A5017815583- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Magnolia and Illicium research
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2023
Immunotherapy is a promising therapy for metastatic gastric cancer (GC) patients. However, the component of tumor microenvironment (TME) pivotal factor hindering immunotherapy outcome. CD8 T cells suppress progression. This study developed an immune subtyping system and prognostic model guiding personalized GC patients.Marker genes related to were identified by weighted correlation network analysis (WGCNA). Consensus clustering was used develop subtypes. Univariate Cox regression performed...
Introduction: Magnolol is beneficial against inflammation-mediated damage. However, the underlying mechanisms by which magnolol exerts anti-inflammatory effects on macrophages remain unclear. Objective: In this study, network pharmacology and experimental validation were used to assess effect of inflammation caused lipopolysaccharide (LPS) in RAW264.7 cells. Materials Methods: Genes related identified PubChem Swiss Target Prediction databases, gene information about macrophage polarization...