A5042363675- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Boron Compounds in Chemistry
- Nanocluster Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Breast Cancer Therapies
Chongqing University of Arts and Sciences
2022-2023
Chongqing University
2022-2023
Palbociclib is the world's first CDK4/6 kinase inhibitor to be marketed. However, it not effective in treatment of triple negative breast cancer (TNBC) due loss retinoblastoma protein expression. Thus, combinatorial chemotherapy indispensable for TNBC treatment. Herein, a carrier-free nanomedicine self-assembled from palbociclib dimers and Ce6 enhanced combined chemo-photodynamic therapy reported. The dimeric prodrug (Palb-TK-Palb) was synthesized by conjugating two molecules connecting...
Photodynamic therapy (PDT) is an effective noninvasive therapeutic strategy that has been widely used for anti-tumor by the generation of excessive highly cytotoxic ROS. However, poor water solubility photosensitizer, reactive oxygen species (ROS) depleting high concentrations glutathione (GSH) in tumor microenvironment and activation DNA repair pathways to combat oxidative damage, will significantly limit effect PDT. Herein, we developed a photosensitizer prodrug (CSP) conjugating...
Mitochondrial dysfunction is a feature of cancer cells and targeting mitochondria has emerged as promising anticancer therapy.