contained as one...
Additive manufacturing technologies such as fused filament fabrication (FFF) allow the production of metastructures with global properties that can be tailored to their specific application. This study simulated and optimized an auxetic re-entrant structure a stiffness gradient for enhanced energy absorption low acceleration peaks under different low-velocity impact conditions. The finite-element method (FEM) was used, appropriate constitutive models were fitted static dynamic tensile...
Abstract Pigment cell differentiation was studied in cultures derived from 14‐day embryonic mouse skin, and of dermal or epidermal skin cells. Cell dissociated whole produced melanocytes very small numbers, they were always present association with groups epithelial‐like dermis no during the three week culture period. Epidermal established mechanically aggregates cells first formed after 30 hours culture, large numbers two days. cells, contrast to other did not survive beyond 11 days,...