A5014784808- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- Polysaccharides Composition and Applications
- Wound Healing and Treatments
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Electrospun Nanofibers in Biomedical Applications
- Protein purification and stability
- Computational Drug Discovery Methods
- Graphene and Nanomaterials Applications
- Herpesvirus Infections and Treatments
- Nanoparticles: synthesis and applications
- Cancer Treatment and Pharmacology
- Advanced Polymer Synthesis and Characterization
- Food composition and properties
- Nanoplatforms for cancer theranostics
- Oral microbiology and periodontitis research
- Lipid Membrane Structure and Behavior
University of Sargodha
2015-2025
Islamia University of Bahawalpur
2014-2018
Loughborough University
2016
University of Benin
2015-2016
University of Lahore
2014
The present work was conducted to prepare and evaluate transdermal patches with optimization of suitable polymeric blend poly(meth) acrylates (Eudragit®) (Ammonio Methacrylate Copolymer Ph Eur) for sustained delivery glimepiride.Polymeric matrix films were prepared by using Ammonio Eur RL 100 RS as the film former, dibutyl phthalate (30% w/w) plasticizer. Patches characterized physical appearance, thickness, weight variation, folding endurance, percentage erosion, swelling index, moisture...
In the current study, a pH sensitive intelligent hydroxypropyl-β-cyclodextrin-based polymeric network (HP-β-CD-g-MAA) was developed through solution polymerization technique for site specific delivery of cytarabine in colonic region. Prepared hydrogel formulations were characterized loading (%), ingredient's compatibility, structural evaluation, thermal integrity, swelling pattern, release behavior and toxicological profiling rabbits. Moreover, pharmacokinetic profile also determined New...
The purpose of the current research is to formulate a smart drug delivery system for solubility enhancement and sustained release hydrophobic drugs. Drug solubility-related challenges constitute significant concern formulation scientists. To address this issue, recent study focused on developing PEG-g-poly(MAA) copolymeric nanogels enhance olmesartan, poorly soluble drug. researchers employed free radical polymerization technique these nanogels. Nine formulations were formulated. newly...
Objectives: The study aimed to develop safe, effective, and targeted drug delivery system for administration of nonsteroidal anti-inflammatory drugs (NSAIDs) in the form microgels. We developed pH responsive microgels overcome mucosal damage caused by traditional immediate release dosage forms. Colon targeting controlled formulations have potential improve efficacy reduce undesirable effects associated with NSAIDs.Methods: sensitive oral hydrogel demonstrates target colon. Cellulose acetate...
Microneedle patches (MNPs) are one of the emerging approaches for drug delivery involving minimal invasion and improved skin penetration macro- micro-entities. Herein, we report dissolvable microneedle (dMNPs) as a novel tool better systemic Simvastatin in management hypocholesteremia. Thiolated chitosan (TC), polyvinyl pyrolidone (PVP) alcohol (PVA) were employed development dMNPs. Developed characterized through SEM, FTIR, DSC, TGA, PXRD, dissolution testing, tensile strength, elongation...
Tofacitinib is an antirheumatic drug characterized by a short half-life and poor permeability, which necessitates the development of sustained release formulation with enhanced permeability potential. To achieve this goal, free radical polymerization technique was employed to develop mucin/chitosan copolymer methacrylic acid (MU-CHI-Co-Poly (MAA))-based hydrogel microparticles. The developed microparticles were for EDX, FTIR, DSC, TGA, X-ray diffraction, SEM, loading; equilibrium swelling...
Abstract: The aim of this study was to enhance the solubility rosuvastatin (RST) calcium by developing β-cyclodextrin-g-poly(2-acrylamido-2-methylpropane sulfonic acid [AMPS]) hydrogel microparticles through aqueous free-radical polymerization technique. Prepared were characterized for percent entrapment efficiency, studies, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermal gravimetric analysis, powder X-ray diffraction, electron microscopy, zeta size and...
In the present study, pH-sensitive, biodegradable, and biocompatible Na-CMC/pectin poly(methacrylic acid) hydrogels were synthesized using an aqueous free radical polymerization technique encapsulated by cytarabine (anti-cancer drug). The aim of project was to sustain plasma profile through oral administration. Sodium carboxymethyl cellulose (Na-CMC) pectin cross-linked chemically with methacrylic acid (MAA) as a monomer, methylene bisacrylamide (MBA) cross-linker ammonium per sulfate (APS)...
This study aimed to create a controlled delivery system for Tapentadol Hydrochloride by developing interpenetrating networks (IPNs) of Natrosol-Pectin copolymerized with Acrylic Acid and Methylene bisacrylamide, analyze the effects various ingredients on physical chemical characteristics IPNs.Novel Hydrochloride-loaded based IPNs were formulated using free radical polymerization technique. Co-polymerization (AA) Natrosol Pectin was performed bisacrylamide (MBA). Ammonium persulfate (APS)...
Abstract In this work, successful efforts have been performed for solubility enhancement of acyclovir. pH‐sensitive β‐Cyclodextrin‐g‐poly methacrylic acid (MAA) hydrogel microparticles were developed. β‐Cyclodextrin, MAA, N , ‐methylene bisacrylamide used as polymer, monomer, and cross‐linker, respectively. Nine different formulations (BM‐1 to BM‐9) prepared by aqueous free radical polymerization. Developed characterized FTIR, Differential Scanning Calorimetry/Thermo Gravimetric Analysis,...
In current research study, novel chitosan-based hydrogel was formulated via crosslinking graft copolymerization of acrylic acid (AA) and chitosan. Potassium persulfate used as free radical generator in the presence crosslinker (methylene bis acrylamide (MBA)). FTIR spectroscopy employed to elucidate structure hydrogel. Moreover, sample morphology examined by scanning electron microscopy (SEM) thermal analysis conducted using thermogravimetric (DSC/TGA). The influence reaction variables such...