A5014182741- Land Use and Ecosystem Services
- Piperaceae Chemical and Biological Studies
- Environmental Changes in China
- Remote Sensing and Land Use
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Environmental and Agricultural Sciences
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Remote Sensing in Agriculture
- Soil erosion and sediment transport
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- Cryospheric studies and observations
- Soil Carbon and Nitrogen Dynamics
- Hydrology and Watershed Management Studies
- Immune cells in cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Sexual Differentiation and Disorders
- Plant Water Relations and Carbon Dynamics
Lanzhou University
2025
Hebei Agricultural University
2025
Northwest Institute of Mechanical and Electrical Engineering
2025
Northwest A&F University
2017-2025
Beijing Jishuitan Hospital
2025
Capital Medical University
2020-2025
Peking University
2025
Huazhong University of Science and Technology
2007-2024
China Agricultural University
2021-2024
University of Glasgow
2024
Neuroendocrine prostate cancer (NEPC) typically implies severe lethality and limited treatment options.The precise identification of NEPC cells holds paramount significance for both research clinical applications, yet valid biomarker remains to be defined.Methods: Leveraging 11 published NE-related gene sets, single-cell RNA-sequencing (scRNA-seq) cohorts, 15 bulk transcriptomic 13 experimental models (PCa), we employed multiple advanced algorithms construct validate a robust risk prediction...
Understanding how climatic factors, soil properties, and vegetation characteristics influence the inter-site inter-annual variations in Q10 of respiration across biomes may help understanding mechanisms carbon (C) cycle its feedback to global warming. We compiled in-situ measured temperature sensitivity (Q10) analyzed relationship with potential controls climate various at scale. Results indicate that 5 cm depth varies from 1.100 13.464 biomes, coefficient variation 47.4%. all measurement...
In Beijing, capital of China, decreasing visibility has become a serious problem on people's life, thus hot environmental concern. An urban roadside site in Beijing was chosen to collect 24-h TSP, PM10 and PM2.5 samples for one month each season from June 2009 March 2010. The PM mass concentrations, the concentrations ions, EC, OC metals were measured, their correlation with visibility, as well influence weather factors studied. results showed that daily mean 75–1350 µg/m3 (mean 275.8),...
Agricultural land abandonment and retirement are important lead to different types of use cover change. Generally, caused by social environmental factors result in ecological economic benefits costs. Faced with the complexity agricultural change over time, this study aims develop a new framework distinguish between detect extent exact year using Google Earth Engine (GEE). We tested our approach for three typical regions northern China crop-pasture band, where widespread. First, based on...
Abstract Stress in the endoplasmic reticulum (ER) may perturb proteostasis and activates unfolded protein response (UPR). UPR activation is frequently observed cancer cells believed to fuel progression. Here, we report that one of three sensors, ATF6α, was associated with prostate (PCa) development, while both genetic pharmacological inhibition ATF6α impaired survival castration‐resistance PCa (CRPC) cells. Transcriptomic analyses identified molecular pathways deregulated upon depletion,...
Accurate soil moisture retrieval of a large area in high resolution is significant for plateau pasture. The object this paper to investigate the estimation volumetric vegetated areas pasture using fully polarimetric C-band RADARSAT-2 SAR (Synthetic Aperture Radar) images. Based on water cloud model, Chen and Dubois we proposed two developed algorithms validated their performance experimental data. We eliminated effect vegetation cover by model minimized surface roughness solving equations....
Abstract Benzophenones are widely supplemented in personal care products, but little is known about its neurodevelopmental toxicity. The previous epidemiological study discovered a negative correlation between maternal exposure to benzophenone metabolite 4‐hydroxybenzophenone (4HBP) and child's neurodevelopment, yet the causal relationship detailed mechanism remain be defined. Here, it reported that prenatal, not postnatal, environmentally relevant level of 4HBP impairs hippocampus...
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies with complex phenotypic, etiological, biological, clinical heterogeneities. Previous studies have proposed different clinically relevant subtypes HNSCC, but little known about its corresponding prognosis or suitable treatment strategy. Here, we identified 101 core genes from three prognostic pathways, including mTORC1 signaling, unfold protein response, UV response UP, in 124 pairs tumor matched normal...
In order to protect the ecological environment and solve poverty problem in western region, China has established an migration (EM) policy. This policy aims relocate populations from poverty-stricken areas with fragile environments, which inevitably leads changes land cover environment. The objective of this study was identify effects EM a typical region (Wuwei), including risk (ER). A change monitoring method implemented for 2010–2019 period six classes using random forest, is effective...
Nitrogen (N) deposition in China remains high. However, the response of species-level plant elemental stoichiometry to N is not comprehensive. This study aimed investigate and phosphorus (P) stoichiometric understory herbaceous plants at species level. An addition experiment Larix principis-rupprechtii plantation was conducted with multiple-gradient (0, 5, 10, 20, 40, 80, 160 kg ha−1 yr−1). The P leaves roots nine representative determined. significantly increased concentration N/P ratio...
Large-scale agricultural and animal husbandry production in Shaanxi Province of China has led to significant environmental pollution, due the incineration vast amounts waste annually. As land area used for vegetable cultivation expands farming practices evolve, demand organic substrates continues grow. To optimize cost savings enhance efficiency, this study investigated effects different substrate compositions on cucumber (Cucumis sativus) yield quality, using ‘Jinyou 35’ as experimental...
Aims Glioma-associated oncogene homologue 1 ( GLI1 ) was recently shown to be coamplified with mouse double minute 2 MDM2 ), cyclin-dependent kinase 4 CDK4 and some other adjacent genes in a significant subset of -altered mesenchymal tumours well-differentiated/dedifferentiated liposarcomas, which are characterised by amplification. Given that is also amplified low-grade osteosarcoma (LGOS), we investigated the prevalence amplifications/fusions series 15 cases -amplified LGOS, an area has...
Abstract Background The failure of novel therapies effective in preclinical animal models largely reflects the fact that current do not really mimic pathological/therapeutic features glioblastoma (GBM), which most temozolomide chemoradiotherapy (RT/TMZ) regimen can only slightly extend survival. How to improve RT/TMZ efficacy remains a major challenge clinic. Methods Syngeneic G422 TN -GBM model mice were subject RT/TMZ, surgery, piperlongumine (PL), αPD1, glutathione. Metabolomics or...
The continuous ecological management of the Loess Plateau is known throughout world for two strategies: integrated soil conservation project that began in 1970s, and “Grain Green” 1990s. Six sub-catchments nested Beiluo River basin were selected to investigate streamflow regime variations during periods. annual trends change points detected using a bootstrap-based Mann-Kendall test Pettitt test. Annual (from 1950s 2011) exhibited significantly negative five out six catchments, varying from...