A5003600825- Renal Diseases and Glomerulopathies
- Polyomavirus and related diseases
- Cancer Immunotherapy and Biomarkers
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Renal cell carcinoma treatment
- Chronic Lymphocytic Leukemia Research
- Primary Care and Health Outcomes
- Biomedical Ethics and Regulation
- Patient Satisfaction in Healthcare
- Ion channel regulation and function
- Epilepsy research and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Nephrotoxicity and Medicinal Plants
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Streptococcal Infections and Treatments
- Telemedicine and Telehealth Implementation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Kidney Injury Research
- Biomedical Research and Pathophysiology
- Cardiac electrophysiology and arrhythmias
- Vasculitis and related conditions
- Potassium and Related Disorders
Mayo Clinic
2017-2025
Institute for Biomedical Engineering
2025
ETH Zurich
2022-2025
Mayo Clinic in Florida
2024
WinnMed
2017-2021
Hypertension Institute
2020
Sound Shore Medical Center
2013-2017
Albert Einstein College of Medicine
2017
New York Medical College
2013
Hospital for Sick Children
2006
Significance Statement Kidney toxicity from use of immune checkpoint inhibitors is being recognized as an increasingly frequent complication treatment. However, existing data on inhibitor–associated AKI have been limited to small, mostly single-center studies. In this multicenter study 138 patients with and 276 controls, the authors characterize clinical features identify risk factors associated its development, clinicopathologic features, determinants kidney recovery after episode. Failure...
Immune checkpoint inhibitors (ICIs) are effective in treating several cancers; however, acute kidney injury (AKI) can occur as part an immune-related adverse event (iRAE). Biomarkers at the time of AKI diagnosis may help determine whether they ICI- related and guide therapeutic strategies.
IntroductionKidney transplant (Ktx) recipients are excluded from clinical trials of immune checkpoint inhibitors. The aim this systematic review was to assess the safety inhibitors among Ktx patients.MethodsA literature search conducted using MEDLINE, EMBASE, and Cochrane Database inception through April 2019. We included studies that reported outcomes who received for cancer treatment. Outcomes interest were allograft rejection and/or failure.ResultsTwenty-seven articles with a total 44...
Background The objective of this case cohort study was to describe our experience in the care patients with immune checkpoint inhibitor–related acute interstitial nephritis (ICI-AIN) including rechallenge. Methods A descriptive series that received an ICI and had AKI (defined as a ≥1.5-fold increase serum creatinine) immune-related adverse event (irAE), biopsy-proven or clinically suspected ICI-AIN from January 1, 2014 December 2018 at Mayo Clinic, Rochester. We studied details regarding...
Background Telenephrology has become an important health care delivery modality during the COVID-19 pandemic. However, little is known about patient perspectives on quality of provided via telenephrology compared to face-to-face visits. We aimed use objective data study patients’ outpatient nephrology received (phone and video) versus Methods retrospectively studied adults who in Nephrology & Hypertension division at Mayo Clinic, Rochester, from March July 2020. used a standardized...
Immunotherapy has grown significantly in the management of hematological and solid organ tumors. In-depth knowledge T-cell pathways led to development adoptive cell transfer techniques subsequent evolution chimeric antigen receptor (CAR-T) therapies.1Gill S. Maus M.V. Porter D.L. Chimeric T therapy: 25 years making.Blood Rev. 2016; 30: 157-167Crossref PubMed Scopus (136) Google Scholar CAR-T cells are biologically engineered with a CAR that recognizes tumor antigen. receptors equipped...
Background: Chronic Kidney Disease (CKD) is a significant public health issue globally. Its progressive nature calls for innovative care models to mitigate disease progression and enhance patient outcomes. An interdisciplinary clinic model may offer comprehensive tailored the needs of CKD patients. The aim this study evaluate impact an on progression, healthcare utilization, social determinants (SDOH). Methods: We conducted retrospective cohort at Mayo Clinic in Rochester, Minnesota....
Brugada syndrome is increasingly recognized as a cause of sudden cardiac death. Many these patients do not get diagnosed due its dynamic and often hidden nature. We have come long way in understanding the disease process, electrophysiology appears to be intimately linked with sodium channel mutations or disorders. The rhythm can deteriorate into fatal ventricular arrhythmias. This makes it important for clinician aware conditions which arrhythmogenicity revealed even potentiated. present...
Crystalglobulinemia, a rare manifestation of monoclonal gammopathy, results from vascular deposition crystallized proteins leading to tissue injury. A 56-year-old man initially presented several years earlier with migratory polyarthralgias and blurry vision no unifying diagnosis. Following an acute episode malignant hypertension rapidly progressive kidney failure, biopsy was performed interpreted as idiopathic thrombotic microangiopathy. Further evaluation revealed underlying protein...
A 67-year-old woman with a history of metastatic melanoma on therapy presented to the oncology clinic worsening fatigue for 2 weeks. She had subjective fevers, chills, and pruritic rash. Her progressed pembrolizumab so she recently been started combination ipilimumab nivolumab about 3 months previously. Because concerns disease progression, underwent positron emission tomography–computed tomography (PET-CT) before being seen in clinic. PET-CT scan demonstrated an interval decrease...
Patients with cryoglobulinemic vasculitis (CV) can develop disease flare after rituximab administration. The objective of our study was to describe the prevalence, clinical characteristics, predisposing factors, and outcomes patients rituximab-associated CV.We conducted a retrospective in tertiary referral center until March 25, 2020.Among 64 CV who received therapy center, 14 (22%) developed flare. Median age 67.5 years. Seven (50%) had type II other half either I (n = 6) or III 1). Twelve...
<b><i>Introduction:</i></b> Sonographic technologies can estimate extravascular lung water (EVLW) in hemodialysis (HD) patients. This study investigated the suitability of a handheld scanner contrast to portable for quantifying EVLW hospitalized patients requiring HD. <b><i>Methods:</i></b> In this prospective study, 54 HD were enrolled. Bedside ultrasound was performed within 30 min before and after dialysis using (phased array transducer,...
Lupus nephritis is a life-threatening manifestation of systemic lupus erythematosus (SLE). This commonly suspected when patients present with elevated serum creatinine levels. But it important to be aware that even advanced disease in the kidney from SLE can have normal renal function, thus requiring high index suspicion. We case patient who presented nonspecific musculoskeletal symptoms and was diagnosed SLE. He also had nephrotic range proteinuria but his normal. A biopsy revealed diffuse...
Hyponatremia is an electrolyte imbalance encountered commonly in the hospital and ambulatory settings. It can be seen isolation or present as a complication of other medical conditions. therefore challenge to determine appropriate therapeutic intervention. An understanding etiology key instituting right treatment. Clinicians must not too hasty correct random laboratory value without first physiologic principle. We such case patient who presented with sodium 98 mmol/L, lowest recorded current...
Background: Peptide receptor radionuclide therapy with 177 Lu-dotatate is a novel for metastatic neuroendocrine cancers. It undergoes reabsorption at the proximal tubule; after breakdown of peptide fragment, Lu retained and continues its decay process exposing nephron to continuous low dose radiation. Pivotal NETTER-1 trial did not include patients eGFR <50 so effects in CKD known. Methods: We performed retrospective chart review all consecutive adult that received over 1 year Mayo...