A5102795014- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Blood disorders and treatments
- Autophagy in Disease and Therapy
- Pediatric health and respiratory diseases
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Calcium signaling and nucleotide metabolism
University Children's Hospital Zurich
2016-2020
University of Zurich
2018
// Patricia Jaaks 1 , Gianmarco Meier Nagjie Alijaj Eva Brack Peter Bode 2 Ewa Koscielniak 3 Marco Wachtel Beat W. Schäfer Michele Bernasconi Department of Oncology and Children's Research Center, University Hospital Zurich, Switzerland Surgical Pathology, Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Germany Correspondence to: Bernasconi, email: michele.bernasconi@kispi.uzh.ch Keywords: furin, proprotein convertases, rhabdomyosarcoma, apoptosis, IGF1R Received: February...
Background There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering TLDF known to increase number episodes neutropenia (FN). This study aimed investigate influence a lower versus standard on diagnostics and therapy. Methods In single pediatric cancer center using high (39°C tympanic-temperature) patients were observed prospectively (NCT01683370). The effect applying TLDFs (range 37.5°C 38.9°C) 39.0°C these measures was...
The Pediatric FN Definition 2012 Bern (NCT01683370) study recruited patients from August to May 2013 in a single Center, the Department of Pediatrics, Inselspital, University Hospital, Bern, Switzerland. 39 were observed during 289 months cumulative chemotherapy exposure time. 43 episodes fever chemotherapy-induced neutropenia (FN) diagnosed 20 39 patients. Information on is published here, based >8000 temperature measurements and >1800 CBCs, together with exact relative time data. Data...
Abstract Alveolar rhabdomyosarcoma (aRMS) is a highly malicious childhood malignancy characterized by specific chromosomal translocation encoding the oncogenic transcription factor PAX3-FOXO1. As aRMS cells are addicted to tumor-specific fusion protein, it may serve as an ideal therapeutic target. Previously, we have identified from large drug library screen compound Fenretinide (retinoic acid p-hydroxyanilide), which already in clinical use, affect both PAX3-FOXO1 expression well cell...