A5101657267- Amyloidosis: Diagnosis, Treatment, Outcomes
- Evolution and Paleontology Studies
- Chronic Myeloid Leukemia Treatments
- Animal Ecology and Behavior Studies
- Bat Biology and Ecology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Primate Behavior and Ecology
- Multiple Myeloma Research and Treatments
- Morphological variations and asymmetry
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
- Plant and animal studies
- Wildlife Ecology and Conservation
- Genetic diversity and population structure
- Cancer Treatment and Pharmacology
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Species Distribution and Climate Change
- Parathyroid Disorders and Treatments
- Neuroscience of respiration and sleep
- Inflammatory Myopathies and Dermatomyositis
- Protein Kinase Regulation and GTPase Signaling
- Potassium and Related Disorders
Linnaeus University
2025
Kalahari Meerkat Project
2018-2024
University of Pretoria
2020-2024
Rhodes University
2018
Boston University
2001-2014
Boston Medical Center
2001-2014
Florida Museum of Natural History
2013
University of Florida
2013
University Medical Center
2001-2010
Amyloidosis Foundation
2009
Background. Lenalidomide is an immunomodulatory agent used to treat plasma cell dyscrasias. We previously observed worsening of kidney function in a high proportion patients with AL amyloidosis during lenalidomide treatment. The objective this study characterize alterations among undergoing treatment lenalidomide. Methods. This secondary analysis ongoing clinical trial at single referral centre. Forty-one received or without dexamethasone monthly cycles. Kidney dysfunction was defined as ≥...
Differences in individual locomotor activity patterns may be linked to a number of ecological factors, such as changes ambient temperature or photoperiod. Observations on subterranean mammals suggest that they exhibit diel rhythms despite the lack visual cues their underground burrows, but it is unknown how seasonality and characteristics affect activity. In this study we use RFID technology monitor daily wild, social Natal mole-rats ( Cryptomys hottentotus natalensis ) during summer winter...
Many animals adapt their activity patterns to the best environmental conditions using daily rhythms. African mole-rats are among mammals that have become models for studying how these rhythms can be entrained by light or temperature in experimental laboratory studies. However, it is unclear whether they exhibit similar circadian natural lightless, subterranean environment. In this study, we used biologging investigate of wild, highveld mole-rats. We show cycle exhibited an ultradian rhythm...
In eusocial invertebrates and obligate cooperative breeders, successful reproduction is dependent on assistance from non-breeding group members. Although naked (
Abstract Cooperation and group living have been suggested to facilitate survival in varying environments under challenging conditions. However, may also be associated with costs, particularly species where individuals within groups compete for limited resources. The costs benefits of cooperative on cooperatively breeding mammals remain unclear. Here, we use data collected from wild, Natal mole‐rats ( Cryptomys hottentotus natalensis ) inhabiting a seasonally environment assess whether body...
Abstract: Increased cardiac wall thickness (WT) is a hallmark of amyloid cardiomyopathy. Sporadic reports have suggested that there may be regression WT after successful therapy pri...
Eusocial societies are characterized by a clear division of labour between non-breeding workers and breeding queens, queens often do not contribute to foraging, defence other maintenance tasks. It has been suggested that the structure organization social mole-rat groups resembles eusocial insect societies. However, rarely investigated in wild mole-rats, it is unknown whether breeders show decreased foraging activity compared with helpers natural groups. Here, we that, Damaraland mole-rats...
High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response prolonged overall survival systemic AL amyloidosis. In this retrospective study, we evaluated clinical responses 69 patients with predominant liver involvement who were treated high-dose intravenous from 1998 2006. Nine (13%) died treatment-related mortality, similar without hepatic involvement. The was 81% at one year 61% five years, by...
ABSTRACT Damaraland mole-rats ( Fukomys damarensis) are usually viewed as a eusocial or obligate cooperative breeder in which successful reproduction is dependent on help from closely related group members. However, because longitudinal studies of their natural environment uncommon, the extent to by breeders relies assistance other members unclear, and for non-breeders, immediate delayed fitness consequences staying helping poorly understood. Using data 7-year field study marked individuals,...
We studied the correlates of population density and body size, growth rates, litter group size in Damaraland mole-rats (Fukomys damarensis (Ogilby, 1838)) at two study sites with contrasting densities. Group probability recapture were independent site. However, differed between sites, suggesting that may affect life-history traits social mole-rats. At low-density site (0.13 groups/ha), individuals significantly larger subordinate males showed higher rates than high-density (0.41 which...
Abstract Groups of wild animals can vary considerably in their composition, including the proportion group members who are male or female, that is within‐group sex ratio. Variation ratios arise from active adjustment litter by mothers, differences mortality, dispersal and immigration, stochastic variation recruitment. ratio have consequences for competition affect individual life histories throughout development. In this paper, we explore which processes may generate Damaraland mole‐rats (...
Treatment with high-dose melphalan chemotherapy supported by hematopoietic rescue autologous stem cells produces high rates of hematologic responses and improvement in survival organ function for patients AL amyloidosis. Ongoing clinical trials explore pre-transplant induction regimens, post-transplant consolidation or maintenance approaches, compare transplant to non-transplant regimens. To put these studies into context, we reviewed our recent experience amyloidosis the Amyloid Research...
Abstract Selection pressures underpinning the evolution of mammalian sociality and body mass variation have spurred great interest for several decades. Because they inhabit a wide range geographic localities habitats, African mole-rat subspecies Cryptomys hottentotus present unique opportunity to further our understanding intra- interspecific in species. We compared demographics masses among 4 C. subspecies: Mahali mole-rat, h. mahali; highveld pretoriae; Natal natalensis; common within...
Dispersal from the natal site to breeding sites is a crucial phase in life history of animals and can have profound effects on reproductive ecology structure animal societies. However, few studies assessed dispersal dynamics subterranean mammals it unknown whether distances are constrained by living underground. Here we show, social, Damaraland mole-rats ( Fukomys damarensis ), that lifestyle does not preclude long distance both sexes capable successfully dispersing (>4 km). Body...
The social mole-rats of the family Bathyergidae show elaborate organisation that may include division labour between breeders and non-breeders as well across within their groups. However, comparative behavioural data taxa are rare contrasts similarities species poorly understood. Field studies bathyergids usually involve capturing all group members until entire is captured. Because each animal only captured once traps typically placed in close proximity to active foraging areas, order which...